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- W1927881520 abstract "IntroductionPhosphatases are redox regulated and play important roles in inflammatory signaling. Protein phosphatase 2A (PP2A) activity can be modified by reactive oxygen species (ROS) produced by numerous stimuli, including cigarette smoke (CS).Aims and objectivesWe examined whether the alteration of an anti-oxidant, glutathione peroxidase-1 (GPx-1), in mice could affect phosphatase response against CS and impact on CS-induced emphysema.MethodsWild-type, GPx-1 overexpressing and knockout mice were exposed to short and long term cigarette smoke. Inflammatory responses and phosphatase activities were determined from lung tissue.ResultsOver-expression of GPx-1 protected CS-induced inflammation and airway enlargement. Knockdown of GPx-1 resulted in an exaggerated emphysema phenotype, correlating with low PP2A activity levels. Induction of PP2A activity coincided with increased protein tyrosine phosphatase 1B (PTP1B) activity and subsequent tyrosine dephosphorylation of the catalytic subunit of PP2A (Tyr307).ConclusionsTherefore, PP2A is redox regulated by GPx-1 and contributes to the inflammatory and proteolytic responses that occur in CS driven diseases. Targeting the PP2A pathway may be effective means of treating COPD and other diseases where inflammation plays a central role." @default.
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- W1927881520 date "2012-09-01" @default.
- W1927881520 modified "2023-10-17" @default.
- W1927881520 title "Anti-oxidants modulate protein phosphatase 2A (PP2A) activity to counteract cigarette smoke generated reactive oxygen species" @default.
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