Matches in SemOpenAlex for { <https://semopenalex.org/work/W1928006063> ?p ?o ?g. }
- W1928006063 endingPage "33" @default.
- W1928006063 startingPage "24" @default.
- W1928006063 abstract "The present article overviews the role of bisphosphonates for the treatment and prevention of bone metastases and their antiangiogenic effects and antitumoral activity. The skeleton is a frequent and clinically relevant site of metastasis in cancer patients. The major events related to bone metastases include bone pain, bone loss, hypercalcemia, spinal cord compression, and fractures. On the basis of their radiographic features, bone metastases are classified as osteoblastic, osteoclastic, or mixed. The primary goals of treatment of bone metastases are reduction of the risk of pathological fractures and other skeletal-related events, and pain control. Bisphosphonates are used to prevent pathological fractures by inhibition of osteoclasts. Recent studies suggest that bisphosphonates have some direct antitumoral activity, mainly mediated through the blockade of angiogenic pathways. Further clinical studies are needed to determine the optimal treatment duration, timing and schedule of bisphosphonates, assess their role as adjuvant therapy for the prevention of bone metastases, and establish their antiangiogenic activity in association with standard cytotoxic and hormonal drugs for treatment of patients with advanced disease." @default.
- W1928006063 created "2016-06-24" @default.
- W1928006063 creator A5001899541 @default.
- W1928006063 creator A5021073341 @default.
- W1928006063 creator A5074801254 @default.
- W1928006063 creator A5077208943 @default.
- W1928006063 date "2007-01-01" @default.
- W1928006063 modified "2023-10-14" @default.
- W1928006063 title "Clinical usefulness of bisphosphonates in oncology: treatment of bone metastases, antitumoral activity and effect on bone resorption markers" @default.
- W1928006063 cites W129131919 @default.
- W1928006063 cites W1532955823 @default.
- W1928006063 cites W1768011742 @default.
- W1928006063 cites W1867790738 @default.
- W1928006063 cites W1875067624 @default.
- W1928006063 cites W1880057253 @default.
- W1928006063 cites W1900951750 @default.
- W1928006063 cites W1954585625 @default.
- W1928006063 cites W1967875617 @default.
- W1928006063 cites W1974568982 @default.
- W1928006063 cites W1977202592 @default.
- W1928006063 cites W1989014251 @default.
- W1928006063 cites W1991668450 @default.
- W1928006063 cites W1996589664 @default.
- W1928006063 cites W2000144084 @default.
- W1928006063 cites W2005398724 @default.
- W1928006063 cites W2027735110 @default.
- W1928006063 cites W2035331993 @default.
- W1928006063 cites W2037542472 @default.
- W1928006063 cites W2049748946 @default.
- W1928006063 cites W2055038372 @default.
- W1928006063 cites W2056647289 @default.
- W1928006063 cites W2060736857 @default.
- W1928006063 cites W2074890088 @default.
- W1928006063 cites W2088500774 @default.
- W1928006063 cites W2093164779 @default.
- W1928006063 cites W2101397164 @default.
- W1928006063 cites W2103314990 @default.
- W1928006063 cites W2104298626 @default.
- W1928006063 cites W2104923745 @default.
- W1928006063 cites W2107208293 @default.
- W1928006063 cites W2110338458 @default.
- W1928006063 cites W2115871403 @default.
- W1928006063 cites W2115962082 @default.
- W1928006063 cites W2126048792 @default.
- W1928006063 cites W2136112016 @default.
- W1928006063 cites W2137083298 @default.
- W1928006063 cites W2140216617 @default.
- W1928006063 cites W2142234592 @default.
- W1928006063 cites W2142421083 @default.
- W1928006063 cites W2144287001 @default.
- W1928006063 cites W2144860907 @default.
- W1928006063 cites W2149876087 @default.
- W1928006063 cites W2152188947 @default.
- W1928006063 cites W2158787920 @default.
- W1928006063 cites W2162827359 @default.
- W1928006063 cites W2166707293 @default.
- W1928006063 cites W2184505089 @default.
- W1928006063 cites W2408306201 @default.
- W1928006063 cites W565115277 @default.
- W1928006063 doi "https://doi.org/10.5301/jbm.2008.1514" @default.
- W1928006063 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28207153" @default.
- W1928006063 hasPublicationYear "2007" @default.
- W1928006063 type Work @default.
- W1928006063 sameAs 1928006063 @default.
- W1928006063 citedByCount "14" @default.
- W1928006063 countsByYear W19280060632012 @default.
- W1928006063 countsByYear W19280060632013 @default.
- W1928006063 countsByYear W19280060632014 @default.
- W1928006063 countsByYear W19280060632015 @default.
- W1928006063 countsByYear W19280060632016 @default.
- W1928006063 countsByYear W19280060632019 @default.
- W1928006063 crossrefType "journal-article" @default.
- W1928006063 hasAuthorship W1928006063A5001899541 @default.
- W1928006063 hasAuthorship W1928006063A5021073341 @default.
- W1928006063 hasAuthorship W1928006063A5074801254 @default.
- W1928006063 hasAuthorship W1928006063A5077208943 @default.
- W1928006063 hasConcept C118552586 @default.
- W1928006063 hasConcept C121608353 @default.
- W1928006063 hasConcept C126322002 @default.
- W1928006063 hasConcept C143998085 @default.
- W1928006063 hasConcept C170033053 @default.
- W1928006063 hasConcept C2776139714 @default.
- W1928006063 hasConcept C2776169692 @default.
- W1928006063 hasConcept C2776286101 @default.
- W1928006063 hasConcept C2776541429 @default.
- W1928006063 hasConcept C2777251235 @default.
- W1928006063 hasConcept C2777783956 @default.
- W1928006063 hasConcept C2778231337 @default.
- W1928006063 hasConcept C2779013556 @default.
- W1928006063 hasConcept C2780775167 @default.
- W1928006063 hasConcept C673006 @default.
- W1928006063 hasConcept C71924100 @default.
- W1928006063 hasConceptScore W1928006063C118552586 @default.
- W1928006063 hasConceptScore W1928006063C121608353 @default.
- W1928006063 hasConceptScore W1928006063C126322002 @default.
- W1928006063 hasConceptScore W1928006063C143998085 @default.
- W1928006063 hasConceptScore W1928006063C170033053 @default.
- W1928006063 hasConceptScore W1928006063C2776139714 @default.