FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1927296860> ?p ?o ?g. }

• W1927296860 endingPage "6549" @default.
• W1927296860 startingPage "6542" @default.
• W1927296860 abstract "Macrophages demonstrate a high level of plasticity, with the ability to undergo dynamic transition between M1 and M2 polarized phenotypes. The role of microRNAs (miRNAs) in regulating macrophage polarization has been largely undefined. In this study, we found that miRNA let-7c is expressed at a higher level in M-BMM (M2 macrophages) than in GM-BMM (M1 macrophages). let-7c levels are also greater in alveolar macrophages from fibrotic lungs as compared with those from normal lungs. let-7c expression was decreased when M-BMM converted to GM-BMM, whereas it increased when GM-BMM converted to M-BMM. LPS stimulation reduced let-7c expression in M-BMM. We found that overexpression of let-7c in GM-BMM diminished M1 phenotype expression while promoting polarization to the M2 phenotype. In contrast, knockdown of let-7c in M-BMM promoted M1 polarization and diminished M2 phenotype expression. We found that let-7c targets C/EBP-δ, a transcriptional factor that plays an important role in inflammatory response. Furthermore, we found that let-7c regulates bactericidal and phagocytic activities of macrophages, two functional phenotypes implicated in macrophage polarization. Our data suggest that the miRNA let-7c plays an important role in regulating macrophage polarization." @default.
• W1927296860 created "2016-06-24" @default.
• W1927296860 creator A5014333112 @default.
• W1927296860 creator A5027855795 @default.
• W1927296860 creator A5028568020 @default.
• W1927296860 creator A5034933519 @default.
• W1927296860 creator A5046900680 @default.
• W1927296860 creator A5047037927 @default.
• W1927296860 creator A5058342595 @default.
• W1927296860 creator A5090740656 @default.
• W1927296860 date "2013-05-10" @default.
• W1927296860 modified "2023-10-15" @default.
• W1927296860 title "MicroRNA let-7c Regulates Macrophage Polarization" @default.
• W1927296860 cites W1833918098 @default.
• W1927296860 cites W1901329997 @default.
• W1927296860 cites W1920303762 @default.
• W1927296860 cites W1923917571 @default.
• W1927296860 cites W1942388905 @default.
• W1927296860 cites W1952855042 @default.
• W1927296860 cites W1965494606 @default.
• W1927296860 cites W1967369695 @default.
• W1927296860 cites W1976556343 @default.
• W1927296860 cites W1979021654 @default.
• W1927296860 cites W1979982103 @default.
• W1927296860 cites W1984061476 @default.
• W1927296860 cites W1984935494 @default.
• W1927296860 cites W2008945738 @default.
• W1927296860 cites W2015141049 @default.
• W1927296860 cites W2015858554 @default.
• W1927296860 cites W2031842372 @default.
• W1927296860 cites W2036584139 @default.
• W1927296860 cites W2037572861 @default.
• W1927296860 cites W2039342356 @default.
• W1927296860 cites W2053391380 @default.
• W1927296860 cites W2054472394 @default.
• W1927296860 cites W2065769697 @default.
• W1927296860 cites W2067647130 @default.
• W1927296860 cites W2068793888 @default.
• W1927296860 cites W2071430851 @default.
• W1927296860 cites W2077124851 @default.
• W1927296860 cites W2079590189 @default.
• W1927296860 cites W2081810806 @default.
• W1927296860 cites W2083100127 @default.
• W1927296860 cites W2086627977 @default.
• W1927296860 cites W2098672681 @default.
• W1927296860 cites W2098966232 @default.
• W1927296860 cites W2100820895 @default.
• W1927296860 cites W2106737444 @default.
• W1927296860 cites W2110780943 @default.
• W1927296860 cites W2111920665 @default.
• W1927296860 cites W2115048931 @default.
• W1927296860 cites W2119013116 @default.
• W1927296860 cites W2120351666 @default.
• W1927296860 cites W2121874550 @default.
• W1927296860 cites W2123509232 @default.
• W1927296860 cites W2132093971 @default.
• W1927296860 cites W2133536768 @default.
• W1927296860 cites W2136160240 @default.
• W1927296860 cites W2141077333 @default.
• W1927296860 cites W2143092625 @default.
• W1927296860 cites W2143719912 @default.
• W1927296860 cites W2143766145 @default.
• W1927296860 cites W2144310026 @default.
• W1927296860 cites W2146858822 @default.
• W1927296860 cites W2151948277 @default.
• W1927296860 cites W2152310279 @default.
• W1927296860 cites W2152609353 @default.
• W1927296860 cites W2154841861 @default.
• W1927296860 cites W2156023352 @default.
• W1927296860 cites W2167589136 @default.
• W1927296860 cites W2171849700 @default.
• W1927296860 cites W2172089049 @default.
• W1927296860 doi "https://doi.org/10.4049/jimmunol.1202496" @default.
• W1927296860 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3679284" @default.
• W1927296860 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23667114" @default.
• W1927296860 hasPublicationYear "2013" @default.
• W1927296860 type Work @default.
• W1927296860 sameAs 1927296860 @default.
• W1927296860 citedByCount "229" @default.
• W1927296860 countsByYear W19272968602013 @default.
• W1927296860 countsByYear W19272968602014 @default.
• W1927296860 countsByYear W19272968602015 @default.
• W1927296860 countsByYear W19272968602016 @default.
• W1927296860 countsByYear W19272968602017 @default.
• W1927296860 countsByYear W19272968602018 @default.
• W1927296860 countsByYear W19272968602019 @default.
• W1927296860 countsByYear W19272968602020 @default.
• W1927296860 countsByYear W19272968602021 @default.
• W1927296860 countsByYear W19272968602022 @default.
• W1927296860 countsByYear W19272968602023 @default.
• W1927296860 crossrefType "journal-article" @default.
• W1927296860 hasAuthorship W1927296860A5014333112 @default.
• W1927296860 hasAuthorship W1927296860A5027855795 @default.
• W1927296860 hasAuthorship W1927296860A5028568020 @default.
• W1927296860 hasAuthorship W1927296860A5034933519 @default.
• W1927296860 hasAuthorship W1927296860A5046900680 @default.
• W1927296860 hasAuthorship W1927296860A5047037927 @default.
• W1927296860 hasAuthorship W1927296860A5058342595 @default.

• next