FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1929126424> ?p ?o ?g. }

• W1929126424 endingPage "1423" @default.
• W1929126424 startingPage "1415" @default.
• W1929126424 abstract "Abstract Background: The proportion of free prostate-specific antigen (PSA) is higher in the sera of patients with benign prostatic hyperplasia compared with patients with prostate cancer (PCa). We developed an immunoassay that measures intact, free PSA forms (fPSA-I), but does not detect free PSA that has been internally cleaved at Lys145-Lys146 (fPSA-N), and investigated whether this form could discriminate patients with PCa from those without PCa. Methods: The assay for fPSA-I uses a novel monoclonal antibody (MAb) that does not detect PSA that has been internally cleaved at Lys145-Lys146. A MAb specific for free PSA was used as a capture antibody, and purified recombinant proPSA was used as a calibrator. The concentrations of fPSA-I, free PSA (PSA-F), and total PSA (PSA-T) were analyzed in EDTA-plasma samples (n = 276) from patients who participated in a screening program for PCa (PSA-T, 0.83–76.3 μg/L). Results: The detection limit of the fPSA-I assay was 0.035 μg/L. Both the measured concentrations of fPSA-I and the concentrations of fPSA-N (calculated as PSA-F − fPSA-I) provided statistically significant discrimination of the two clinical groups. By contrast, PSA-F did not discriminate between these groups. Each of the ratios fPSA-I/PSA-F, fPSA-N/PSA-T, and PSA-F/PSA-T separated cancer samples from noncancer samples in a statistically significant manner (P &lt;0.0001). The ratio fPSA-I/PSA-F was significantly higher in cancer (median, 59%) compared with noncancer samples (47%). Conclusions: The ratio fPSA-I/PSA-F is significantly higher in cancer compared with noncancer. The percentages of both fPSA-N/PSA-T and fPSA-I/PSA-F may provide interesting diagnostic enhancements alone or in combination with other markers and require further studies." @default.
• W1929126424 created "2016-06-24" @default.
• W1929126424 creator A5022649819 @default.
• W1929126424 creator A5024216962 @default.
• W1929126424 creator A5042371168 @default.
• W1929126424 creator A5056770711 @default.
• W1929126424 creator A5073574939 @default.
• W1929126424 date "2001-08-01" @default.
• W1929126424 modified "2023-10-18" @default.
• W1929126424 title "Discrimination of Prostate Cancer from Benign Disease by Plasma Measurement of Intact, Free Prostate-specific Antigen Lacking an Internal Cleavage Site at Lys145-Lys146" @default.
• W1929126424 cites W1576487122 @default.
• W1929126424 cites W1600339572 @default.
• W1929126424 cites W1845134010 @default.
• W1929126424 cites W1847856759 @default.
• W1929126424 cites W1901056825 @default.
• W1929126424 cites W1984103570 @default.
• W1929126424 cites W1985784441 @default.
• W1929126424 cites W1988872258 @default.
• W1929126424 cites W1997492763 @default.
• W1929126424 cites W2000814246 @default.
• W1929126424 cites W2014980703 @default.
• W1929126424 cites W2019490921 @default.
• W1929126424 cites W2027925208 @default.
• W1929126424 cites W2031383072 @default.
• W1929126424 cites W2042911820 @default.
• W1929126424 cites W2043745504 @default.
• W1929126424 cites W2064180812 @default.
• W1929126424 cites W2068309446 @default.
• W1929126424 cites W2073950466 @default.
• W1929126424 cites W2078354819 @default.
• W1929126424 cites W2081933256 @default.
• W1929126424 cites W2101341907 @default.
• W1929126424 cites W2133756745 @default.
• W1929126424 cites W2166919355 @default.
• W1929126424 cites W2169261424 @default.
• W1929126424 doi "https://doi.org/10.1093/clinchem/47.8.1415" @default.
• W1929126424 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11468231" @default.
• W1929126424 hasPublicationYear "2001" @default.
• W1929126424 type Work @default.
• W1929126424 sameAs 1929126424 @default.
• W1929126424 citedByCount "95" @default.
• W1929126424 countsByYear W19291264242012 @default.
• W1929126424 countsByYear W19291264242013 @default.
• W1929126424 countsByYear W19291264242014 @default.
• W1929126424 countsByYear W19291264242015 @default.
• W1929126424 countsByYear W19291264242016 @default.
• W1929126424 countsByYear W19291264242017 @default.
• W1929126424 countsByYear W19291264242018 @default.
• W1929126424 countsByYear W19291264242019 @default.
• W1929126424 countsByYear W19291264242020 @default.
• W1929126424 countsByYear W19291264242021 @default.
• W1929126424 countsByYear W19291264242022 @default.
• W1929126424 countsByYear W19291264242023 @default.
• W1929126424 crossrefType "journal-article" @default.
• W1929126424 hasAuthorship W1929126424A5022649819 @default.
• W1929126424 hasAuthorship W1929126424A5024216962 @default.
• W1929126424 hasAuthorship W1929126424A5042371168 @default.
• W1929126424 hasAuthorship W1929126424A5056770711 @default.
• W1929126424 hasAuthorship W1929126424A5073574939 @default.
• W1929126424 hasBestOaLocation W19291264242 @default.
• W1929126424 hasConcept C121608353 @default.
• W1929126424 hasConcept C126322002 @default.
• W1929126424 hasConcept C126894567 @default.
• W1929126424 hasConcept C147483822 @default.
• W1929126424 hasConcept C159654299 @default.
• W1929126424 hasConcept C203014093 @default.
• W1929126424 hasConcept C2776235491 @default.
• W1929126424 hasConcept C2777562237 @default.
• W1929126424 hasConcept C2780192828 @default.
• W1929126424 hasConcept C2780420688 @default.
• W1929126424 hasConcept C2781406297 @default.
• W1929126424 hasConcept C29456083 @default.
• W1929126424 hasConcept C3017587882 @default.
• W1929126424 hasConcept C71924100 @default.
• W1929126424 hasConceptScore W1929126424C121608353 @default.
• W1929126424 hasConceptScore W1929126424C126322002 @default.
• W1929126424 hasConceptScore W1929126424C126894567 @default.
• W1929126424 hasConceptScore W1929126424C147483822 @default.
• W1929126424 hasConceptScore W1929126424C159654299 @default.
• W1929126424 hasConceptScore W1929126424C203014093 @default.
• W1929126424 hasConceptScore W1929126424C2776235491 @default.
• W1929126424 hasConceptScore W1929126424C2777562237 @default.
• W1929126424 hasConceptScore W1929126424C2780192828 @default.
• W1929126424 hasConceptScore W1929126424C2780420688 @default.
• W1929126424 hasConceptScore W1929126424C2781406297 @default.
• W1929126424 hasConceptScore W1929126424C29456083 @default.
• W1929126424 hasConceptScore W1929126424C3017587882 @default.
• W1929126424 hasConceptScore W1929126424C71924100 @default.
• W1929126424 hasIssue "8" @default.
• W1929126424 hasLocation W19291264241 @default.
• W1929126424 hasLocation W19291264242 @default.
• W1929126424 hasLocation W19291264243 @default.
• W1929126424 hasOpenAccess W1929126424 @default.
• W1929126424 hasPrimaryLocation W19291264241 @default.
• W1929126424 hasRelatedWork W2023601918 @default.
• W1929126424 hasRelatedWork W2038565121 @default.
• W1929126424 hasRelatedWork W2072590028 @default.
• W1929126424 hasRelatedWork W2390043372 @default.

• next