FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1928905511> ?p ?o ?g. }

• W1928905511 endingPage "159" @default.
• W1928905511 startingPage "156" @default.
• W1928905511 abstract "Objective : To investigated the growth-inhibiting and apoptosis mediating effect of Plectranthus amboinicus (Lour.) Spreng ethyl acetate extract (PAE) in combination therapy with doxorubicin against T47D cell lines, to analyzed the expression of cyclin D1 and COX-2 (cyclooxigenase-2) proteins. Methods: The assays were performed in the study were cytotoxicity assay, cell cycle assay, apoptosis induction, and immunocytochemistry of T47D cells. The cytotoxicity effects were determined by using MTT [3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyl tetrazolium bromide] assay. The effect on modulation of cell cycle and apoptosis was observed by flow cytometry assay in both single dose of PAE and its combination with doxorubicin. The expression of cyclin D1 and COX-2 proteins on T47D cell lines was identified by using immunocytochemistry. Results: The result showed that the PAE 8 µg/ml had the synergistic effect with doxorubicin against T47D cells based on Combination Index analysis. The PAE induced apoptosis and cell accumulation at G1 phase. The combination of PAE 8 µg/ml with doxorubicin 1 µg/ml caused apoptosis induction same with its single treatment, but there was increasing in cell accumulation at G1 phase. Expression of cyclin D1 indicated that both single application and combination of PAE with doxorubicin could arrest the cell cycle of T47D cells. The expression of COX-2 showed that the combination could inhibit the metastasis of T47D breast cancer cells. Conclusion : Based on the result that PAE could be a potential co-chemoterapeutic agent with doxorubicin on breast cancer cells." @default.
• W1928905511 created "2016-06-24" @default.
• W1928905511 creator A5013971147 @default.
• W1928905511 creator A5046894961 @default.
• W1928905511 creator A5051138296 @default.
• W1928905511 date "2015-08-14" @default.
• W1928905511 modified "2023-09-23" @default.
• W1928905511 title "COMBINATION EFFECT OF ETHYLACETATE EXTRACTS OF PLECTRANTHUS AMBOINICUS (LOUR.) SPRENG. WITH DOXORUBICIN AGAINTS T47D BREAST CANCER CELLS" @default.
• W1928905511 cites W2100128089 @default.
• W1928905511 cites W2131712191 @default.
• W1928905511 cites W2157403273 @default.
• W1928905511 cites W2183784384 @default.
• W1928905511 cites W2186274580 @default.
• W1928905511 cites W2396509159 @default.
• W1928905511 cites W2783624685 @default.
• W1928905511 cites W2948428968 @default.
• W1928905511 cites W3197002323 @default.
• W1928905511 cites W611041259 @default.
• W1928905511 cites W1529385150 @default.
• W1928905511 hasPublicationYear "2015" @default.
• W1928905511 type Work @default.
• W1928905511 sameAs 1928905511 @default.
• W1928905511 citedByCount "4" @default.
• W1928905511 countsByYear W19289055112016 @default.
• W1928905511 countsByYear W19289055112017 @default.
• W1928905511 countsByYear W19289055112018 @default.
• W1928905511 countsByYear W19289055112021 @default.
• W1928905511 crossrefType "journal-article" @default.
• W1928905511 hasAuthorship W1928905511A5013971147 @default.
• W1928905511 hasAuthorship W1928905511A5046894961 @default.
• W1928905511 hasAuthorship W1928905511A5051138296 @default.
• W1928905511 hasConcept C105696609 @default.
• W1928905511 hasConcept C109316439 @default.
• W1928905511 hasConcept C121608353 @default.
• W1928905511 hasConcept C126322002 @default.
• W1928905511 hasConcept C134018914 @default.
• W1928905511 hasConcept C153911025 @default.
• W1928905511 hasConcept C185592680 @default.
• W1928905511 hasConcept C190283241 @default.
• W1928905511 hasConcept C199835354 @default.
• W1928905511 hasConcept C202751555 @default.
• W1928905511 hasConcept C2776694085 @default.
• W1928905511 hasConcept C2780783641 @default.
• W1928905511 hasConcept C2781303535 @default.
• W1928905511 hasConcept C29537977 @default.
• W1928905511 hasConcept C35866371 @default.
• W1928905511 hasConcept C55493867 @default.
• W1928905511 hasConcept C71924100 @default.
• W1928905511 hasConcept C86803240 @default.
• W1928905511 hasConcept C94561458 @default.
• W1928905511 hasConcept C96232424 @default.
• W1928905511 hasConcept C98274493 @default.
• W1928905511 hasConceptScore W1928905511C105696609 @default.
• W1928905511 hasConceptScore W1928905511C109316439 @default.
• W1928905511 hasConceptScore W1928905511C121608353 @default.
• W1928905511 hasConceptScore W1928905511C126322002 @default.
• W1928905511 hasConceptScore W1928905511C134018914 @default.
• W1928905511 hasConceptScore W1928905511C153911025 @default.
• W1928905511 hasConceptScore W1928905511C185592680 @default.
• W1928905511 hasConceptScore W1928905511C190283241 @default.
• W1928905511 hasConceptScore W1928905511C199835354 @default.
• W1928905511 hasConceptScore W1928905511C202751555 @default.
• W1928905511 hasConceptScore W1928905511C2776694085 @default.
• W1928905511 hasConceptScore W1928905511C2780783641 @default.
• W1928905511 hasConceptScore W1928905511C2781303535 @default.
• W1928905511 hasConceptScore W1928905511C29537977 @default.
• W1928905511 hasConceptScore W1928905511C35866371 @default.
• W1928905511 hasConceptScore W1928905511C55493867 @default.
• W1928905511 hasConceptScore W1928905511C71924100 @default.
• W1928905511 hasConceptScore W1928905511C86803240 @default.
• W1928905511 hasConceptScore W1928905511C94561458 @default.
• W1928905511 hasConceptScore W1928905511C96232424 @default.
• W1928905511 hasConceptScore W1928905511C98274493 @default.
• W1928905511 hasIssue "11" @default.
• W1928905511 hasLocation W19289055111 @default.
• W1928905511 hasOpenAccess W1928905511 @default.
• W1928905511 hasPrimaryLocation W19289055111 @default.
• W1928905511 hasRelatedWork W110051537 @default.
• W1928905511 hasRelatedWork W2081839292 @default.
• W1928905511 hasRelatedWork W2100128089 @default.
• W1928905511 hasRelatedWork W2113612792 @default.
• W1928905511 hasRelatedWork W2187390247 @default.
• W1928905511 hasRelatedWork W2376440477 @default.
• W1928905511 hasRelatedWork W2425544421 @default.
• W1928905511 hasRelatedWork W2792479836 @default.
• W1928905511 hasRelatedWork W2793460677 @default.
• W1928905511 hasRelatedWork W2807902167 @default.
• W1928905511 hasRelatedWork W2901528497 @default.
• W1928905511 hasRelatedWork W2993045939 @default.
• W1928905511 hasRelatedWork W2993468544 @default.
• W1928905511 hasRelatedWork W2999685017 @default.
• W1928905511 hasRelatedWork W3092884302 @default.
• W1928905511 hasRelatedWork W3096756631 @default.
• W1928905511 hasRelatedWork W3203113944 @default.
• W1928905511 hasRelatedWork W1529385150 @default.
• W1928905511 hasRelatedWork W2302841719 @default.
• W1928905511 hasRelatedWork W2471309261 @default.
• W1928905511 hasVolume "7" @default.

• next