FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1928285801> ?p ?o ?g. }

• W1928285801 abstract "Background Around 16% of adults have symptoms of overactive bladder (urgency with frequency and/or urge incontinence). The prevalence increases with age. Anticholinergic drugs are commonly used to treat this condition. Objectives To determine the effects of anticholinergic drugs for the treatment of overactive bladder syndrome. Search methods We searched the Cochrane Incontinence Group Specialised Trials Register (searched 14 June 2005) and the reference lists of relevant articles. Selection criteria Randomised or quasi‐randomised trials in adults with overactive bladder syndrome that compared an anticholinergic drug with placebo treatment or no treatment. Data collection and analysis Two reviewer authors independently assessed eligibility, trial quality and extracted data. Data were processed as described in the Cochrane Handbook for Systematic Reviews of Interventions (Higgins 2005). Main results Sixty ‐one trials, 42 with parallel‐group designs and 19 crossover trials were included (11,956 adults). Most trials were described as double‐blind but were variable in other aspects of quality. The crossover trials did not present data in a way that allowed inclusion in the meta‐analysis. Nine medications were tested: darifenacin; emepronium bromide or carrageenate; oxybutynin; propiverine; propantheline; tolterodine; trospium chloride; and solifenacin. One trial included the newer, slow release formulation of tolterodine. At the end of the treatment period, cure or improvement (relative risk (RR) 1.39, 95%CI 1.28 to 1.51), difference in leakage episodes in 24 hours (weighted mean difference (WMD) ‐0.54; 95% CI ‐0.67 to ‐0.41) and difference in number of voids in 24 hours (WMD ‐0.69; 95%CI ‐0.84 to ‐0.54) were statistically significant favouring medication. Statistically significant but modest sized improvements in quality of life scores were reported in recently completed trials. There was three times the rate of dry mouth in the medication group (RR 3.00 95% CI 2.70 to 3.34) but no statistically significant difference in withdrawal (RR 1.11, 95% CI 0.91 to 1.36). Sensitivity analysis, while limited by small numbers of trials, showed little likelihood that the effects were modified by age, sex, diagnosis, or choice of drug. Authors' conclusions The use of anticholinergic drugs by people with overactive bladder syndrome results in statistically significant improvements in symptoms. Recent trials suggest that this is associated with modest improvement in quality of life. Dry mouth is a common side effect of therapy but did not seem to have an effect on the numbers of withdrawals. It is not clear whether any benefits are sustained during long‐term treatment or after treatment stops." @default.
• W1928285801 created "2016-06-24" @default.
• W1928285801 creator A5019099439 @default.
• W1928285801 creator A5032035046 @default.
• W1928285801 creator A5052631604 @default.
• W1928285801 creator A5070996561 @default.
• W1928285801 creator A5072409397 @default.
• W1928285801 date "2006-10-18" @default.
• W1928285801 modified "2023-10-14" @default.
• W1928285801 title "Anticholinergic drugs versus placebo for overactive bladder syndrome in adults" @default.
• W1928285801 cites W138736198 @default.
• W1928285801 cites W1410775549 @default.
• W1928285801 cites W1484199029 @default.
• W1928285801 cites W1562810967 @default.
• W1928285801 cites W180920641 @default.
• W1928285801 cites W1821426726 @default.
• W1928285801 cites W1955636074 @default.
• W1928285801 cites W1965460248 @default.
• W1928285801 cites W1967031158 @default.
• W1928285801 cites W1967312126 @default.
• W1928285801 cites W1970924708 @default.
• W1928285801 cites W1972586046 @default.
• W1928285801 cites W1973445202 @default.
• W1928285801 cites W1974682518 @default.
• W1928285801 cites W1975761784 @default.
• W1928285801 cites W1977586210 @default.
• W1928285801 cites W1980051351 @default.
• W1928285801 cites W1982589773 @default.
• W1928285801 cites W1983192993 @default.
• W1928285801 cites W1986053715 @default.
• W1928285801 cites W1986143238 @default.
• W1928285801 cites W1986761450 @default.
• W1928285801 cites W1993486897 @default.
• W1928285801 cites W1996684801 @default.
• W1928285801 cites W1998270091 @default.
• W1928285801 cites W2002881201 @default.
• W1928285801 cites W2005791359 @default.
• W1928285801 cites W2006171475 @default.
• W1928285801 cites W2008079238 @default.
• W1928285801 cites W2010507209 @default.
• W1928285801 cites W2012563222 @default.
• W1928285801 cites W2015584710 @default.
• W1928285801 cites W2016515396 @default.
• W1928285801 cites W2021702941 @default.
• W1928285801 cites W2024975356 @default.
• W1928285801 cites W2026599479 @default.
• W1928285801 cites W2028811068 @default.
• W1928285801 cites W2030219440 @default.
• W1928285801 cites W2031410459 @default.
• W1928285801 cites W2032844735 @default.
• W1928285801 cites W2033133691 @default.
• W1928285801 cites W2034782018 @default.
• W1928285801 cites W2036285158 @default.
• W1928285801 cites W2039605715 @default.
• W1928285801 cites W2039891090 @default.
• W1928285801 cites W2040288000 @default.
• W1928285801 cites W2040644012 @default.
• W1928285801 cites W2041010331 @default.
• W1928285801 cites W2043170136 @default.
• W1928285801 cites W2043721744 @default.
• W1928285801 cites W2043742417 @default.
• W1928285801 cites W2044322882 @default.
• W1928285801 cites W2044943786 @default.
• W1928285801 cites W2049491657 @default.
• W1928285801 cites W2058954362 @default.
• W1928285801 cites W2060522553 @default.
• W1928285801 cites W2061757654 @default.
• W1928285801 cites W2063768742 @default.
• W1928285801 cites W2068710144 @default.
• W1928285801 cites W207032901 @default.
• W1928285801 cites W2072187682 @default.
• W1928285801 cites W2081405720 @default.
• W1928285801 cites W2083510953 @default.
• W1928285801 cites W2087498132 @default.
• W1928285801 cites W2088419730 @default.
• W1928285801 cites W2088679190 @default.
• W1928285801 cites W2092749677 @default.
• W1928285801 cites W2094952568 @default.
• W1928285801 cites W2109298103 @default.
• W1928285801 cites W2121173491 @default.
• W1928285801 cites W2121811192 @default.
• W1928285801 cites W2127252378 @default.
• W1928285801 cites W2127955638 @default.
• W1928285801 cites W2129450531 @default.
• W1928285801 cites W2134928141 @default.
• W1928285801 cites W2136398611 @default.
• W1928285801 cites W2136548062 @default.
• W1928285801 cites W2137775206 @default.
• W1928285801 cites W2140008227 @default.
• W1928285801 cites W2141823090 @default.
• W1928285801 cites W2147668516 @default.
• W1928285801 cites W2152791010 @default.
• W1928285801 cites W2153390278 @default.
• W1928285801 cites W2158321390 @default.
• W1928285801 cites W2160887104 @default.
• W1928285801 cites W2169544570 @default.
• W1928285801 cites W2171354081 @default.
• W1928285801 cites W2171846085 @default.
• W1928285801 cites W2330911951 @default.
• W1928285801 cites W2339866418 @default.

• next