FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1928934777> ?p ?o ?g. }

• W1928934777 endingPage "7" @default.
• W1928934777 startingPage "903" @default.
• W1928934777 abstract "The frequent loss of heterozygosity (LOH) demonstrated at chromosome 11p regions in several sporadic malignancies has suggested the presence of tumor suppressor genes at these locations. To obtain detailed mapped incidence of the microsatellite alterations at these regions and to investigate the possible correlation between the genotype and the pathobiological characteristics of head and neck squamous carcinoma, we analyzed paired DNA samples from normal mucosa and primary tumor specimens from 56 patients with these tumors. Our results show that 50.9% of the tumors had microsatellite alterations at one or more of these loci. LOH was manifested in 45. 5% and instability in 5.5% of the tumors. 11p15 loci showed more frequent LOH (39.6%) than those of 11p13 (29.3%) and 11p11-12 (18. 8%); the D11S988 (11p15) marker showed the highest single locus incidence of LOH (29.7%). Eight tumors (22.2%) demonstrated simultaneous LOH at both the 11p15 and 11p13 regions. LOH was significantly associated with poor histological differentiation, DNA aneuploidy, and high proliferative activity in these neoplasms. Our study extends the involvement of the 11p13 and 11p15 regions to head and neck squamous tumorigenesis and indicates that the terminal loci of 11p may harbor a tumor suppressor gene(s) associated with the progression of these tumors." @default.
• W1928934777 created "2016-06-24" @default.
• W1928934777 creator A5000681832 @default.
• W1928934777 creator A5015488796 @default.
• W1928934777 creator A5027863723 @default.
• W1928934777 creator A5077520562 @default.
• W1928934777 creator A5078173230 @default.
• W1928934777 creator A5082254249 @default.
• W1928934777 date "1996-05-01" @default.
• W1928934777 modified "2023-09-23" @default.
• W1928934777 title "Allelic loss and replication errors at microsatellite loci on chromosome 11p in head and neck squamous carcinoma: association with aggressive biological features." @default.
• W1928934777 cites W101106793 @default.
• W1928934777 cites W1502621005 @default.
• W1928934777 cites W1512029533 @default.
• W1928934777 cites W1525223081 @default.
• W1928934777 cites W1582186877 @default.
• W1928934777 cites W1585017542 @default.
• W1928934777 cites W1636306332 @default.
• W1928934777 cites W1780902690 @default.
• W1928934777 cites W194695898 @default.
• W1928934777 cites W1964947899 @default.
• W1928934777 cites W1969439654 @default.
• W1928934777 cites W1979539936 @default.
• W1928934777 cites W1986586530 @default.
• W1928934777 cites W1987460795 @default.
• W1928934777 cites W1998562271 @default.
• W1928934777 cites W2001258296 @default.
• W1928934777 cites W2002484565 @default.
• W1928934777 cites W2012301766 @default.
• W1928934777 cites W2028611809 @default.
• W1928934777 cites W2037749822 @default.
• W1928934777 cites W2041193775 @default.
• W1928934777 cites W2047939698 @default.
• W1928934777 cites W2057967714 @default.
• W1928934777 cites W2058658262 @default.
• W1928934777 cites W2082221644 @default.
• W1928934777 cites W2082889842 @default.
• W1928934777 cites W2091723114 @default.
• W1928934777 cites W2096111973 @default.
• W1928934777 cites W2120899273 @default.
• W1928934777 cites W2142150081 @default.
• W1928934777 cites W2148802890 @default.
• W1928934777 cites W2160997985 @default.
• W1928934777 cites W2739736762 @default.
• W1928934777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9816248" @default.
• W1928934777 hasPublicationYear "1996" @default.
• W1928934777 type Work @default.
• W1928934777 sameAs 1928934777 @default.
• W1928934777 citedByCount "7" @default.
• W1928934777 countsByYear W19289347772012 @default.
• W1928934777 crossrefType "journal-article" @default.
• W1928934777 hasAuthorship W1928934777A5000681832 @default.
• W1928934777 hasAuthorship W1928934777A5015488796 @default.
• W1928934777 hasAuthorship W1928934777A5027863723 @default.
• W1928934777 hasAuthorship W1928934777A5077520562 @default.
• W1928934777 hasAuthorship W1928934777A5078173230 @default.
• W1928934777 hasAuthorship W1928934777A5082254249 @default.
• W1928934777 hasConcept C104317684 @default.
• W1928934777 hasConcept C121608353 @default.
• W1928934777 hasConcept C135763542 @default.
• W1928934777 hasConcept C142724271 @default.
• W1928934777 hasConcept C143589142 @default.
• W1928934777 hasConcept C180754005 @default.
• W1928934777 hasConcept C2776530083 @default.
• W1928934777 hasConcept C2776833033 @default.
• W1928934777 hasConcept C2777546739 @default.
• W1928934777 hasConcept C2778264664 @default.
• W1928934777 hasConcept C2779256057 @default.
• W1928934777 hasConcept C2779672484 @default.
• W1928934777 hasConcept C2779767149 @default.
• W1928934777 hasConcept C2994460389 @default.
• W1928934777 hasConcept C30481170 @default.
• W1928934777 hasConcept C502942594 @default.
• W1928934777 hasConcept C54355233 @default.
• W1928934777 hasConcept C555283112 @default.
• W1928934777 hasConcept C61320498 @default.
• W1928934777 hasConcept C71924100 @default.
• W1928934777 hasConcept C84597430 @default.
• W1928934777 hasConcept C86803240 @default.
• W1928934777 hasConceptScore W1928934777C104317684 @default.
• W1928934777 hasConceptScore W1928934777C121608353 @default.
• W1928934777 hasConceptScore W1928934777C135763542 @default.
• W1928934777 hasConceptScore W1928934777C142724271 @default.
• W1928934777 hasConceptScore W1928934777C143589142 @default.
• W1928934777 hasConceptScore W1928934777C180754005 @default.
• W1928934777 hasConceptScore W1928934777C2776530083 @default.
• W1928934777 hasConceptScore W1928934777C2776833033 @default.
• W1928934777 hasConceptScore W1928934777C2777546739 @default.
• W1928934777 hasConceptScore W1928934777C2778264664 @default.
• W1928934777 hasConceptScore W1928934777C2779256057 @default.
• W1928934777 hasConceptScore W1928934777C2779672484 @default.
• W1928934777 hasConceptScore W1928934777C2779767149 @default.
• W1928934777 hasConceptScore W1928934777C2994460389 @default.
• W1928934777 hasConceptScore W1928934777C30481170 @default.
• W1928934777 hasConceptScore W1928934777C502942594 @default.
• W1928934777 hasConceptScore W1928934777C54355233 @default.
• W1928934777 hasConceptScore W1928934777C555283112 @default.
• W1928934777 hasConceptScore W1928934777C61320498 @default.

• next