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• W192686486 abstract "Summary of kinetic isotope effects on reactions of PRibPP FIG. 5. The observed combined, x, and primary, +, kinetic isotope effects for spontaneous hydrolysis of PRibPP at different percentages of completion of reaction for the tritiated component. The computer tit of the observed pri- mary effects to Equation 1 is drawn at the bottom and gave k,2C/k,4C equal to 1.02 2 0.027. The computer tit of the observed combined effects to Equation 2 is drawn at the top and gave k iH, ,+/k3,,, ,+ equal to 1.39 ? 0.026. Reaction Percentage of completion of re- action Type effectd Observed isotope 0% reaction isotope Estimated deute- effect rium PRibPP % Rib-5-P % PRibPP ATP-PRTU PRibATP PRibATP ATEPRT” PRibPP 20 10 PRibPP HGPRTh IMP 27 5 PRibPP 5 OMP 24 24 a Adenosine triphosphate phosphoribosyltransferase. * Hypoxanthine (guanine) phosphoribosyltransferase. c Orotate phosphoribosyltransferase. ” C, combined effect; l”, primary effect; 2”, secondary effect, of reaction for the reverse direction ATP phosphoribosyltrans- ferase reaction, that is, for the conversion of doubly labeled PRibATP to PRibPP. No effects were observed (Table II). In the hypoxanthine (guanine) phosphoribosyltransferase reaction, a primary ‘Y! kinetic isotope effect of 1.05 and a combined effect of 1.24 corresponding to an (Y secondary “H effect of 1.30 were obtained (Table II). In the orotate phospho- ribosyltransferase reaction, a primary “C! effect of 1.03 and a combined effect of 1.14 corresponding to an 01 secondary “H effect of 1.17 were obtained (Table II). Thus, all three enzy- matic reactions studied here as well as the spontaneous hydrolysis of PRibPP exhibit significant cy secondary :‘H ki- netic isotope effects. 1.27 1.08 C 1.39 1” 1.02 2” 1.41 C 1.10 1” 1.01 2” 1.11 C 0.99 0.99 1” 1.00 1.00 2” 0.99 C 1.20 1.24 1” 1.05 1.05 2” 1.30 1.20 C 1.12 1.14 1” 1.03 1.03 2” 1.17 1.12 1.00" @default.
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• W192686486 date "1978-05-01" @default.
• W192686486 modified "2023-09-30" @default.
• W192686486 title "Primary 14C and alpha secondary 3H substrate kinetic isotope effects for some phosphoribosyltransferases." @default.
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• W192686486 doi "https://doi.org/10.1016/s0021-9258(17)40789-7" @default.
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