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- W1929269608 abstract "Antisera to paired helical filaments (PHF) were found to contain a significant amount of tau antibodies specific for a phosphorylated form, but only a negligible amount of those specific for a non-phosphorylated form. Also, the phosphorylated tau-specific antibodies, but not the non-phosphorylated tau-specific ones, labeled neurofibrillary tangles isolated in the presence of sodium dodecyl sulfate (SDS) and stained both tangles and senile plaque neuritis in fixed tissue sections in a very similar way to as the whole antiserum did. Taken together, these results strongly suggest that a major antigenic determinant of PHF is phosphorylated tau itself." @default.
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- W1929269608 date "1986-01-01" @default.
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- W1929269608 title "Phosphorylated Tau Protein Is Integrated into Paired Helical Filaments in Alzheimer's Disease1" @default.
- W1929269608 doi "https://doi.org/10.1093/oxfordjournals.jbchem.a135662" @default.
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