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- W192885275 endingPage "825" @default.
- W192885275 startingPage "785" @default.
- W192885275 abstract "In a disease, systemic lupus erythematosus (SLE), that afflicts children and young adults, flares without warning, and attacks multiple organ systems so indiscriminately, it seems particularly unjust that it also targets the brain—the core of reason, emotion, and the essence of self. Neuropsychiatric symptoms of SLE were first reported in 1872 by Kaposi, who described two lupus patients with delirium [1]. Depending on the diagnostic methodology utilized, neuropsychiatric manifestations have a prevalence of up to 75–90% [2–4]. They encompass a wide variety of conditions, ranging from stroke, seizures, headaches, neuropathy, transverse myelitis, and movement disorders, to cognitive deficits, depression, mania, anxiety, psychosis and delirium (acute confusional state). Central nervous system (CNS) involvement is a major cause of morbidity in SLE, and is second only to renal failure and accelerated atherosclerosis as a cause of mortality. The pathogenesis of neuropsychiatric syndromes in SLE is multifaceted and complex, including direct CNS involvement, secondary effects of infection (CNS and systemic). uremia, electrolyte disturbances, hypertension, and other systemic diseases, medication side effects, and psychological reactions to chronic illness. While neurologic disorders in SLE are discussed in Chapter 26, and cognitive impairment in Chapter 28, the present chapter focuses on psychiatric manifestations of SLE, including their prevalence, pathogenesis, classification, diagnosis, and treatment." @default.
- W192885275 created "2016-06-24" @default.
- W192885275 creator A5034686440 @default.
- W192885275 creator A5058749011 @default.
- W192885275 creator A5012833577 @default.
- W192885275 date "2004-01-01" @default.
- W192885275 modified "2023-09-27" @default.
- W192885275 title "PSYCHIATRIC ASPECTS OF SYSTEMIC LUPUS ERYTHEMATOSUS" @default.
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