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• W1930153672 endingPage "1943" @default.
• W1930153672 startingPage "1935" @default.
• W1930153672 abstract "Abstract Repair of all 12 single-base mismatches in recombination intermediates was investigated in Chinese hamster ovary cells. Extrachromosomal recombination was stimulated by double-strand breaks in regions of shared homology. Recombination was predicted to occur via single-strand annealing, yielding heteroduplex DNA (hDNA) with a single mismatch. Nicks were expected on opposite strands flanking hDNA, equidistant from the mismatch. Unlike studies of covalently closed artificial hDNA substrates, all mismatches were efficiently repaired, consistent with a nick-driven repair process. The average repair efficiency for all mispairs was 92%, with no significant differences among mispairs. There was significant strand-independent repair of G-T → G-C, with a slightly greater bias in a CpG context. Repair of C-A was also biased (toward C-G), but no A-C → G-C bias was found, a possible sequence context effect. No other mismatches showed evidence of biased repair, but among hetero-mismatches, the trend was toward retention of C or G vs. A or T. Repair of both T-T and G-T mismatches was much less efficient in mismatch repair-deficient cells (~25%), and the residual G-T repair was completely biased toward G-C. Our data indicate that single-base mismatches in recombination intermediates are substrates for at least two competing repair systems." @default.
• W1930153672 created "2016-06-24" @default.
• W1930153672 creator A5025591330 @default.
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• W1930153672 creator A5054332041 @default.
• W1930153672 creator A5072160568 @default.
• W1930153672 date "1998-08-01" @default.
• W1930153672 modified "2023-10-06" @default.
• W1930153672 title "Efficient Repair of All Types of Single-Base Mismatches in Recombination Intermediates in Chinese Hamster Ovary Cells: Competition Between Long-Patch and G-T Glycosylase-Mediated Repair of G-T Mismatches" @default.
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• W1930153672 doi "https://doi.org/10.1093/genetics/149.4.1935" @default.
• W1930153672 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1460289" @default.
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