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- W19291469 abstract "In critically ill humans with manifestation of a systemic inflammatory response syndrome (SIRS), the onset of multi-organ dysfunction syndrome (MODS) is a well known complication that is associated with a high mortality rate. Clinical and experimental evidence increasingly suggests, a disturbance of innate immunity, linked to the uncontrolled activation of the complement system, which results in excessive generation of anaphylatoxins (C3a, C4a, C5a) and impairment of the cellular defense system (especially neutrophil-dysfunction). Such changes may play a central role in the development of MODS. In experimentally-induced MODS, complement depletion, absence of C5 (C5-/- mice), specific blockade of the complement system by C1-inhibitor (C1-INH), soluble complement receptor-1 (sCR-1), blockade of C5a or its C5a receptor (C5aR), all appear to prevent the development of MODS and improve survival. Therefore, irrespective of the initial insult, early inhibition of excessive complement activation during SIRS might be a promising approach for preventing development of the deathly spiral of MODS" @default.
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- W19291469 date "2006-02-17" @default.
- W19291469 modified "2023-09-28" @default.
- W19291469 title "Role of Complement in Multi-Organ Dysfunction Syndrome" @default.
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- W19291469 doi "https://doi.org/10.1007/1-4020-8056-5_22" @default.
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