Matches in SemOpenAlex for { <https://semopenalex.org/work/W1927646875> ?p ?o ?g. }
- W1927646875 endingPage "4559" @default.
- W1927646875 startingPage "4553" @default.
- W1927646875 abstract "There is ample experimental evidence that polymorphonuclear neutrophils (PMN) play a critical role in the pathogenesis of the adult respiratory distress syndrome (ARDS). Since interleukin-8 (IL-8) is a strong chemotactic factor for PMN, we measured IL-8 levels in plasma and bronchoalveolar lavage (BAL) fluid of 18 patients, 12 with ARDS and 6 with severe pneumonia uncomplicated by ARDS, all of whom had an increased number of PMN in BAL fluid. Seven healthy subjects served as controls. We found elevated levels of IL-8 in the alveolar spaces of all patients tested. Elevated BAL IL-8 levels were related to a fatal outcome and the presence of shock and correlated with a general clinical severity index (simplified acute physiological score). BAL fluid levels of IL-8 were significantly higher in patients with ARDS than in patients with pneumonia. In plasma, IL-8 levels were increased similarly in all patients and did not correlate with survival or the presence of shock. The BAL fluid-to-plasma ratio of IL-8 was significantly greater than that of tumor necrosis factor alpha, indicating higher local production of IL-8. Moreover, the presence of a primed subpopulation of blood PMN with respect to H2O2 production indicates that IL-8 may contribute to the neutrophil-mediated process in the pathogenesis of ARDS and pneumonia." @default.
- W1927646875 created "2016-06-24" @default.
- W1927646875 creator A5022643483 @default.
- W1927646875 creator A5024066407 @default.
- W1927646875 creator A5035285867 @default.
- W1927646875 creator A5042086006 @default.
- W1927646875 creator A5057977180 @default.
- W1927646875 creator A5065319132 @default.
- W1927646875 creator A5070531576 @default.
- W1927646875 date "1993-11-01" @default.
- W1927646875 modified "2023-10-15" @default.
- W1927646875 title "High levels of interleukin-8 in the blood and alveolar spaces of patients with pneumonia and adult respiratory distress syndrome" @default.
- W1927646875 cites W1489136175 @default.
- W1927646875 cites W1512071494 @default.
- W1927646875 cites W1571641225 @default.
- W1927646875 cites W1606334450 @default.
- W1927646875 cites W1607497616 @default.
- W1927646875 cites W169397445 @default.
- W1927646875 cites W1843855945 @default.
- W1927646875 cites W1843968746 @default.
- W1927646875 cites W1864963307 @default.
- W1927646875 cites W1879207397 @default.
- W1927646875 cites W1903742027 @default.
- W1927646875 cites W1904507585 @default.
- W1927646875 cites W1918081901 @default.
- W1927646875 cites W1929579570 @default.
- W1927646875 cites W1983405778 @default.
- W1927646875 cites W1997385454 @default.
- W1927646875 cites W2005357317 @default.
- W1927646875 cites W2010284674 @default.
- W1927646875 cites W2023404773 @default.
- W1927646875 cites W2025442119 @default.
- W1927646875 cites W2048519644 @default.
- W1927646875 cites W2071258337 @default.
- W1927646875 cites W2072036820 @default.
- W1927646875 cites W2083058447 @default.
- W1927646875 cites W2100295490 @default.
- W1927646875 cites W2103401040 @default.
- W1927646875 cites W2103849644 @default.
- W1927646875 cites W2104351898 @default.
- W1927646875 cites W2107743100 @default.
- W1927646875 cites W2123884323 @default.
- W1927646875 cites W2147657681 @default.
- W1927646875 cites W2157318688 @default.
- W1927646875 cites W2159833023 @default.
- W1927646875 cites W2160892616 @default.
- W1927646875 cites W2161753403 @default.
- W1927646875 cites W2164194120 @default.
- W1927646875 cites W2170960160 @default.
- W1927646875 cites W2311551614 @default.
- W1927646875 cites W2400270607 @default.
- W1927646875 cites W2413988702 @default.
- W1927646875 doi "https://doi.org/10.1128/iai.61.11.4553-4559.1993" @default.
- W1927646875 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/281204" @default.
- W1927646875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8406851" @default.
- W1927646875 hasPublicationYear "1993" @default.
- W1927646875 type Work @default.
- W1927646875 sameAs 1927646875 @default.
- W1927646875 citedByCount "206" @default.
- W1927646875 countsByYear W19276468752012 @default.
- W1927646875 countsByYear W19276468752013 @default.
- W1927646875 countsByYear W19276468752014 @default.
- W1927646875 countsByYear W19276468752015 @default.
- W1927646875 countsByYear W19276468752016 @default.
- W1927646875 countsByYear W19276468752017 @default.
- W1927646875 countsByYear W19276468752018 @default.
- W1927646875 countsByYear W19276468752019 @default.
- W1927646875 countsByYear W19276468752020 @default.
- W1927646875 countsByYear W19276468752021 @default.
- W1927646875 countsByYear W19276468752022 @default.
- W1927646875 countsByYear W19276468752023 @default.
- W1927646875 crossrefType "journal-article" @default.
- W1927646875 hasAuthorship W1927646875A5022643483 @default.
- W1927646875 hasAuthorship W1927646875A5024066407 @default.
- W1927646875 hasAuthorship W1927646875A5035285867 @default.
- W1927646875 hasAuthorship W1927646875A5042086006 @default.
- W1927646875 hasAuthorship W1927646875A5057977180 @default.
- W1927646875 hasAuthorship W1927646875A5065319132 @default.
- W1927646875 hasAuthorship W1927646875A5070531576 @default.
- W1927646875 hasBestOaLocation W19276468751 @default.
- W1927646875 hasConcept C126322002 @default.
- W1927646875 hasConcept C141983124 @default.
- W1927646875 hasConcept C17991360 @default.
- W1927646875 hasConcept C203014093 @default.
- W1927646875 hasConcept C2776178081 @default.
- W1927646875 hasConcept C2776348555 @default.
- W1927646875 hasConcept C2777714996 @default.
- W1927646875 hasConcept C2777914695 @default.
- W1927646875 hasConcept C2777961210 @default.
- W1927646875 hasConcept C2778384902 @default.
- W1927646875 hasConcept C2780942790 @default.
- W1927646875 hasConcept C2781300812 @default.
- W1927646875 hasConcept C42219234 @default.
- W1927646875 hasConcept C71924100 @default.
- W1927646875 hasConcept C90924648 @default.
- W1927646875 hasConceptScore W1927646875C126322002 @default.
- W1927646875 hasConceptScore W1927646875C141983124 @default.
- W1927646875 hasConceptScore W1927646875C17991360 @default.