FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1928327895> ?p ?o ?g. }

• W1928327895 endingPage "488" @default.
• W1928327895 startingPage "482" @default.
• W1928327895 abstract "Estrogen-replacement therapy is important for the prevention of postmenopausal osteoporosis. However, oral synthetic and conjugated estrogens increase biliary cholesterol saturation index and risk of gallstone disease. To examine whether transdermal estrogen administration could avoid these adverse effects, 17 postmenopausal women were treated with transdermal estradiol (Estraderm TTS; Ciba-Geigy, Arnhem, The Netherlands), 100 micrograms/day for 4 weeks, and after 1 month without therapy, with oral estradiol (Progynova; Schering, Weesp, The Netherlands), 2 mg/day for 4 weeks. The increase in the serum estradiol level was much higher during transdermal than oral estradiol administration. On the contrary, the increase in the serum estrone level was much more pronounced during oral treatment. Both modes of treatment led to a similar reduction of urinary calcium excretion. A highly significant decrease in serum phosphate levels was found during transdermal therapy. Biliary cholesterol saturation index did not change during transdermal therapy (mean +/- SEM, 1.25 +/- 0.06 before and 1.22 +/- 0.07 at the end of transdermal therapy; P = NS). A slight increase in cholesterol saturation index that did not reach statistical significance was found during oral therapy (1.28 +/- 0.09 before and 1.36 +/- 0.09 during oral treatment). However, the subgroup of women with strong increases in serum estrone levels during oral estradiol therapy (greater than 0.5 pmol/mL; n = 8) generally had increased biliary cholesterol saturation index, a decrease in relative percentage chenodeoxycholic acid in bile, and increased serum sex hormone-binding globulin levels during oral treatment. Cholesterol monohydrate crystals were never found in duodenal biles during either treatment. This study indicates that transdermal estradiol does not induce lithogenic bile. On the contrary, oral estradiol leads to lithogenic bile in a subgroup of women with strong increases in serum estrone levels during oral treatment." @default.
• W1928327895 created "2016-06-24" @default.
• W1928327895 creator A5022574892 @default.
• W1928327895 creator A5045668995 @default.
• W1928327895 creator A5054697454 @default.
• W1928327895 creator A5079547028 @default.
• W1928327895 creator A5083281668 @default.
• W1928327895 date "1991-02-01" @default.
• W1928327895 modified "2023-09-26" @default.
• W1928327895 title "Different hepatobiliary effects of oral and transdermal estradiol in postmenopausal women" @default.
• W1928327895 cites W111127352 @default.
• W1928327895 cites W1561293749 @default.
• W1928327895 cites W1785735331 @default.
• W1928327895 cites W1831991634 @default.
• W1928327895 cites W1895325632 @default.
• W1928327895 cites W1978092733 @default.
• W1928327895 cites W1992063947 @default.
• W1928327895 cites W2009924670 @default.
• W1928327895 cites W2020889463 @default.
• W1928327895 cites W2032255486 @default.
• W1928327895 cites W2046413299 @default.
• W1928327895 cites W2047366838 @default.
• W1928327895 cites W2052774670 @default.
• W1928327895 cites W2064066142 @default.
• W1928327895 cites W2066315702 @default.
• W1928327895 cites W2071836605 @default.
• W1928327895 cites W2074581657 @default.
• W1928327895 cites W2080775538 @default.
• W1928327895 cites W2110011367 @default.
• W1928327895 cites W2115932658 @default.
• W1928327895 cites W2118890497 @default.
• W1928327895 cites W2129649182 @default.
• W1928327895 cites W2145077323 @default.
• W1928327895 cites W2324161744 @default.
• W1928327895 cites W2412039171 @default.
• W1928327895 cites W2413000267 @default.
• W1928327895 cites W2469170149 @default.
• W1928327895 cites W3022017015 @default.
• W1928327895 cites W4232136535 @default.
• W1928327895 cites W4376522634 @default.
• W1928327895 doi "https://doi.org/10.1016/0016-5085(91)90220-f" @default.
• W1928327895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1898652" @default.
• W1928327895 hasPublicationYear "1991" @default.
• W1928327895 type Work @default.
• W1928327895 sameAs 1928327895 @default.
• W1928327895 citedByCount "61" @default.
• W1928327895 countsByYear W19283278952013 @default.
• W1928327895 countsByYear W19283278952014 @default.
• W1928327895 countsByYear W19283278952020 @default.
• W1928327895 crossrefType "journal-article" @default.
• W1928327895 hasAuthorship W1928327895A5022574892 @default.
• W1928327895 hasAuthorship W1928327895A5045668995 @default.
• W1928327895 hasAuthorship W1928327895A5054697454 @default.
• W1928327895 hasAuthorship W1928327895A5079547028 @default.
• W1928327895 hasAuthorship W1928327895A5083281668 @default.
• W1928327895 hasConcept C126322002 @default.
• W1928327895 hasConcept C134018914 @default.
• W1928327895 hasConcept C197934379 @default.
• W1928327895 hasConcept C205679159 @default.
• W1928327895 hasConcept C2777056448 @default.
• W1928327895 hasConcept C2777164284 @default.
• W1928327895 hasConcept C2778163477 @default.
• W1928327895 hasConcept C2778656385 @default.
• W1928327895 hasConcept C2779279991 @default.
• W1928327895 hasConcept C2780159708 @default.
• W1928327895 hasConcept C3020687571 @default.
• W1928327895 hasConcept C71924100 @default.
• W1928327895 hasConcept C98274493 @default.
• W1928327895 hasConceptScore W1928327895C126322002 @default.
• W1928327895 hasConceptScore W1928327895C134018914 @default.
• W1928327895 hasConceptScore W1928327895C197934379 @default.
• W1928327895 hasConceptScore W1928327895C205679159 @default.
• W1928327895 hasConceptScore W1928327895C2777056448 @default.
• W1928327895 hasConceptScore W1928327895C2777164284 @default.
• W1928327895 hasConceptScore W1928327895C2778163477 @default.
• W1928327895 hasConceptScore W1928327895C2778656385 @default.
• W1928327895 hasConceptScore W1928327895C2779279991 @default.
• W1928327895 hasConceptScore W1928327895C2780159708 @default.
• W1928327895 hasConceptScore W1928327895C3020687571 @default.
• W1928327895 hasConceptScore W1928327895C71924100 @default.
• W1928327895 hasConceptScore W1928327895C98274493 @default.
• W1928327895 hasIssue "2" @default.
• W1928327895 hasLocation W19283278951 @default.
• W1928327895 hasLocation W19283278952 @default.
• W1928327895 hasOpenAccess W1928327895 @default.
• W1928327895 hasPrimaryLocation W19283278951 @default.
• W1928327895 hasRelatedWork W1973650914 @default.
• W1928327895 hasRelatedWork W2006912241 @default.
• W1928327895 hasRelatedWork W2038131003 @default.
• W1928327895 hasRelatedWork W2272170328 @default.
• W1928327895 hasRelatedWork W2315280756 @default.
• W1928327895 hasRelatedWork W2398766317 @default.
• W1928327895 hasRelatedWork W2416044200 @default.
• W1928327895 hasRelatedWork W2463785292 @default.
• W1928327895 hasRelatedWork W4224694746 @default.
• W1928327895 hasRelatedWork W4254016327 @default.
• W1928327895 hasVolume "100" @default.
• W1928327895 isParatext "false" @default.

• next