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- W1929492703 abstract "Southern blot analysis was used to compare sheep and goat restriction-endonuclease maps of the DNA region containing the alpha-globin genes. The identical digestion patterns observed in both species with three endonucleases (BamHI, BstEII, and PstI) show that in sheep a single chromosome normally bears two nonallelic alpha-globin genes positioned at the same distance as in goat. Variant digestion patterns with enzymes that cleave outside (BamHI and HindIII) and within (EcoRI) the alpha-globin loci allowed us to infer that chromosomes with different numbers of alpha-globin loci are also present in sheep. In particular, in the 60 sheep considered, four individuals were heterozygous (alpha alpha/alpha alpha alpha) and one was homozygous (alpha alpha alpha/alpha alpha alpha) for chromosomes with three loci and one individual was heterozygous for a chromosome with four loci (alpha alpha/alpha alpha alpha alpha). This variation in the number of copies of alpha-globin loci can be explained by means of unequal crossovers." @default.
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- W1929492703 date "1986-03-01" @default.
- W1929492703 modified "2023-10-16" @default.
- W1929492703 title "Variation in the number of alpha-globin loci in sheep." @default.
- W1929492703 doi "https://doi.org/10.1093/oxfordjournals.molbev.a040385" @default.
- W1929492703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2895412" @default.
- W1929492703 hasPublicationYear "1986" @default.
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