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- W1927532110 abstract "The in vitro effect of the hexane extract from branches of Glycosmis prava on LPSinduced macrophage activation was investigated. Murine macrophages, J774A.1cells, were used in this study. The extract suppressed nitric oxide production from LPS-activated J774A.1 cells in a concentration dependent manner with IC50 44.70 μg/ml. It decreased the mRNA expression of the inducible nitric oxide synthase (iNOS) which is responsible for NO production as well as the cyclo-oxygenase 2 (COX-2) which is responsible for prostaglandins (PGs) synthesis in these activated macrophages. The extract also inhibited the mRNA expression of pro-inflammatory cytokines, including TNF-α, IL-1β and IL-6. The results from this study indicated that the hexane extract from G. parva may have anti-inflammatory activities against activated macrophages which play a significant role during inflammatory process." @default.
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- W1927532110 date "2010-01-01" @default.
- W1927532110 modified "2023-09-28" @default.
- W1927532110 title "Effects of the Hexane Extract from Glycosmis parva on LPS-induced Macrophage Activation" @default.
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