Matches in SemOpenAlex for { <https://semopenalex.org/work/W1927888914> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1927888914 endingPage "E214" @default.
- W1927888914 startingPage "E208" @default.
- W1927888914 abstract "The kidney is a major site for insulin metabolism, but the enzymes involved and the products generated have not been established. To examine the products, we have perfused rat kidneys with insulin specifically iodinated on either the A14 or the B26 tyrosine. Labeled material from both the perfusate and kidney extract was examined by Sephadex G50 and high-performance liquid chromatography (HPLC). In perfusate from a filtering kidney, 22% of the insulin-sized material was not intact insulin on HPLC. With the nonfiltering kidney, 10.6% was not intact insulin. Labeled material from HPLC was sulfitolyzed and reinjected on HPLC. By use of 125I-iodo(A14)-insulin, almost all the degradation products contained an intact A-chain. By use of 125I-iodo(B26)-insulin, several different B-chain-cleaved products were obtained. The material extracted from the perfused kidney was different from perfusate products but similar to intracellular products from hepatocytes, suggesting that cellular metabolism by kidney and liver are similar. The major intracellular product had characteristics consistent with a cleavage between the B16 and B17 amino acids. This product and several of the perfusate products are also produced by insulin protease suggesting that this enzyme is involved in the degradation of insulin by kidney." @default.
- W1927888914 created "2016-06-24" @default.
- W1927888914 creator A5000877491 @default.
- W1927888914 creator A5014991683 @default.
- W1927888914 creator A5015533364 @default.
- W1927888914 creator A5027928287 @default.
- W1927888914 creator A5052832946 @default.
- W1927888914 creator A5073130137 @default.
- W1927888914 date "1989-02-01" @default.
- W1927888914 modified "2023-09-26" @default.
- W1927888914 title "Insulin degradation products from perfused rat kidney" @default.
- W1927888914 cites W1488062553 @default.
- W1927888914 cites W1992987367 @default.
- W1927888914 cites W1994305840 @default.
- W1927888914 cites W2001617128 @default.
- W1927888914 cites W2004127091 @default.
- W1927888914 cites W2010717302 @default.
- W1927888914 cites W2054165814 @default.
- W1927888914 cites W2061351888 @default.
- W1927888914 cites W2070321673 @default.
- W1927888914 cites W2077154346 @default.
- W1927888914 cites W2080199877 @default.
- W1927888914 cites W2114774294 @default.
- W1927888914 cites W2115843118 @default.
- W1927888914 cites W2127741280 @default.
- W1927888914 cites W2129694420 @default.
- W1927888914 cites W2143427122 @default.
- W1927888914 cites W2149938812 @default.
- W1927888914 cites W2158302952 @default.
- W1927888914 cites W2171182664 @default.
- W1927888914 cites W2171577805 @default.
- W1927888914 cites W2339343999 @default.
- W1927888914 cites W2400628044 @default.
- W1927888914 doi "https://doi.org/10.1152/ajpendo.1989.256.2.e208" @default.
- W1927888914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2645781" @default.
- W1927888914 hasPublicationYear "1989" @default.
- W1927888914 type Work @default.
- W1927888914 sameAs 1927888914 @default.
- W1927888914 citedByCount "7" @default.
- W1927888914 crossrefType "journal-article" @default.
- W1927888914 hasAuthorship W1927888914A5000877491 @default.
- W1927888914 hasAuthorship W1927888914A5014991683 @default.
- W1927888914 hasAuthorship W1927888914A5015533364 @default.
- W1927888914 hasAuthorship W1927888914A5027928287 @default.
- W1927888914 hasAuthorship W1927888914A5052832946 @default.
- W1927888914 hasAuthorship W1927888914A5073130137 @default.
- W1927888914 hasConcept C126322002 @default.
- W1927888914 hasConcept C134018914 @default.
- W1927888914 hasConcept C163994747 @default.
- W1927888914 hasConcept C179998833 @default.
- W1927888914 hasConcept C181199279 @default.
- W1927888914 hasConcept C185592680 @default.
- W1927888914 hasConcept C2779306644 @default.
- W1927888914 hasConcept C2780091579 @default.
- W1927888914 hasConcept C2780331951 @default.
- W1927888914 hasConcept C43617362 @default.
- W1927888914 hasConcept C55493867 @default.
- W1927888914 hasConcept C62231903 @default.
- W1927888914 hasConcept C71924100 @default.
- W1927888914 hasConcept C79879829 @default.
- W1927888914 hasConcept C86803240 @default.
- W1927888914 hasConceptScore W1927888914C126322002 @default.
- W1927888914 hasConceptScore W1927888914C134018914 @default.
- W1927888914 hasConceptScore W1927888914C163994747 @default.
- W1927888914 hasConceptScore W1927888914C179998833 @default.
- W1927888914 hasConceptScore W1927888914C181199279 @default.
- W1927888914 hasConceptScore W1927888914C185592680 @default.
- W1927888914 hasConceptScore W1927888914C2779306644 @default.
- W1927888914 hasConceptScore W1927888914C2780091579 @default.
- W1927888914 hasConceptScore W1927888914C2780331951 @default.
- W1927888914 hasConceptScore W1927888914C43617362 @default.
- W1927888914 hasConceptScore W1927888914C55493867 @default.
- W1927888914 hasConceptScore W1927888914C62231903 @default.
- W1927888914 hasConceptScore W1927888914C71924100 @default.
- W1927888914 hasConceptScore W1927888914C79879829 @default.
- W1927888914 hasConceptScore W1927888914C86803240 @default.
- W1927888914 hasIssue "2" @default.
- W1927888914 hasLocation W19278889141 @default.
- W1927888914 hasLocation W19278889142 @default.
- W1927888914 hasOpenAccess W1927888914 @default.
- W1927888914 hasPrimaryLocation W19278889141 @default.
- W1927888914 hasRelatedWork W1927888914 @default.
- W1927888914 hasRelatedWork W1983641721 @default.
- W1927888914 hasRelatedWork W2026226896 @default.
- W1927888914 hasRelatedWork W2053546036 @default.
- W1927888914 hasRelatedWork W2062360406 @default.
- W1927888914 hasRelatedWork W2066345847 @default.
- W1927888914 hasRelatedWork W2089387278 @default.
- W1927888914 hasRelatedWork W2095179743 @default.
- W1927888914 hasRelatedWork W2096423991 @default.
- W1927888914 hasRelatedWork W3144611280 @default.
- W1927888914 hasVolume "256" @default.
- W1927888914 isParatext "false" @default.
- W1927888914 isRetracted "false" @default.
- W1927888914 magId "1927888914" @default.
- W1927888914 workType "article" @default.