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• W1928488802 abstract "In the literature, the introduction of fluorine into bioactive molecules has been known to enhance the biological activity relative to the parent molecule. Described in this article is the synthesis of 4R-fluoro-L-NIL (12) and 4,4-difluoro-L-NIL (23) as part of our iNOS program. Both 12 and 23 were found to be selective iNOS inhibitors as shown in Table 2 below. Secondarily, methodology to synthesize orthogonally protected 4-fluoro-L-lysine and 4,4-difluoro-L-lysine has been developed." @default.
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• W1928488802 date "2003-01-01" @default.
• W1928488802 modified "2023-09-27" @default.
• W1928488802 title "4-Fluorinated<scp>l</scp>-lysine analogs as selective i-NOS inhibitors: methodology for introducing fluorine into the lysine side chain" @default.
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• W1928488802 doi "https://doi.org/10.1039/b307563j" @default.
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