Matches in SemOpenAlex for { <https://semopenalex.org/work/W1927247650> ?p ?o ?g. }
- W1927247650 endingPage "6890" @default.
- W1927247650 startingPage "6882" @default.
- W1927247650 abstract "ABSTRACT The antimicrobial effects of copper ions and salts are well known, but the effects of cuprous oxide nanoparticles (Cu 2 O-NPs) on staphylococcal biofilms have not yet been clearly revealed. The present study evaluated Cu 2 O-NPs for their antibacterial and antibiofilm activities against heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) and vancomycin-intermediate S. aureus (VISA). Nanoscaled Cu 2 O, generated by solution phase technology, contained Cu 2 O octahedral nanoparticles. Field emission electron microscopy demonstrated particles with sizes ranging from 100 to 150 nm. Cu 2 O-NPs inhibited the growth of S. aureus and showed antibiofilm activity. The MICs and minimum biofilm inhibitory concentrations ranged from 625 μg/ml to 5,000 μg/ml and from 2,500 μg/ml to 10,000 μg/ml, respectively. Exposure of S. aureus to Cu 2 O-NPs caused leakage of the cellular constituents and increased uptake of ethidium bromide and propidium iodide. Exposure also caused a significant reduction in the overall vancomycin-BODIPY (dipyrromethene boron difluoride [4,4-difluoro-4-bora-3 a ,4 a -diaza- s -indacene] fluorescent dye) binding and a decrease in the viable cell count in the presence of 7.5% sodium chloride. Cu 2 O-NP toxicity assessment by hemolysis assay showed no cytotoxicity at 625 to 10,000 μg/ml concentrations. The results suggest that Cu 2 O-NPs exert their action by disruption of the bacterial cell membrane and can be used as effective antistaphylococcal and antibiofilm agents in diverse medical devices." @default.
- W1927247650 created "2016-06-24" @default.
- W1927247650 creator A5028648595 @default.
- W1927247650 creator A5037240707 @default.
- W1927247650 creator A5051990347 @default.
- W1927247650 creator A5080992395 @default.
- W1927247650 creator A5081303279 @default.
- W1927247650 creator A5081341631 @default.
- W1927247650 creator A5088506714 @default.
- W1927247650 date "2015-11-01" @default.
- W1927247650 modified "2023-09-23" @default.
- W1927247650 title "Antibiofilm and Membrane-Damaging Potential of Cuprous Oxide Nanoparticles against Staphylococcus aureus with Reduced Susceptibility to Vancomycin" @default.
- W1927247650 cites W1775749144 @default.
- W1927247650 cites W1911417213 @default.
- W1927247650 cites W1925153779 @default.
- W1927247650 cites W1972053765 @default.
- W1927247650 cites W1994895410 @default.
- W1927247650 cites W1997254753 @default.
- W1927247650 cites W2001760607 @default.
- W1927247650 cites W2004195877 @default.
- W1927247650 cites W2034025128 @default.
- W1927247650 cites W2039538011 @default.
- W1927247650 cites W2042133224 @default.
- W1927247650 cites W2049858732 @default.
- W1927247650 cites W2054997209 @default.
- W1927247650 cites W2062061704 @default.
- W1927247650 cites W2062329742 @default.
- W1927247650 cites W2063323488 @default.
- W1927247650 cites W2067368666 @default.
- W1927247650 cites W2087775241 @default.
- W1927247650 cites W2091881741 @default.
- W1927247650 cites W2099839947 @default.
- W1927247650 cites W2104249814 @default.
- W1927247650 cites W2109427414 @default.
- W1927247650 cites W2116378268 @default.
- W1927247650 cites W2122792108 @default.
- W1927247650 cites W2125266622 @default.
- W1927247650 cites W2125426826 @default.
- W1927247650 cites W2126915534 @default.
- W1927247650 cites W2127311884 @default.
- W1927247650 cites W2128578655 @default.
- W1927247650 cites W2129345312 @default.
- W1927247650 cites W2129744517 @default.
- W1927247650 cites W2132629057 @default.
- W1927247650 cites W2137260452 @default.
- W1927247650 cites W2144850613 @default.
- W1927247650 cites W2146967501 @default.
- W1927247650 cites W2152834335 @default.
- W1927247650 cites W2160244430 @default.
- W1927247650 cites W2163151727 @default.
- W1927247650 cites W2165861026 @default.
- W1927247650 cites W2351871382 @default.
- W1927247650 cites W4234644625 @default.
- W1927247650 doi "https://doi.org/10.1128/aac.01440-15" @default.
- W1927247650 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4604377" @default.
- W1927247650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26303796" @default.
- W1927247650 hasPublicationYear "2015" @default.
- W1927247650 type Work @default.
- W1927247650 sameAs 1927247650 @default.
- W1927247650 citedByCount "37" @default.
- W1927247650 countsByYear W19272476502017 @default.
- W1927247650 countsByYear W19272476502018 @default.
- W1927247650 countsByYear W19272476502019 @default.
- W1927247650 countsByYear W19272476502020 @default.
- W1927247650 countsByYear W19272476502021 @default.
- W1927247650 countsByYear W19272476502022 @default.
- W1927247650 countsByYear W19272476502023 @default.
- W1927247650 crossrefType "journal-article" @default.
- W1927247650 hasAuthorship W1927247650A5028648595 @default.
- W1927247650 hasAuthorship W1927247650A5037240707 @default.
- W1927247650 hasAuthorship W1927247650A5051990347 @default.
- W1927247650 hasAuthorship W1927247650A5080992395 @default.
- W1927247650 hasAuthorship W1927247650A5081303279 @default.
- W1927247650 hasAuthorship W1927247650A5081341631 @default.
- W1927247650 hasAuthorship W1927247650A5088506714 @default.
- W1927247650 hasBestOaLocation W19272476501 @default.
- W1927247650 hasConcept C109316439 @default.
- W1927247650 hasConcept C13965031 @default.
- W1927247650 hasConcept C176947019 @default.
- W1927247650 hasConcept C178790620 @default.
- W1927247650 hasConcept C179104552 @default.
- W1927247650 hasConcept C185592680 @default.
- W1927247650 hasConcept C190283241 @default.
- W1927247650 hasConcept C202751555 @default.
- W1927247650 hasConcept C2775934118 @default.
- W1927247650 hasConcept C2776907736 @default.
- W1927247650 hasConcept C2778870691 @default.
- W1927247650 hasConcept C2778980435 @default.
- W1927247650 hasConcept C2779489039 @default.
- W1927247650 hasConcept C31573885 @default.
- W1927247650 hasConcept C4937899 @default.
- W1927247650 hasConcept C523546767 @default.
- W1927247650 hasConcept C54355233 @default.
- W1927247650 hasConcept C552990157 @default.
- W1927247650 hasConcept C55493867 @default.
- W1927247650 hasConcept C58123911 @default.
- W1927247650 hasConcept C86803240 @default.
- W1927247650 hasConcept C89423630 @default.