Matches in SemOpenAlex for { <https://semopenalex.org/work/W1927111502> ?p ?o ?g. }
- W1927111502 endingPage "372" @default.
- W1927111502 startingPage "365" @default.
- W1927111502 abstract "To compare the gene expression profile of osseointegration associated with a moderately rough and a chemically modified hydrophilic moderately rough surface in a human model.Eighteen solid screw-type cylindrical titanium implants, 4 mm long and 2.8 mm wide, with either a moderately rough (SLA) or a chemically modified moderately rough (SLActive) surface were surgically inserted in the retromolar area of nine human volunteers. The devices were removed using a trephine following 4, 7 and 14 days of healing. The tissue surrounding the implant was harvested, total RNA was extracted and microarray analysis was carried out to identify the differences in the transcriptome between the SLA and SLActive surfaces at days 4, 7 and 14.There were no functionally relevant gene ontology categories that were over-represented in the list of genes that were differentially expressed at day 4. However, by day 7, osteogenesis- and angiogenesis-associated gene expression were up-regulated on the SLActive surface. Osteogenesis and angiogenesis appeared to be regulated by BMP and VEGF signalling, respectively. By day 14, VEGF signalling remains up-regulated on the SLActive surface, while BMP signalling was up-regulated on the SLA surface in what appeared to be a delayed compensatory response. Furthermore, neurogenesis was a prominent biological process within the list of differentially expressed genes, and it was influenced by both surfaces.Compared with SLA, SLActive exerts a pro-osteogenic and pro-angiogenic influence on gene expression at day 7 following implant insertion, which may be responsible for the superior osseointegrative properties of this surface." @default.
- W1927111502 created "2016-06-24" @default.
- W1927111502 creator A5014866696 @default.
- W1927111502 creator A5016751033 @default.
- W1927111502 creator A5023900545 @default.
- W1927111502 creator A5027843631 @default.
- W1927111502 creator A5059742427 @default.
- W1927111502 creator A5073952077 @default.
- W1927111502 creator A5078853919 @default.
- W1927111502 date "2011-03-09" @default.
- W1927111502 modified "2023-10-01" @default.
- W1927111502 title "Gene expression profile of osseointegration of a hydrophilic compared with a hydrophobic microrough implant surface" @default.
- W1927111502 cites W1498671062 @default.
- W1927111502 cites W1849295147 @default.
- W1927111502 cites W1911090860 @default.
- W1927111502 cites W1972494459 @default.
- W1927111502 cites W1981520303 @default.
- W1927111502 cites W1981543646 @default.
- W1927111502 cites W1987654508 @default.
- W1927111502 cites W1989903786 @default.
- W1927111502 cites W1990985899 @default.
- W1927111502 cites W2004219681 @default.
- W1927111502 cites W2019987072 @default.
- W1927111502 cites W2020655054 @default.
- W1927111502 cites W2021077084 @default.
- W1927111502 cites W2033381020 @default.
- W1927111502 cites W2033395832 @default.
- W1927111502 cites W2045916315 @default.
- W1927111502 cites W2051767144 @default.
- W1927111502 cites W2051771323 @default.
- W1927111502 cites W2064167215 @default.
- W1927111502 cites W2084538058 @default.
- W1927111502 cites W2091344515 @default.
- W1927111502 cites W2095032932 @default.
- W1927111502 cites W2103711878 @default.
- W1927111502 cites W2105650532 @default.
- W1927111502 cites W2108944618 @default.
- W1927111502 cites W2109356886 @default.
- W1927111502 cites W2117492368 @default.
- W1927111502 cites W2117841258 @default.
- W1927111502 cites W2121265838 @default.
- W1927111502 cites W2122917194 @default.
- W1927111502 cites W2123212073 @default.
- W1927111502 cites W2129095015 @default.
- W1927111502 cites W2132246474 @default.
- W1927111502 cites W2138240434 @default.
- W1927111502 cites W2138617880 @default.
- W1927111502 cites W2149085971 @default.
- W1927111502 cites W2149767015 @default.
- W1927111502 cites W2158217645 @default.
- W1927111502 cites W2170687885 @default.
- W1927111502 doi "https://doi.org/10.1111/j.1600-0501.2010.02113.x" @default.
- W1927111502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21561478" @default.
- W1927111502 hasPublicationYear "2011" @default.
- W1927111502 type Work @default.
- W1927111502 sameAs 1927111502 @default.
- W1927111502 citedByCount "139" @default.
- W1927111502 countsByYear W19271115022012 @default.
- W1927111502 countsByYear W19271115022013 @default.
- W1927111502 countsByYear W19271115022014 @default.
- W1927111502 countsByYear W19271115022015 @default.
- W1927111502 countsByYear W19271115022016 @default.
- W1927111502 countsByYear W19271115022017 @default.
- W1927111502 countsByYear W19271115022018 @default.
- W1927111502 countsByYear W19271115022019 @default.
- W1927111502 countsByYear W19271115022020 @default.
- W1927111502 countsByYear W19271115022021 @default.
- W1927111502 countsByYear W19271115022022 @default.
- W1927111502 countsByYear W19271115022023 @default.
- W1927111502 crossrefType "journal-article" @default.
- W1927111502 hasAuthorship W1927111502A5014866696 @default.
- W1927111502 hasAuthorship W1927111502A5016751033 @default.
- W1927111502 hasAuthorship W1927111502A5023900545 @default.
- W1927111502 hasAuthorship W1927111502A5027843631 @default.
- W1927111502 hasAuthorship W1927111502A5059742427 @default.
- W1927111502 hasAuthorship W1927111502A5073952077 @default.
- W1927111502 hasAuthorship W1927111502A5078853919 @default.
- W1927111502 hasConcept C101414908 @default.
- W1927111502 hasConcept C104317684 @default.
- W1927111502 hasConcept C126322002 @default.
- W1927111502 hasConcept C136229726 @default.
- W1927111502 hasConcept C141071460 @default.
- W1927111502 hasConcept C150194340 @default.
- W1927111502 hasConcept C162317418 @default.
- W1927111502 hasConcept C185592680 @default.
- W1927111502 hasConcept C186836561 @default.
- W1927111502 hasConcept C192562407 @default.
- W1927111502 hasConcept C199343813 @default.
- W1927111502 hasConcept C2780394083 @default.
- W1927111502 hasConcept C2781411149 @default.
- W1927111502 hasConcept C55493867 @default.
- W1927111502 hasConcept C71924100 @default.
- W1927111502 hasConcept C8415881 @default.
- W1927111502 hasConceptScore W1927111502C101414908 @default.
- W1927111502 hasConceptScore W1927111502C104317684 @default.
- W1927111502 hasConceptScore W1927111502C126322002 @default.
- W1927111502 hasConceptScore W1927111502C136229726 @default.
- W1927111502 hasConceptScore W1927111502C141071460 @default.