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- W1927193003 abstract "Abstract Natural suppressor cells resident in normal human bone marrow (BM) exert potent suppressor activity on in vitro antibody responses and other immune functions. A suppressor-enriched population of BM cells can constitutively produce a soluble mediator with similar suppressor activity and kinetics as the suppressor cells. This novel BM-derived suppressor factor (BDSF) suppresses human in vitro primary antibody responses as well as lectin-activated proliferative responses. The mediator (BDSF) has a Mr of less than 1.5 kDa, contains a lipid component, and is insensitive to indomethacin treatment. The BM cells producing the factor bear the HNK-1 surface marker but not T, B, or macrophage markers. The ability of BDSF to suppress Ag-dependent IgM responses during the inductive phase makes it an ideal molecule with the potential to regulate early immune and hemopoietic events within the BM compartment." @default.
- W1927193003 created "2016-06-24" @default.
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- W1927193003 date "1988-11-01" @default.
- W1927193003 modified "2023-09-27" @default.
- W1927193003 title "Production of human bone marrow-derived suppressor factor. Effect on antibody synthesis and lectin-activated cell proliferation." @default.
- W1927193003 doi "https://doi.org/10.4049/jimmunol.141.9.3037" @default.
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