FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W192777135> ?p ?o ?g. }

• W192777135 abstract "Parathyroid hormone-related protein (PTHrP) is a ubiquitous and highly conserved vasoactive peptide whose role and regulation in normal physiology remain an enigma. Recently, we demonstrated that low-dose endotoxin (LPS) induces intrasplenic, but not systemic, levels of PTHrP; and that tumor necrosis factor, a pro-inflammatory cytokine, is the major mediator of this effect. We have therefore hypothesized that, with higher, lethal doses of endotoxin, PTHrP could be induced in multiple tissues to such a degree that it could contribute to the lethality of septic shock.Northern blot analysis was used to measure PTHrP mRNA levels in vital organs of rats after administration of a near lethal dose (5 mg/250 g) of LPS (or vehicle alone). Plasma levels of PTHrP were also measured by immunoradiometric assay. The ability of the immunoglobulin fraction of two different PTHrP(1-34) antisera to protect from LPS-induced lethality was also studied in mice using survival analysis.In response to a near-lethal dose of endotoxin, PTHrP mRNA levels increased acutely in every vital organ examined (spleen, lung, heart, kidney, and liver). Circulating levels of PTHrP also increased, peaking 2 hr after administration of high-dose endotoxin. Passive immunization of mice with anti-PTHrP(1-34) antibody 6 hr prior to administration of a lethal dose of LPS protected mice from endotoxin-induced death (p < 0.00005).These results suggest that PTHrP belongs to the cascade of pro-inflammatory cytokines induced during lethal endotoxemia that is responsible for the toxic effects of LPS." @default.
• W192777135 created "2016-06-24" @default.
• W192777135 creator A5013703333 @default.
• W192777135 creator A5040146514 @default.
• W192777135 creator A5048434963 @default.
• W192777135 creator A5051357897 @default.
• W192777135 creator A5051847291 @default.
• W192777135 date "1996-03-01" @default.
• W192777135 modified "2023-10-13" @default.
• W192777135 title "Parathyroid Hormone-Related Protein Is Induced during Lethal Endotoxemia and Contributes to Endotoxin-Induced Mortality in Rodents" @default.
• W192777135 cites W1552576051 @default.
• W192777135 cites W1579897694 @default.
• W192777135 cites W187123369 @default.
• W192777135 cites W1946578458 @default.
• W192777135 cites W1963933110 @default.
• W192777135 cites W1972650602 @default.
• W192777135 cites W1985157188 @default.
• W192777135 cites W1999246265 @default.
• W192777135 cites W2001776741 @default.
• W192777135 cites W2007671540 @default.
• W192777135 cites W2016032320 @default.
• W192777135 cites W2018931269 @default.
• W192777135 cites W2033691415 @default.
• W192777135 cites W2036753536 @default.
• W192777135 cites W2038434279 @default.
• W192777135 cites W2046102646 @default.
• W192777135 cites W2060724258 @default.
• W192777135 cites W2062824264 @default.
• W192777135 cites W2065699321 @default.
• W192777135 cites W2067338751 @default.
• W192777135 cites W2070908474 @default.
• W192777135 cites W2089744756 @default.
• W192777135 cites W2150554044 @default.
• W192777135 cites W2265083863 @default.
• W192777135 cites W2273304878 @default.
• W192777135 cites W4297953642 @default.
• W192777135 doi "https://doi.org/10.1007/bf03401617" @default.
• W192777135 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2230122" @default.
• W192777135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8726463" @default.
• W192777135 hasPublicationYear "1996" @default.
• W192777135 type Work @default.
• W192777135 sameAs 192777135 @default.
• W192777135 citedByCount "19" @default.
• W192777135 countsByYear W1927771352013 @default.
• W192777135 countsByYear W1927771352014 @default.
• W192777135 countsByYear W1927771352017 @default.
• W192777135 crossrefType "journal-article" @default.
• W192777135 hasAuthorship W192777135A5013703333 @default.
• W192777135 hasAuthorship W192777135A5040146514 @default.
• W192777135 hasAuthorship W192777135A5048434963 @default.
• W192777135 hasAuthorship W192777135A5051357897 @default.
• W192777135 hasAuthorship W192777135A5051847291 @default.
• W192777135 hasBestOaLocation W1927771351 @default.
• W192777135 hasConcept C126322002 @default.
• W192777135 hasConcept C134018914 @default.
• W192777135 hasConcept C176685330 @default.
• W192777135 hasConcept C17991360 @default.
• W192777135 hasConcept C203014093 @default.
• W192777135 hasConcept C2777544843 @default.
• W192777135 hasConcept C2778690821 @default.
• W192777135 hasConcept C2778754761 @default.
• W192777135 hasConcept C2778758028 @default.
• W192777135 hasConcept C2778828131 @default.
• W192777135 hasConcept C2780091579 @default.
• W192777135 hasConcept C2780931953 @default.
• W192777135 hasConcept C2781208988 @default.
• W192777135 hasConcept C33070731 @default.
• W192777135 hasConcept C519063684 @default.
• W192777135 hasConcept C71924100 @default.
• W192777135 hasConcept C86803240 @default.
• W192777135 hasConceptScore W192777135C126322002 @default.
• W192777135 hasConceptScore W192777135C134018914 @default.
• W192777135 hasConceptScore W192777135C176685330 @default.
• W192777135 hasConceptScore W192777135C17991360 @default.
• W192777135 hasConceptScore W192777135C203014093 @default.
• W192777135 hasConceptScore W192777135C2777544843 @default.
• W192777135 hasConceptScore W192777135C2778690821 @default.
• W192777135 hasConceptScore W192777135C2778754761 @default.
• W192777135 hasConceptScore W192777135C2778758028 @default.
• W192777135 hasConceptScore W192777135C2778828131 @default.
• W192777135 hasConceptScore W192777135C2780091579 @default.
• W192777135 hasConceptScore W192777135C2780931953 @default.
• W192777135 hasConceptScore W192777135C2781208988 @default.
• W192777135 hasConceptScore W192777135C33070731 @default.
• W192777135 hasConceptScore W192777135C519063684 @default.
• W192777135 hasConceptScore W192777135C71924100 @default.
• W192777135 hasConceptScore W192777135C86803240 @default.
• W192777135 hasLocation W1927771351 @default.
• W192777135 hasLocation W1927771352 @default.
• W192777135 hasLocation W1927771353 @default.
• W192777135 hasOpenAccess W192777135 @default.
• W192777135 hasPrimaryLocation W1927771351 @default.
• W192777135 hasRelatedWork W1493182567 @default.
• W192777135 hasRelatedWork W192777135 @default.
• W192777135 hasRelatedWork W1977918131 @default.
• W192777135 hasRelatedWork W2007888586 @default.
• W192777135 hasRelatedWork W2096284471 @default.
• W192777135 hasRelatedWork W2124552117 @default.
• W192777135 hasRelatedWork W2127733257 @default.
• W192777135 hasRelatedWork W2151614054 @default.

• next