FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1926565542> ?p ?o ?g. }

• W1926565542 endingPage "2726" @default.
• W1926565542 startingPage "2712" @default.
• W1926565542 abstract "Rosmarinic acid (RA) is an importantly and naturally occurring polyphenol from plants of the mint family with potent biological activities. Here, the in vitro interaction of RA with bovine serum albumin (BSA) has been investigated using various biophysical approaches as well as molecular modeling methods, to ascertain its binding mechanism and conformational changes. The fluorescence results demonstrated that the fluorescence quenching of BSA by RA was mainly the result of the formation of a ground state BSA-RA complex, and BSA had one high affinity RA binding site with a binding constant of 4.18 × 10(4) mol L(-1) at 298 K. Analysis of thermodynamic parameters revealed that hydrophobic and hydrogen bond interactions were the dominant intermolecular force in the complex formation. The primary binding site of RA in BSA (site I) had been identified by site marker competitive experiments. The distance between RA and the tryptophan residue of BSA was evaluated at 3.12 nm based on Förster's theory of non-radiation energy transfer. The UV-vis absorption, synchronous fluorescence, three-dimensional fluorescence, 8-anilino-1-naphthalenesulfonic acid (ANS) fluorescence, circular dichroism (CD), and Fourier transform infrared (FT-IR) spectra confirmed that the conformation and structure of BSA were altered in the presence of RA. Moreover, the nuclear magnetic spectroscopy showed that the aromatic groups of RA took part in the binding reaction during the BSA-RA complexation. In addition, the molecular picture of the interaction mechanism between BSA and RA at the atomic level was well examined by molecular docking and dynamics studies. In brief, RA can bind to BSA with noncovalent bonds in a relatively stable way, and these findings will be beneficial to the functional food research of RA." @default.
• W1926565542 created "2016-06-24" @default.
• W1926565542 creator A5010503614 @default.
• W1926565542 creator A5020747315 @default.
• W1926565542 creator A5050124317 @default.
• W1926565542 creator A5062821023 @default.
• W1926565542 creator A5071933793 @default.
• W1926565542 creator A5090665216 @default.
• W1926565542 date "2015-01-01" @default.
• W1926565542 modified "2023-09-28" @default.
• W1926565542 title "Deciphering the binding patterns and conformation changes upon the bovine serum albumin–rosmarinic acid complex" @default.
• W1926565542 cites W1964210347 @default.
• W1926565542 cites W1966970536 @default.
• W1926565542 cites W1968813090 @default.
• W1926565542 cites W1971504361 @default.
• W1926565542 cites W1976020537 @default.
• W1926565542 cites W1976499671 @default.
• W1926565542 cites W1978044303 @default.
• W1926565542 cites W1979113373 @default.
• W1926565542 cites W1983476486 @default.
• W1926565542 cites W1983649348 @default.
• W1926565542 cites W1986247421 @default.
• W1926565542 cites W1992956731 @default.
• W1926565542 cites W1995913752 @default.
• W1926565542 cites W2000587059 @default.
• W1926565542 cites W2001907362 @default.
• W1926565542 cites W2002469023 @default.
• W1926565542 cites W2006514821 @default.
• W1926565542 cites W2007530541 @default.
• W1926565542 cites W200778230 @default.
• W1926565542 cites W2008316253 @default.
• W1926565542 cites W2016584314 @default.
• W1926565542 cites W2016625300 @default.
• W1926565542 cites W2018607875 @default.
• W1926565542 cites W2022520522 @default.
• W1926565542 cites W2040159478 @default.
• W1926565542 cites W2040856167 @default.
• W1926565542 cites W2042634918 @default.
• W1926565542 cites W2046217963 @default.
• W1926565542 cites W2047435888 @default.
• W1926565542 cites W2051274703 @default.
• W1926565542 cites W2052230935 @default.
• W1926565542 cites W2058808313 @default.
• W1926565542 cites W2061803160 @default.
• W1926565542 cites W2062228103 @default.
• W1926565542 cites W2062502251 @default.
• W1926565542 cites W2063326110 @default.
• W1926565542 cites W2066132900 @default.
• W1926565542 cites W2067174909 @default.
• W1926565542 cites W2072039459 @default.
• W1926565542 cites W2072851636 @default.
• W1926565542 cites W2072894291 @default.
• W1926565542 cites W2075705506 @default.
• W1926565542 cites W2080476005 @default.
• W1926565542 cites W2082028520 @default.
• W1926565542 cites W2085229333 @default.
• W1926565542 cites W2091995841 @default.
• W1926565542 cites W2093137972 @default.
• W1926565542 cites W2147068145 @default.
• W1926565542 cites W2156053468 @default.
• W1926565542 cites W2160739094 @default.
• W1926565542 cites W2163388941 @default.
• W1926565542 cites W2315359473 @default.
• W1926565542 cites W2319621644 @default.
• W1926565542 cites W2321837695 @default.
• W1926565542 cites W2322394345 @default.
• W1926565542 cites W2323947683 @default.
• W1926565542 cites W2328504859 @default.
• W1926565542 cites W2491458126 @default.
• W1926565542 doi "https://doi.org/10.1039/c5fo00597c" @default.
• W1926565542 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26146359" @default.
• W1926565542 hasPublicationYear "2015" @default.
• W1926565542 type Work @default.
• W1926565542 sameAs 1926565542 @default.
• W1926565542 citedByCount "53" @default.
• W1926565542 countsByYear W19265655422016 @default.
• W1926565542 countsByYear W19265655422017 @default.
• W1926565542 countsByYear W19265655422018 @default.
• W1926565542 countsByYear W19265655422019 @default.
• W1926565542 countsByYear W19265655422020 @default.
• W1926565542 countsByYear W19265655422021 @default.
• W1926565542 countsByYear W19265655422022 @default.
• W1926565542 countsByYear W19265655422023 @default.
• W1926565542 crossrefType "journal-article" @default.
• W1926565542 hasAuthorship W1926565542A5010503614 @default.
• W1926565542 hasAuthorship W1926565542A5020747315 @default.
• W1926565542 hasAuthorship W1926565542A5050124317 @default.
• W1926565542 hasAuthorship W1926565542A5062821023 @default.
• W1926565542 hasAuthorship W1926565542A5071933793 @default.
• W1926565542 hasAuthorship W1926565542A5090665216 @default.
• W1926565542 hasConcept C107824862 @default.
• W1926565542 hasConcept C112887158 @default.
• W1926565542 hasConcept C121332964 @default.
• W1926565542 hasConcept C121745418 @default.
• W1926565542 hasConcept C133571119 @default.
• W1926565542 hasConcept C178790620 @default.
• W1926565542 hasConcept C185592680 @default.
• W1926565542 hasConcept C2776706248 @default.

• next