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• W1927667480 startingPage "2606" @default.
• W1927667480 abstract "Abstract IL-15 is a T cell growth factor that shares many biological activities with IL-2 and uses the same β/γ polypeptides of the IL-2R complex for signal transduction. Accumulating evidence implicates an important role for this cytokine in the inflammatory response of the host. Consistent with such a role, IL-15 has been shown to be a chemoattractant for T lymphocytes, NK cells, and neutrophils. Extending these observations, we now show that IL-15 is a potent inducer of CC-, CXC-, and C-type chemokines in T lymphocytes. In addition, we demonstrate that IL-15 induces CC chemokine receptors, but not CXC chemokine receptors, in a dose-dependent manner. Thus, our findings suggest that the proinflammatory effects of IL-15 at least in part may be due to the induction of chemokines and their receptors in T cells. Furthermore, we demonstrate that IL-15 promotes entry and replication of macrophage-tropic HIV in T lymphocytes and suggest a plausible mechanism by which IL-15, a cytokine that is elevated in HIV-infected individuals, may promote the transition of HIV displaying the M-tropic phenotype primarily associated with the initial transmission into the T cell-tropic phenotype that predominates as the disease progresses." @default.
• W1927667480 created "2016-06-24" @default.
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• W1927667480 date "1999-03-01" @default.
• W1927667480 modified "2023-10-05" @default.
• W1927667480 title "IL-15 Induces the Expression of Chemokines and Their Receptors in T Lymphocytes" @default.
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• W1927667480 doi "https://doi.org/10.4049/jimmunol.162.5.2606" @default.
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