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- W1929609820 endingPage "2412" @default.
- W1929609820 startingPage "2400" @default.
- W1929609820 abstract "The immunologically important major histocompatibility complex (MHC) harbors some of the most polymorphic genes in vertebrates. These genes presumably evolve under parasite-mediated selection and frequently show inconsistent allelic genealogies, where some alleles are more similar between species than within species. This phenomenon is thought to arise either from convergent evolution under parallel selection or from the preservation of ancient allelic lineages beyond speciation events (trans-species polymorphism, TSP). Here, we examine natural populations of two sympatric stickleback species (Gasterosteus aculeatus and Pungitius pungitius) to investigate the contribution of these two mechanisms to the evolution of inconsistent allelic genealogies at the MHC. Overlapping parasite taxa between the two host species in three different habitats suggest contemporary parallel selection on the MHC genes. Accordingly, we detected a lack of species-specific phylogenetic clustering in the immunologically relevant antigen-binding residues of the MHC IIB genes which contrasted with the rest of the coding and noncoding sequence. However, clustering was not habitat-specific and a codon-usage analysis revealed patterns of similarity by descent. In this light, common descent via TSP, in combination with intraspecies gene conversion, rather than convergent evolution is the more strongly supported scenario for the inconsistent genealogy at the MHC." @default.
- W1929609820 created "2016-06-24" @default.
- W1929609820 creator A5003870879 @default.
- W1929609820 creator A5005023833 @default.
- W1929609820 creator A5046254274 @default.
- W1929609820 creator A5083547498 @default.
- W1929609820 date "2013-04-30" @default.
- W1929609820 modified "2023-10-16" @default.
- W1929609820 title "EVALUATING PATTERNS OF CONVERGENT EVOLUTION AND TRANS-SPECIES POLYMORPHISM AT MHC IMMUNOGENES IN TWO SYMPATRIC STICKLEBACK SPECIES" @default.
- W1929609820 cites W1506226529 @default.
- W1929609820 cites W1542811994 @default.
- W1929609820 cites W1599660769 @default.
- W1929609820 cites W1652383174 @default.
- W1929609820 cites W1883814365 @default.
- W1929609820 cites W1967749073 @default.
- W1929609820 cites W1972024510 @default.
- W1929609820 cites W1972109913 @default.
- W1929609820 cites W1976989986 @default.
- W1929609820 cites W1984316285 @default.
- W1929609820 cites W1995059907 @default.
- W1929609820 cites W1999203193 @default.
- W1929609820 cites W2003100695 @default.
- W1929609820 cites W2009345785 @default.
- W1929609820 cites W2014569071 @default.
- W1929609820 cites W2014873782 @default.
- W1929609820 cites W2016420601 @default.
- W1929609820 cites W2020384794 @default.
- W1929609820 cites W2023408190 @default.
- W1929609820 cites W2023593777 @default.
- W1929609820 cites W2023657302 @default.
- W1929609820 cites W2023672124 @default.
- W1929609820 cites W2023830740 @default.
- W1929609820 cites W2024088441 @default.
- W1929609820 cites W2028778290 @default.
- W1929609820 cites W2030795858 @default.
- W1929609820 cites W2033339460 @default.
- W1929609820 cites W2034499746 @default.
- W1929609820 cites W2037654474 @default.
- W1929609820 cites W2041626295 @default.
- W1929609820 cites W2042736039 @default.
- W1929609820 cites W2045186898 @default.
- W1929609820 cites W2047400350 @default.
- W1929609820 cites W2050774485 @default.
- W1929609820 cites W2055298722 @default.
- W1929609820 cites W2062131670 @default.
- W1929609820 cites W2064238582 @default.
- W1929609820 cites W2066261119 @default.
- W1929609820 cites W2068379991 @default.
- W1929609820 cites W2068463380 @default.
- W1929609820 cites W2068666365 @default.
- W1929609820 cites W2074417634 @default.
- W1929609820 cites W2078641132 @default.
- W1929609820 cites W2080956086 @default.
- W1929609820 cites W2085674606 @default.
- W1929609820 cites W2086806260 @default.
- W1929609820 cites W2087076382 @default.
- W1929609820 cites W2089485010 @default.
- W1929609820 cites W2093842921 @default.
- W1929609820 cites W2099100192 @default.
- W1929609820 cites W2099422588 @default.
- W1929609820 cites W2100219861 @default.
- W1929609820 cites W2100481775 @default.
- W1929609820 cites W2103546861 @default.
- W1929609820 cites W2108252494 @default.
- W1929609820 cites W2110335151 @default.
- W1929609820 cites W2110835349 @default.
- W1929609820 cites W2112814753 @default.
- W1929609820 cites W2113307627 @default.
- W1929609820 cites W2116428365 @default.
- W1929609820 cites W2116918293 @default.
- W1929609820 cites W2117884309 @default.
- W1929609820 cites W2119900532 @default.
- W1929609820 cites W2120309759 @default.
- W1929609820 cites W2120611093 @default.
- W1929609820 cites W2125063602 @default.
- W1929609820 cites W2129326671 @default.
- W1929609820 cites W2129979981 @default.
- W1929609820 cites W2130783116 @default.
- W1929609820 cites W2132632499 @default.
- W1929609820 cites W2132926880 @default.
- W1929609820 cites W2135308667 @default.
- W1929609820 cites W2141651819 @default.
- W1929609820 cites W2143300715 @default.
- W1929609820 cites W2143612202 @default.
- W1929609820 cites W2150270014 @default.
- W1929609820 cites W2152525478 @default.
- W1929609820 cites W2155994111 @default.
- W1929609820 cites W2157032655 @default.
- W1929609820 cites W2158883833 @default.
- W1929609820 cites W2160721845 @default.
- W1929609820 cites W2163104222 @default.
- W1929609820 cites W2165023167 @default.
- W1929609820 cites W2166651060 @default.
- W1929609820 cites W2167170000 @default.
- W1929609820 cites W2169029547 @default.
- W1929609820 cites W2169337170 @default.
- W1929609820 cites W2170142372 @default.
- W1929609820 cites W2170996473 @default.