Matches in SemOpenAlex for { <https://semopenalex.org/work/W1927697103> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W1927697103 endingPage "1494" @default.
- W1927697103 startingPage "1492" @default.
- W1927697103 abstract "Abstract It has been shown that all three classes of interferons enhance the expression of the major histocompatibility class I antigens (HLA-A,B,C;H-2) on a wide variety of cell types (1-10). However, their effect on the expression of the class II antigens (HLA-DR, Ia), which play a major part in cellular interactions that initiate an immune response, is more controversial. The predominate findings have been that the interferons specifically increase the synthesis and expression of only the class I antigens (3, 4, 6, 8, 10, 11). We report here that recombinant interferon-gamma (IFN-gamma) increases the synthesis and expression of the HLA-DR (la-like) antigens as well as beta 2-microglobulin (beta 2-m), a low m.w. subunit of HLA, on human melanoma cells. No increase in HLA-DR was detected on these melanoma cells with leukocyte interferon (IFN-alpha) at doses 400 times higher than the maximum dose of IFN-gamma. These findings were extended to show that pure IFN-gamma also increases the expression of the HLA-DR antigens on normal peripheral blood monocytes, whereas recombinant IFN-alpha at a similar dose had little effect on the expression of this surface antigen. These findings suggest a specialized role for IFN-gamma in immune regulation in comparison with IFN-alpha." @default.
- W1927697103 created "2016-06-24" @default.
- W1927697103 creator A5084419539 @default.
- W1927697103 creator A5084780646 @default.
- W1927697103 date "1983-04-01" @default.
- W1927697103 modified "2023-10-18" @default.
- W1927697103 title "Recombinant interferon-gamma increases HLA-DR synthesis and expression." @default.
- W1927697103 doi "https://doi.org/10.4049/jimmunol.130.4.1492" @default.
- W1927697103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6403609" @default.
- W1927697103 hasPublicationYear "1983" @default.
- W1927697103 type Work @default.
- W1927697103 sameAs 1927697103 @default.
- W1927697103 citedByCount "407" @default.
- W1927697103 countsByYear W19276971032012 @default.
- W1927697103 countsByYear W19276971032013 @default.
- W1927697103 countsByYear W19276971032014 @default.
- W1927697103 countsByYear W19276971032015 @default.
- W1927697103 countsByYear W19276971032016 @default.
- W1927697103 countsByYear W19276971032017 @default.
- W1927697103 countsByYear W19276971032018 @default.
- W1927697103 countsByYear W19276971032019 @default.
- W1927697103 countsByYear W19276971032020 @default.
- W1927697103 countsByYear W19276971032021 @default.
- W1927697103 countsByYear W19276971032022 @default.
- W1927697103 countsByYear W19276971032023 @default.
- W1927697103 crossrefType "journal-article" @default.
- W1927697103 hasAuthorship W1927697103A5084419539 @default.
- W1927697103 hasAuthorship W1927697103A5084780646 @default.
- W1927697103 hasBestOaLocation W19276971031 @default.
- W1927697103 hasConcept C104317684 @default.
- W1927697103 hasConcept C147483822 @default.
- W1927697103 hasConcept C153911025 @default.
- W1927697103 hasConcept C188280979 @default.
- W1927697103 hasConcept C199360897 @default.
- W1927697103 hasConcept C202965653 @default.
- W1927697103 hasConcept C203014093 @default.
- W1927697103 hasConcept C207936829 @default.
- W1927697103 hasConcept C2776174256 @default.
- W1927697103 hasConcept C2776178377 @default.
- W1927697103 hasConcept C2780841837 @default.
- W1927697103 hasConcept C2909179924 @default.
- W1927697103 hasConcept C2910492473 @default.
- W1927697103 hasConcept C40767141 @default.
- W1927697103 hasConcept C41008148 @default.
- W1927697103 hasConcept C54355233 @default.
- W1927697103 hasConcept C86803240 @default.
- W1927697103 hasConcept C8891405 @default.
- W1927697103 hasConceptScore W1927697103C104317684 @default.
- W1927697103 hasConceptScore W1927697103C147483822 @default.
- W1927697103 hasConceptScore W1927697103C153911025 @default.
- W1927697103 hasConceptScore W1927697103C188280979 @default.
- W1927697103 hasConceptScore W1927697103C199360897 @default.
- W1927697103 hasConceptScore W1927697103C202965653 @default.
- W1927697103 hasConceptScore W1927697103C203014093 @default.
- W1927697103 hasConceptScore W1927697103C207936829 @default.
- W1927697103 hasConceptScore W1927697103C2776174256 @default.
- W1927697103 hasConceptScore W1927697103C2776178377 @default.
- W1927697103 hasConceptScore W1927697103C2780841837 @default.
- W1927697103 hasConceptScore W1927697103C2909179924 @default.
- W1927697103 hasConceptScore W1927697103C2910492473 @default.
- W1927697103 hasConceptScore W1927697103C40767141 @default.
- W1927697103 hasConceptScore W1927697103C41008148 @default.
- W1927697103 hasConceptScore W1927697103C54355233 @default.
- W1927697103 hasConceptScore W1927697103C86803240 @default.
- W1927697103 hasConceptScore W1927697103C8891405 @default.
- W1927697103 hasIssue "4" @default.
- W1927697103 hasLocation W19276971031 @default.
- W1927697103 hasLocation W19276971032 @default.
- W1927697103 hasOpenAccess W1927697103 @default.
- W1927697103 hasPrimaryLocation W19276971031 @default.
- W1927697103 hasRelatedWork W1989855601 @default.
- W1927697103 hasRelatedWork W2060941543 @default.
- W1927697103 hasRelatedWork W2061708895 @default.
- W1927697103 hasRelatedWork W2069074014 @default.
- W1927697103 hasRelatedWork W2087893797 @default.
- W1927697103 hasRelatedWork W2097991080 @default.
- W1927697103 hasRelatedWork W2130120717 @default.
- W1927697103 hasRelatedWork W2395974103 @default.
- W1927697103 hasRelatedWork W2410598814 @default.
- W1927697103 hasRelatedWork W2417719631 @default.
- W1927697103 hasVolume "130" @default.
- W1927697103 isParatext "false" @default.
- W1927697103 isRetracted "false" @default.
- W1927697103 magId "1927697103" @default.
- W1927697103 workType "article" @default.