FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1929407592> ?p ?o ?g. }

• W1929407592 endingPage "37" @default.
• W1929407592 startingPage "26" @default.
• W1929407592 abstract "Abstract Genomic analyses have identified segments with high fiber‐forming propensity in many proteins not known to form amyloid. Proteins are often protected from entering the amyloid state by molecular chaperones that permit them to fold in isolation from identical molecules; but, how do proteins self‐chaperone their folding in the absence of chaperones? Here, we explore this question with the stable protein ribonuclease A (RNase A). We previously identified fiber‐forming segments of amyloid‐related proteins and demonstrated that insertion of these segments into the C‐terminal hinge loop of nonfiber‐forming RNase A can convert RNase A into the amyloid state through three‐dimensional domain‐swapping, where the inserted fiber‐forming segments interact to create a steric zipper spine. In this study, we convert RNase A into amyloid‐like fibers by increasing the loop length and hence conformational freedom of an endogenous fiber‐forming segment, SSTSAASS, in the N‐terminal hinge loop. This is accomplished by sandwiching SSTSAASS between inserted Gly residues. With these inserts, SSTSAASS is now able to form the steric zipper spine, allowing RNase A to form amyloid‐like fibers. We show that these fibers contain RNase A molecules retaining their enzymatic activity and therefore native‐like structure. Thus, RNase A appears to prevent fiber formation by limiting the conformational freedom of this fiber‐forming segment from entering a steric zipper. Our observations suggest that proteins have evolved to self‐chaperone by using similar protective mechanisms." @default.
• W1929407592 created "2016-06-24" @default.
• W1929407592 creator A5047546610 @default.
• W1929407592 creator A5053075000 @default.
• W1929407592 creator A5054810341 @default.
• W1929407592 creator A5062412676 @default.
• W1929407592 creator A5080439570 @default.
• W1929407592 creator A5081187128 @default.
• W1929407592 date "2011-11-23" @default.
• W1929407592 modified "2023-10-12" @default.
• W1929407592 title "Ribonuclease A suggests how proteins self-chaperone against amyloid fiber formation" @default.
• W1929407592 cites W1489708565 @default.
• W1929407592 cites W1537264614 @default.
• W1929407592 cites W1591864042 @default.
• W1929407592 cites W1772692214 @default.
• W1929407592 cites W1931712257 @default.
• W1929407592 cites W1964580362 @default.
• W1929407592 cites W1967543592 @default.
• W1929407592 cites W1971087356 @default.
• W1929407592 cites W1973564843 @default.
• W1929407592 cites W1973677589 @default.
• W1929407592 cites W1988352449 @default.
• W1929407592 cites W1989172027 @default.
• W1929407592 cites W1994595152 @default.
• W1929407592 cites W1995017064 @default.
• W1929407592 cites W2002115616 @default.
• W1929407592 cites W2013083986 @default.
• W1929407592 cites W2019261756 @default.
• W1929407592 cites W2027186506 @default.
• W1929407592 cites W2030296989 @default.
• W1929407592 cites W2034589999 @default.
• W1929407592 cites W2036954755 @default.
• W1929407592 cites W2039329450 @default.
• W1929407592 cites W2046033652 @default.
• W1929407592 cites W2049152122 @default.
• W1929407592 cites W2052894184 @default.
• W1929407592 cites W2055501963 @default.
• W1929407592 cites W2058236814 @default.
• W1929407592 cites W2060245311 @default.
• W1929407592 cites W2070539965 @default.
• W1929407592 cites W2070569568 @default.
• W1929407592 cites W2073138345 @default.
• W1929407592 cites W2076834744 @default.
• W1929407592 cites W2081689610 @default.
• W1929407592 cites W2087357689 @default.
• W1929407592 cites W2088776290 @default.
• W1929407592 cites W2090586240 @default.
• W1929407592 cites W2091146715 @default.
• W1929407592 cites W2091480785 @default.
• W1929407592 cites W2098996829 @default.
• W1929407592 cites W2103598875 @default.
• W1929407592 cites W2105216660 @default.
• W1929407592 cites W2110900781 @default.
• W1929407592 cites W2112356204 @default.
• W1929407592 cites W2117537971 @default.
• W1929407592 cites W2121543180 @default.
• W1929407592 cites W2129507901 @default.
• W1929407592 cites W2141104199 @default.
• W1929407592 cites W2146098930 @default.
• W1929407592 cites W2152278845 @default.
• W1929407592 cites W2155537965 @default.
• W1929407592 cites W2162575609 @default.
• W1929407592 cites W2163210644 @default.
• W1929407592 cites W2169579807 @default.
• W1929407592 cites W2408455669 @default.
• W1929407592 doi "https://doi.org/10.1002/pro.754" @default.
• W1929407592 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3323778" @default.
• W1929407592 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22095666" @default.
• W1929407592 hasPublicationYear "2011" @default.
• W1929407592 type Work @default.
• W1929407592 sameAs 1929407592 @default.
• W1929407592 citedByCount "24" @default.
• W1929407592 countsByYear W19294075922012 @default.
• W1929407592 countsByYear W19294075922013 @default.
• W1929407592 countsByYear W19294075922014 @default.
• W1929407592 countsByYear W19294075922015 @default.
• W1929407592 countsByYear W19294075922016 @default.
• W1929407592 countsByYear W19294075922017 @default.
• W1929407592 countsByYear W19294075922019 @default.
• W1929407592 countsByYear W19294075922021 @default.
• W1929407592 countsByYear W19294075922022 @default.
• W1929407592 countsByYear W19294075922023 @default.
• W1929407592 crossrefType "journal-article" @default.
• W1929407592 hasAuthorship W1929407592A5047546610 @default.
• W1929407592 hasAuthorship W1929407592A5053075000 @default.
• W1929407592 hasAuthorship W1929407592A5054810341 @default.
• W1929407592 hasAuthorship W1929407592A5062412676 @default.
• W1929407592 hasAuthorship W1929407592A5080439570 @default.
• W1929407592 hasAuthorship W1929407592A5081187128 @default.
• W1929407592 hasBestOaLocation W19294075922 @default.
• W1929407592 hasConcept C104317684 @default.
• W1929407592 hasConcept C105782903 @default.
• W1929407592 hasConcept C10879258 @default.
• W1929407592 hasConcept C11413529 @default.
• W1929407592 hasConcept C12554922 @default.
• W1929407592 hasConcept C142724271 @default.
• W1929407592 hasConcept C185592680 @default.
• W1929407592 hasConcept C201194858 @default.

• next