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• W1927019405 endingPage "615" @default.
• W1927019405 startingPage "605" @default.
• W1927019405 abstract "Rho-kinase (ROCK) is a serine/threonine kinase and one of the major downstream effectors of the small GTPase Rho. The Rho-ROCK pathway is involved in many aspects of neuronal functions including neurite outgrowth and retraction. The Rho-ROCK pathway becomes an attractive target for the development of drugs for treating central nervous system (CNS) disorders, since it has been recently revealed that this pathway is closely related to the pathogenesis of several CNS disorders such as spinal cord injuries, stroke, and Alzheimer's disease (AD). In the adult CNS, injured axons regenerate poorly due to the presence of myelin-associated axonal growth inhibitors such as myelin-associated glycoprotein (MAG), Nogo, oligodendrocyte-myelin glycoprotein (OMgp), and the recently identified repulsive guidance molecule (RGM). The effects of these inhibitors are reversed by blockade of the Rho-ROCK pathway in vitro, and the inhibition of this pathway promotes axonal regeneration and functional recovery in the injured CNS in vivo. In addition, the therapeutic effects of the Rho-ROCK inhibitors have been demonstrated in animal models of stroke. In this review, we summarize the involvement of the Rho-ROCK pathway in CNS disorders such as spinal cord injuries, stroke, and AD and also discuss the potential of Rho-ROCK inhibitors in the treatment of human CNS disorders." @default.
• W1927019405 created "2016-06-24" @default.
• W1927019405 creator A5012091198 @default.
• W1927019405 creator A5061418738 @default.
• W1927019405 creator A5070038776 @default.
• W1927019405 creator A5076608744 @default.
• W1927019405 date "2008-06-01" @default.
• W1927019405 modified "2023-10-12" @default.
• W1927019405 title "The therapeutic effects of Rho-ROCK inhibitors on CNS disorders" @default.
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