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• W1927788271 endingPage "11876" @default.
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• W1927788271 abstract "Bexarotene-activated retinoid X receptors (RXRs) ameliorate memory deficits in Alzheimer's disease mouse models, including mice expressing human apolipoprotein E (APOE) isoforms. The goal of this study was to gain further insight into molecular mechanisms whereby ligand-activated RXR can affect or restore cognitive functions. We used an unbiased approach to discover genome-wide changes in RXR cistrome (ChIP-Seq) and gene expression profile (RNA-Seq) in response to bexarotene in the cortex of APOE4 mice. Functional categories enriched in both datasets revealed that bexarotene-liganded RXR affected signaling pathways associated with neurogenesis and neuron projection development. To further validate the significance of RXR for these functions, we used mouse embryonic stem (ES) cells, primary neurons, and APOE3 and APOE4 mice treated with bexarotene. In vitro data from ES cells confirmed that bexarotene-activated RXR affected neuronal development at different levels, including proliferation of neural progenitors and neuronal differentiation, and stimulated neurite outgrowth. This effect was validated in vivo by demonstrating an increased number of neuronal progenitors after bexarotene treatment in the dentate gyrus of APOE3 and APOE4 mice. In primary neurons, bexarotene enhanced the dendritic complexity characterized by increased branching, intersections, and bifurcations. This effect was confirmed by in vivo studies demonstrating that bexarotene significantly improved the compromised dendritic structure in the hippocampus of APOE4 mice. We conclude that bexarotene-activated RXRs promote genetic programs involved in the neurogenesis and development of neuronal projections and these results have significance for the improvement of cognitive deficits.Bexarotene-activated retinoid X receptors (RXRs) ameliorate memory deficits in Alzheimer's disease mouse models, including mice expressing human apolipoprotein E (APOE) isoforms. The goal of this study was to gain further insight into molecular mechanisms whereby ligand-activated RXR can affect or restore cognitive functions. We used an unbiased approach to discover genome-wide changes in RXR cistrome (ChIP-Seq) and gene expression profile (RNA-Seq) in response to bexarotene in the cortex of APOE4 mice. Functional categories enriched in both datasets revealed that liganded RXR affected signaling pathways associated with neurogenesis and neuron projection development. The significance of RXR for these functions was validated in mouse embryonic stem cells, primary neurons, and APOE3 and APOE4 mice treated with bexarotene." @default.
• W1927788271 created "2016-06-24" @default.
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• W1927788271 date "2015-08-26" @default.
• W1927788271 modified "2023-09-26" @default.
• W1927788271 title "Bexarotene-Activated Retinoid X Receptors Regulate Neuronal Differentiation and Dendritic Complexity" @default.
• W1927788271 cites W1487168219 @default.
• W1927788271 cites W1554209941 @default.
• W1927788271 cites W1593033681 @default.
• W1927788271 cites W1945460049 @default.
• W1927788271 cites W1963964013 @default.
• W1927788271 cites W1965811760 @default.
• W1927788271 cites W1968651652 @default.
• W1927788271 cites W1972012981 @default.
• W1927788271 cites W1972229580 @default.
• W1927788271 cites W1973756832 @default.
• W1927788271 cites W1976111179 @default.
• W1927788271 cites W1977547378 @default.
• W1927788271 cites W1979843262 @default.
• W1927788271 cites W1983610576 @default.
• W1927788271 cites W1984059331 @default.
• W1927788271 cites W1984475127 @default.
• W1927788271 cites W1985991976 @default.
• W1927788271 cites W1987052134 @default.
• W1927788271 cites W1994554610 @default.
• W1927788271 cites W1996457468 @default.
• W1927788271 cites W1998641354 @default.
• W1927788271 cites W1999631936 @default.
• W1927788271 cites W2003798182 @default.
• W1927788271 cites W2008496629 @default.
• W1927788271 cites W2014490965 @default.
• W1927788271 cites W2016648950 @default.
• W1927788271 cites W2019928465 @default.
• W1927788271 cites W2027850279 @default.
• W1927788271 cites W2029763221 @default.
• W1927788271 cites W2030828404 @default.
• W1927788271 cites W2032345961 @default.
• W1927788271 cites W2034028998 @default.
• W1927788271 cites W2036034523 @default.
• W1927788271 cites W2040193459 @default.
• W1927788271 cites W2042421739 @default.
• W1927788271 cites W2047562193 @default.
• W1927788271 cites W2048619491 @default.
• W1927788271 cites W2050406525 @default.
• W1927788271 cites W2051173215 @default.
• W1927788271 cites W2063967205 @default.
• W1927788271 cites W2064452627 @default.
• W1927788271 cites W2066673859 @default.
• W1927788271 cites W2070030133 @default.
• W1927788271 cites W2072822958 @default.
• W1927788271 cites W2080777953 @default.
• W1927788271 cites W2081388499 @default.
• W1927788271 cites W2081893125 @default.
• W1927788271 cites W2083436346 @default.
• W1927788271 cites W2085878806 @default.
• W1927788271 cites W2086486464 @default.
• W1927788271 cites W2087128308 @default.
• W1927788271 cites W2090966154 @default.
• W1927788271 cites W2091997230 @default.
• W1927788271 cites W2101093278 @default.
• W1927788271 cites W2107953789 @default.
• W1927788271 cites W2110918734 @default.
• W1927788271 cites W2112792209 @default.
• W1927788271 cites W2115494923 @default.
• W1927788271 cites W2115722741 @default.
• W1927788271 cites W2124675599 @default.
• W1927788271 cites W2125805216 @default.
• W1927788271 cites W2131047041 @default.
• W1927788271 cites W2135498007 @default.
• W1927788271 cites W2144587135 @default.
• W1927788271 cites W2146316688 @default.
• W1927788271 cites W2147310171 @default.
• W1927788271 cites W2147347711 @default.
• W1927788271 cites W2149591661 @default.
• W1927788271 cites W2158217645 @default.
• W1927788271 cites W2159474448 @default.
• W1927788271 cites W2160460552 @default.
• W1927788271 cites W2165557965 @default.
• W1927788271 cites W2167047846 @default.
• W1927788271 cites W2168130410 @default.
• W1927788271 cites W2168553061 @default.
• W1927788271 cites W2170551349 @default.
• W1927788271 cites W2615479722 @default.
• W1927788271 cites W3143527962 @default.
• W1927788271 cites W3145943915 @default.
• W1927788271 cites W3150015993 @default.
• W1927788271 cites W595698770 @default.
• W1927788271 cites W1977961740 @default.
• W1927788271 doi "https://doi.org/10.1523/jneurosci.1001-15.2015" @default.

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