Matches in SemOpenAlex for { <https://semopenalex.org/work/W1926970522> ?p ?o ?g. }
- W1926970522 abstract "Several biological properties of icariin have been identified, including its anticancer effect. However, the potential mechanisms underlying the effect of icariin on HepG2 hepatocellular carcinoma cells remain to be elucidated. The aim of the present study was to examine the effects of icariin on the proliferation and cytoskeleton of HepG2 cells. A 3‑(4,5‑dimethylthiazol‑2‑yl)‑2,5 diphenyltetrazolium bromide assay was used to assess the antiproliferative effects of icariin and to determine the optimal concentration and treatment schedule of icariin on the HepG2 cells. Cell cycle analysis was performed using fluorescence activated cell sorting, the protein expression of B‑cell lymphoma (Bcl)‑2 was determined using immunohistochemical and western blot analyses, and F‑actin in the cells was examined using confocal microscopy. The chemotherapeutic drug, oxaliplatin, was used as a positive control. The results demonstrated that the optimal concentration of icarrin to produce an antiproliferative effect on HepG2 cells was 10‑5 mol/l, and the optimal treatment duration was 72 h. The icariin group had a significantly higher proportion of cells in the G0/G1 phase, compared with the control group, treated with high glucose Dulbecco's modified Eagles medium with 10% fetal bovine serum (P<0.05). The proportion of HepG2 cells in the S phase was significantly lower in the oxaliplatin (24.19%; P<0.05) and icariin (21.07%; P<0.01) groups, compared with the control group (28.62%). Icariin markedly decreased the expression of Bcl‑2, compared with the control (P<0.01), and disrupted the polymerization of F‑actin filaments in the HepG2 cells. Therefore, the present study demonstrated that, at an optimum concentration of 10‑5 mol/l, icariin inhibited the proliferation of the HepG2 cells, promoted apoptosis by decreasing the expression of Bcl‑2, and disrupted the actin cytoskeleton." @default.
- W1926970522 created "2016-06-24" @default.
- W1926970522 creator A5037102607 @default.
- W1926970522 creator A5071531520 @default.
- W1926970522 creator A5085512975 @default.
- W1926970522 date "2015-09-02" @default.
- W1926970522 modified "2023-10-01" @default.
- W1926970522 title "Anti-proliferative and cytoskeleton-disruptive effects of icariin on HepG2 cells" @default.
- W1926970522 cites W1920739798 @default.
- W1926970522 cites W1964617786 @default.
- W1926970522 cites W1966236040 @default.
- W1926970522 cites W1985611492 @default.
- W1926970522 cites W1999934090 @default.
- W1926970522 cites W2001866617 @default.
- W1926970522 cites W2046728558 @default.
- W1926970522 cites W2056337361 @default.
- W1926970522 cites W2057848263 @default.
- W1926970522 cites W2061355624 @default.
- W1926970522 cites W2064896666 @default.
- W1926970522 cites W2077626314 @default.
- W1926970522 cites W2083956139 @default.
- W1926970522 cites W2096791952 @default.
- W1926970522 cites W2101167502 @default.
- W1926970522 cites W2108529628 @default.
- W1926970522 cites W2108823244 @default.
- W1926970522 cites W2117608682 @default.
- W1926970522 cites W2118583594 @default.
- W1926970522 cites W2126326024 @default.
- W1926970522 cites W2130866079 @default.
- W1926970522 cites W2142518692 @default.
- W1926970522 cites W2143655753 @default.
- W1926970522 cites W2144307786 @default.
- W1926970522 cites W2156417469 @default.
- W1926970522 cites W2166160125 @default.
- W1926970522 cites W2401518457 @default.
- W1926970522 cites W2469202630 @default.
- W1926970522 cites W1559638630 @default.
- W1926970522 doi "https://doi.org/10.3892/mmr.2015.4282" @default.
- W1926970522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26329131" @default.
- W1926970522 hasPublicationYear "2015" @default.
- W1926970522 type Work @default.
- W1926970522 sameAs 1926970522 @default.
- W1926970522 citedByCount "9" @default.
- W1926970522 countsByYear W19269705222016 @default.
- W1926970522 countsByYear W19269705222017 @default.
- W1926970522 countsByYear W19269705222019 @default.
- W1926970522 countsByYear W19269705222020 @default.
- W1926970522 countsByYear W19269705222021 @default.
- W1926970522 crossrefType "journal-article" @default.
- W1926970522 hasAuthorship W1926970522A5037102607 @default.
- W1926970522 hasAuthorship W1926970522A5071531520 @default.
- W1926970522 hasAuthorship W1926970522A5085512975 @default.
- W1926970522 hasBestOaLocation W19269705221 @default.
- W1926970522 hasConcept C142724271 @default.
- W1926970522 hasConcept C1491633281 @default.
- W1926970522 hasConcept C153911025 @default.
- W1926970522 hasConcept C16685009 @default.
- W1926970522 hasConcept C185592680 @default.
- W1926970522 hasConcept C190283241 @default.
- W1926970522 hasConcept C204787440 @default.
- W1926970522 hasConcept C2779404806 @default.
- W1926970522 hasConcept C2780685212 @default.
- W1926970522 hasConcept C2781018059 @default.
- W1926970522 hasConcept C29537977 @default.
- W1926970522 hasConcept C55493867 @default.
- W1926970522 hasConcept C62112901 @default.
- W1926970522 hasConcept C71924100 @default.
- W1926970522 hasConcept C86803240 @default.
- W1926970522 hasConceptScore W1926970522C142724271 @default.
- W1926970522 hasConceptScore W1926970522C1491633281 @default.
- W1926970522 hasConceptScore W1926970522C153911025 @default.
- W1926970522 hasConceptScore W1926970522C16685009 @default.
- W1926970522 hasConceptScore W1926970522C185592680 @default.
- W1926970522 hasConceptScore W1926970522C190283241 @default.
- W1926970522 hasConceptScore W1926970522C204787440 @default.
- W1926970522 hasConceptScore W1926970522C2779404806 @default.
- W1926970522 hasConceptScore W1926970522C2780685212 @default.
- W1926970522 hasConceptScore W1926970522C2781018059 @default.
- W1926970522 hasConceptScore W1926970522C29537977 @default.
- W1926970522 hasConceptScore W1926970522C55493867 @default.
- W1926970522 hasConceptScore W1926970522C62112901 @default.
- W1926970522 hasConceptScore W1926970522C71924100 @default.
- W1926970522 hasConceptScore W1926970522C86803240 @default.
- W1926970522 hasLocation W19269705221 @default.
- W1926970522 hasLocation W19269705222 @default.
- W1926970522 hasOpenAccess W1926970522 @default.
- W1926970522 hasPrimaryLocation W19269705221 @default.
- W1926970522 hasRelatedWork W1910661068 @default.
- W1926970522 hasRelatedWork W2008982965 @default.
- W1926970522 hasRelatedWork W2029410870 @default.
- W1926970522 hasRelatedWork W2040094445 @default.
- W1926970522 hasRelatedWork W2069088530 @default.
- W1926970522 hasRelatedWork W2098293771 @default.
- W1926970522 hasRelatedWork W2144061526 @default.
- W1926970522 hasRelatedWork W2347152249 @default.
- W1926970522 hasRelatedWork W2381980512 @default.
- W1926970522 hasRelatedWork W2408049765 @default.
- W1926970522 hasRelatedWork W2572294190 @default.
- W1926970522 hasRelatedWork W2594265096 @default.
- W1926970522 hasRelatedWork W2725807938 @default.