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• W1927621390 endingPage "1333" @default.
• W1927621390 startingPage "1323" @default.
• W1927621390 abstract "Abstract Phosphatidylinositol 4,5–biphosphate (PIP2) is a cell membrane phosphoinositide crucial for cell signaling and activation. Indeed, PIP2 is a pivotal source for second messenger generation and controlling the activity of several proteins regulating cytoskeleton reorganization. Despite its critical role in T cell activation, the molecular mechanisms regulating PIP2 turnover remain largely unknown. In human primary CD4+ T lymphocytes, we have recently demonstrated that CD28 costimulatory receptor is crucial for regulating PIP2 turnover by allowing the recruitment and activation of the lipid kinase phosphatidylinositol 4–phosphate 5–kinase (PIP5Kα). We also identified PIP5Kα as a key modulator of CD28 costimulatory signals leading to the efficient T cell activation. In this study, we extend these data by demonstrating that PIP5Kα recruitment and activation is essential for CD28-mediated cytoskeleton rearrangement necessary for organizing a complete signaling compartment leading to downstream signaling functions. We also identified Vav1 as the linker molecule that couples the C-terminal proline-rich motif of CD28 to the recruitment and activation of PIP5Kα, which in turn cooperates with Vav1 in regulating actin polymerization and CD28 signaling functions." @default.
• W1927621390 created "2016-06-24" @default.
• W1927621390 creator A5003992747 @default.
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• W1927621390 creator A5059847691 @default.
• W1927621390 creator A5072898678 @default.
• W1927621390 creator A5083405572 @default.
• W1927621390 date "2015-02-01" @default.
• W1927621390 modified "2023-10-16" @default.
• W1927621390 title "Phosphatidylinositol 4–Phosphate 5–Kinase α and Vav1 Mutual Cooperation in CD28-Mediated Actin Remodeling and Signaling Functions" @default.
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• W1927621390 doi "https://doi.org/10.4049/jimmunol.1401643" @default.
• W1927621390 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25539813" @default.
• W1927621390 hasPublicationYear "2015" @default.
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