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- W1928730528 abstract "The function of the minor subset of T lymphocytes bearing the γδ T cell antigen receptor is uncertain. Although some γδ T cells react to microbial products, responsiveness has only rarely been demonstrated toward a bacterial antigen from a naturally occurring human infection. Synovial fluid lymphocytes from patients with Lyme arthritis contain a large proportion of γδ cells that proliferate in response to the causative spirochete, Borrelia burgdorferi. Furthermore, synovial γδ T cell clones express elevated and sustained levels of the ligand for Fas (APO-1, CD95) compared to αβ T cells, and induce apoptosis of Fashigh CD4+ synovial lymphocytes. The findings suggest that γδ T cells contribute to defense in human infections, as well as manifest an immunoregulatory function at inflammatory sites by a Fas-dependent process." @default.
- W1928730528 created "2016-06-24" @default.
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- W1928730528 date "1996-12-01" @default.
- W1928730528 modified "2023-09-24" @default.
- W1928730528 title "Apoptosis of Fashigh CD4+ Synovial T Cells by <i>Borrelia-</i>reactive Fas-ligandhigh γδ T Cells in Lyme Arthritis" @default.
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- W1928730528 doi "https://doi.org/10.1084/jem.184.6.2109" @default.
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