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- W1928456787 abstract "In confirmation of the work of others L-3,4-dihydroxyphenylalanine (dopa) increases the blood pressure when injected intravenously, due to its decarboxylation to dopamine by dopa decarboxylase in vivo. This pressor response is prevented by prior injection of a dopa decarboxylase inhibitor, 5-(3-hydroxycinnamoyl) salicylic acid (HCS). The dopamine formed and excreted in the urine has been isolated and identified, and the amount formed is decreased by HCS.m -Tyrosine also increases the blood pressure, due to the decarboxylated product m -tyramine, which was isolated from the urine. This decarboxylation also is blocked by HCS, as reflected by a decreased pressor response and excretion of m -tyramine. The chief metabolic products of m -tyrosine in the cat are m-hydroxyphenylacetic acid and m -hydroxyphenylaceturic acid.m -Hydroxyphenylpyruvic and 3,4-dihydroxyphenylpyruvic acids increase the blood pressure of cats and rats when administered intravenously. It is shown that this is due to transaminiation to time corresponding amino acids, m -tyrosine and dopa, respectively, and their subsequent decarboxylation to m -tyramine and dopamine respectively. The m -tyrosine and m -tyramine have been isolated from the urine and identified.HCS decreases the amount of m -tyramine formed from m -hydroxyphenylpyruvic acid.m -Hydroxyphenylpyruvic acid administration in cats also leads to the urinary excretion of m -hydroxyphenylacetic acid and m -hydroxyphenyllactic acid.Pyridoxine deficiency decreases kidney and liver dopa decarboxylase apoenzyme and coenzyme, with a greater effect on liver apoenzyme. This is reflected in a decreased blood pressure response to dopa and 3,4-dihydroxyphenylpyruvic acid.p -Hydroxyphenylpyruvic acid, DL-phenylalanine and L-tyrosine have no pressor effects, and no urinary tyramine or phenylethylamine can be detected after the administration of the latter two compounds to cats and rats pretreated with iproniazid." @default.
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- W1928456787 date "1961-03-01" @default.
- W1928456787 modified "2023-09-23" @default.
- W1928456787 title "Metabolism of 3-hydroxy- and 3,4-dihydroxyphenylpyruvic acids in vivo." @default.
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