FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1930251011> ?p ?o ?g. }

• W1930251011 abstract "Recruitment and activation of neutrophils at sites of infection/inflammation relies largely on the surface expression of G-protein coupled receptors (GPCRs) that recognize chemoattractants. One of these receptors, FPR1, for which formylated peptides generated by bacteria and mitochondria are high affinity agonists, was among the first human neutrophil GPCR to being cloned. This receptor shares large sequence homologies with FPR2, another member of the FPR-family expressed in human neutrophils and having a distinct ligand binding profile. The two FPRs transduce very similar neutrophil responses but possess somewhat different regulatory profiles. The FPRs have served as excellent model receptors in studies attempting to understand not only GPCR related regulation in general, but also receptor signaling in relation to innate immune reactivity and inflammation. Recent research has identified not only a large number of conventional ligands (agonist/antagonists) that regulate FPR activities by binding to surface exposed parts of the receptors, but also a number of membrane penetrating molecules that allosterically modulate receptor function after passing the membrane and interacting with the receptor on the cytosolic side. After activation, FPR signaling is rapidly terminated and the receptors become desensitized, a dormant state that can be achieved by multiple mechanisms. A coupling of the activated receptors to the actin cytoskeleton in a process that physically separates the receptors from the signaling G-protein is one such mechanism. Traditionally, the desensitized state has been viewed as a point of no return, but recent findings challenge this view and demonstrate that desensitized FPRs may in fact be reactivated to resume active signaling. The FPRs have also the capacity to communicate with other receptors in a hierarchical manner and this receptor cross-talk can both dampen and amplify neutrophil responses. In this review, we summarize some recent advances of our understanding how the FPRs can be turned on and off and discuss some future challenges, including mechanisms of allosteric modulation, receptor cross-talk, and FPR reactivation. Key words: FPRs, neutrophils, GPCRs, cross-talk, desensitization" @default.
• W1930251011 created "2016-06-24" @default.
• W1930251011 date "2014-03-15" @default.
• W1930251011 modified "2023-09-25" @default.
• W1930251011 title "Turning chemoattractant receptors on and off with conventional ligands and allosteric modulators: recent advances in formyl peptide receptor signaling and regulation" @default.
• W1930251011 cites W1487913306 @default.
• W1930251011 cites W1495488363 @default.
• W1930251011 cites W1501628121 @default.
• W1930251011 cites W1531938298 @default.
• W1930251011 cites W1534683796 @default.
• W1930251011 cites W1546558451 @default.
• W1930251011 cites W1547225172 @default.
• W1930251011 cites W1558468202 @default.
• W1930251011 cites W1562436180 @default.
• W1930251011 cites W1575102738 @default.
• W1930251011 cites W1575889916 @default.
• W1930251011 cites W1608128587 @default.
• W1930251011 cites W1631597983 @default.
• W1930251011 cites W1667300941 @default.
• W1930251011 cites W1679944210 @default.
• W1930251011 cites W1724443945 @default.
• W1930251011 cites W1727217767 @default.
• W1930251011 cites W1836708511 @default.
• W1930251011 cites W1965662362 @default.
• W1930251011 cites W1968063902 @default.
• W1930251011 cites W1970426618 @default.
• W1930251011 cites W1976707334 @default.
• W1930251011 cites W1979858376 @default.
• W1930251011 cites W1980166477 @default.
• W1930251011 cites W1982283061 @default.
• W1930251011 cites W1982683163 @default.
• W1930251011 cites W1985018359 @default.
• W1930251011 cites W1990163802 @default.
• W1930251011 cites W1990956893 @default.
• W1930251011 cites W1991580053 @default.
• W1930251011 cites W1993980819 @default.
• W1930251011 cites W1995806055 @default.
• W1930251011 cites W1999974121 @default.
• W1930251011 cites W2000261355 @default.
• W1930251011 cites W2004625863 @default.
• W1930251011 cites W2009187090 @default.
• W1930251011 cites W2010739774 @default.
• W1930251011 cites W2011799827 @default.
• W1930251011 cites W2014813847 @default.
• W1930251011 cites W2018528500 @default.
• W1930251011 cites W2025064241 @default.
• W1930251011 cites W2025266368 @default.
• W1930251011 cites W2025946770 @default.
• W1930251011 cites W2029744871 @default.
• W1930251011 cites W2030691041 @default.
• W1930251011 cites W2038860818 @default.
• W1930251011 cites W2039073030 @default.
• W1930251011 cites W2042881172 @default.
• W1930251011 cites W2045608528 @default.
• W1930251011 cites W2048635536 @default.
• W1930251011 cites W2049662845 @default.
• W1930251011 cites W2050012719 @default.
• W1930251011 cites W2052996144 @default.
• W1930251011 cites W2053202566 @default.
• W1930251011 cites W2053476385 @default.
• W1930251011 cites W2056740603 @default.
• W1930251011 cites W2062050180 @default.
• W1930251011 cites W2064634578 @default.
• W1930251011 cites W2064925178 @default.
• W1930251011 cites W2066068025 @default.
• W1930251011 cites W2066871278 @default.
• W1930251011 cites W2067856993 @default.
• W1930251011 cites W2073860070 @default.
• W1930251011 cites W2077883691 @default.
• W1930251011 cites W2079168625 @default.
• W1930251011 cites W2082024708 @default.
• W1930251011 cites W2082912010 @default.
• W1930251011 cites W2083291253 @default.
• W1930251011 cites W2084988893 @default.
• W1930251011 cites W2087624900 @default.
• W1930251011 cites W2088151763 @default.
• W1930251011 cites W2088452759 @default.
• W1930251011 cites W2091286879 @default.
• W1930251011 cites W2091867054 @default.
• W1930251011 cites W2093201027 @default.
• W1930251011 cites W2096116412 @default.
• W1930251011 cites W2098965240 @default.
• W1930251011 cites W2100607138 @default.
• W1930251011 cites W2101155229 @default.
• W1930251011 cites W2101291779 @default.
• W1930251011 cites W2103010344 @default.
• W1930251011 cites W2106682707 @default.
• W1930251011 cites W2110945179 @default.
• W1930251011 cites W2112545983 @default.
• W1930251011 cites W2112765727 @default.
• W1930251011 cites W2114934533 @default.
• W1930251011 cites W2116516435 @default.
• W1930251011 cites W2120308746 @default.
• W1930251011 cites W2121454777 @default.
• W1930251011 cites W2122842217 @default.
• W1930251011 cites W2127416800 @default.
• W1930251011 cites W2128853794 @default.
• W1930251011 cites W2131896212 @default.
• W1930251011 cites W2132258775 @default.
• W1930251011 cites W2132342511 @default.

• next