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- W1927336306 abstract "A 59-year-old male patient was diagnosed as multiple myeloma in 2005 and received chemotherapy consisting of thalidomide, cyclophosphamide, and dexamethasone. The patient subsequently received high-dose melphalan followed by autologous stem cell transplantation and maintenance therapy with thalidomide. During the follow-up, the patient developed fever and cytopenias in 2012. The work up revealed 55% blasts in the marrow with myeloid phenotype leading to a diagnosis of acute myeloma leukaemia (AML). The karyotype was normal (46,XY) on conventional cytogenetics. The therapy was initiated, however, the patient expired within 1 month of diagnosis. The treatment related factors like alkylating agents are usually taken as the responsible agents for therapy-related AML, however, recent studies have proposed a multifactorial pathogenesis of leukaemic transformation in multiple myeloma." @default.
- W1927336306 created "2016-06-24" @default.
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- W1927336306 date "2015-05-29" @default.
- W1927336306 modified "2023-09-27" @default.
- W1927336306 title "AML transformation after autologous stem cell transplant for multiple myeloma" @default.
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- W1927336306 doi "https://doi.org/10.1136/bcr-2015-210024" @default.
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