Matches in SemOpenAlex for { <https://semopenalex.org/work/W1928498639> ?p ?o ?g. }
- W1928498639 endingPage "3168" @default.
- W1928498639 startingPage "3161" @default.
- W1928498639 abstract "The bipotential Ganglion Mother Cells, or GMCs, in the DrosophilaCNS asymmetrically divide to generate two distinct post-mitotic neurons. Here,we show that the midline repellent Slit (Sli), via its receptor Roundabout(Robo), promotes the terminal asymmetric division of GMCs. In GMC-1 of the RP2/sib lineage, Slit promotes asymmetric division by down regulating two POU proteins, Nubbin and Mitimere. The down regulation of these proteins allows the asymmetric localization of Inscuteable, leading to the asymmetric division of GMC-1. Consistent with this, over-expression of these POU genes in a late GMC-1 causes mis-localization of Insc and symmetric division of GMC-1 to generate two RP2s. Similarly, increasing the dosage of the two POU genes insli mutant background enhances the penetrance of the RP2 lineage defects whereas reducing the dosage of the two genes reduces the penetrance of the phenotype. These results tie a cell-non-autonomous signaling pathway to the asymmetric division of precursor cells during neurogenesis." @default.
- W1928498639 created "2016-06-24" @default.
- W1928498639 creator A5057079396 @default.
- W1928498639 creator A5070359400 @default.
- W1928498639 date "2001-08-15" @default.
- W1928498639 modified "2023-10-17" @default.
- W1928498639 title "Slit signaling promotes the terminal asymmetric division of neural precursor cells in the Drosophila CNS" @default.
- W1928498639 cites W1502837338 @default.
- W1928498639 cites W1629720407 @default.
- W1928498639 cites W1967450020 @default.
- W1928498639 cites W1983075472 @default.
- W1928498639 cites W1996775753 @default.
- W1928498639 cites W1998025071 @default.
- W1928498639 cites W2007696043 @default.
- W1928498639 cites W2010571954 @default.
- W1928498639 cites W2017133589 @default.
- W1928498639 cites W2021182179 @default.
- W1928498639 cites W2036355011 @default.
- W1928498639 cites W2036567100 @default.
- W1928498639 cites W2048228486 @default.
- W1928498639 cites W2048421851 @default.
- W1928498639 cites W2051656608 @default.
- W1928498639 cites W2061172411 @default.
- W1928498639 cites W2063751484 @default.
- W1928498639 cites W2079128745 @default.
- W1928498639 cites W2088658701 @default.
- W1928498639 cites W2089405081 @default.
- W1928498639 cites W2113519429 @default.
- W1928498639 cites W2117009558 @default.
- W1928498639 cites W2123254472 @default.
- W1928498639 cites W2155897862 @default.
- W1928498639 cites W2167324829 @default.
- W1928498639 cites W2167721895 @default.
- W1928498639 cites W2168344733 @default.
- W1928498639 doi "https://doi.org/10.1242/dev.128.16.3161" @default.
- W1928498639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11688564" @default.
- W1928498639 hasPublicationYear "2001" @default.
- W1928498639 type Work @default.
- W1928498639 sameAs 1928498639 @default.
- W1928498639 citedByCount "26" @default.
- W1928498639 countsByYear W19284986392012 @default.
- W1928498639 countsByYear W19284986392015 @default.
- W1928498639 countsByYear W19284986392019 @default.
- W1928498639 countsByYear W19284986392021 @default.
- W1928498639 countsByYear W19284986392022 @default.
- W1928498639 crossrefType "journal-article" @default.
- W1928498639 hasAuthorship W1928498639A5057079396 @default.
- W1928498639 hasAuthorship W1928498639A5070359400 @default.
- W1928498639 hasBestOaLocation W19284986391 @default.
- W1928498639 hasConcept C104317684 @default.
- W1928498639 hasConcept C109157449 @default.
- W1928498639 hasConcept C121587040 @default.
- W1928498639 hasConcept C127716648 @default.
- W1928498639 hasConcept C1491633281 @default.
- W1928498639 hasConcept C196287685 @default.
- W1928498639 hasConcept C199215989 @default.
- W1928498639 hasConcept C200544954 @default.
- W1928498639 hasConcept C2776746469 @default.
- W1928498639 hasConcept C2778977658 @default.
- W1928498639 hasConcept C2779530196 @default.
- W1928498639 hasConcept C54355233 @default.
- W1928498639 hasConcept C69125201 @default.
- W1928498639 hasConcept C85813293 @default.
- W1928498639 hasConcept C86339819 @default.
- W1928498639 hasConcept C86803240 @default.
- W1928498639 hasConcept C93304396 @default.
- W1928498639 hasConcept C95444343 @default.
- W1928498639 hasConceptScore W1928498639C104317684 @default.
- W1928498639 hasConceptScore W1928498639C109157449 @default.
- W1928498639 hasConceptScore W1928498639C121587040 @default.
- W1928498639 hasConceptScore W1928498639C127716648 @default.
- W1928498639 hasConceptScore W1928498639C1491633281 @default.
- W1928498639 hasConceptScore W1928498639C196287685 @default.
- W1928498639 hasConceptScore W1928498639C199215989 @default.
- W1928498639 hasConceptScore W1928498639C200544954 @default.
- W1928498639 hasConceptScore W1928498639C2776746469 @default.
- W1928498639 hasConceptScore W1928498639C2778977658 @default.
- W1928498639 hasConceptScore W1928498639C2779530196 @default.
- W1928498639 hasConceptScore W1928498639C54355233 @default.
- W1928498639 hasConceptScore W1928498639C69125201 @default.
- W1928498639 hasConceptScore W1928498639C85813293 @default.
- W1928498639 hasConceptScore W1928498639C86339819 @default.
- W1928498639 hasConceptScore W1928498639C86803240 @default.
- W1928498639 hasConceptScore W1928498639C93304396 @default.
- W1928498639 hasConceptScore W1928498639C95444343 @default.
- W1928498639 hasIssue "16" @default.
- W1928498639 hasLocation W19284986391 @default.
- W1928498639 hasLocation W19284986392 @default.
- W1928498639 hasOpenAccess W1928498639 @default.
- W1928498639 hasPrimaryLocation W19284986391 @default.
- W1928498639 hasRelatedWork W1928498639 @default.
- W1928498639 hasRelatedWork W1981084599 @default.
- W1928498639 hasRelatedWork W2038910970 @default.
- W1928498639 hasRelatedWork W2048047215 @default.
- W1928498639 hasRelatedWork W2059568022 @default.
- W1928498639 hasRelatedWork W2070110506 @default.
- W1928498639 hasRelatedWork W2076070951 @default.
- W1928498639 hasRelatedWork W2108539902 @default.