FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1930253762> ?p ?o ?g. }

• W1930253762 endingPage "6" @default.
• W1930253762 startingPage "3321" @default.
• W1930253762 abstract "Anti-microtubule drugs and proteasome inhibitors are currently among the most intensively studied anti-tumor agents, however little is known about their pharmacological interactions at the cellular level.The human promyelocytic leukemia cell line, HL-60, was exposed to nocodazole or etoposide in combination with proteasome or caspase inhibitors. Apoptotic cell death was detected by flow cytometry as sub-G1 population. Caspase and proteasome activities were monitored by the fluorogenic substrates Ac-DEVD-AMC and Suc-LLVY-AMC, respectively, in cell lysate. Heat shock protein 70 (HSP70) expression was determined by Western blotting.Nocodazole, a microtubule inhibitor, induced caspase-dependent apoptosis in the HL-60 cell line. At sub-cytotoxic concentrations, proteasome inhibitors, including MG-132 or clasto-beta-lactone, decreased nocodazole-induced apoptotic DNA fragmentation without affecting the induction of caspase-3 activity. In contrast, MG-132 decreased both DNA fragmentation and caspase activation induced by etoposide, a topoisomerase-II inhibitor. HSP70 had previously been found to inhibit apoptosis independently from caspase activation. In this study, MG-132 up-regulated HSP70 protein expression, both in the presence or absence of nocodazole.Proteasome inhibitors decreased anti-microtubule agent-induced apoptotic DNA fragmentation downstream of caspase-3 activation, possibly due to increased HSP70 expression. The results indicate that combination treatment with these novel anti-tumor agents in leukemia requires careful evaluation of their molecular interaction at the level of apoptosis induction." @default.
• W1930253762 created "2016-06-24" @default.
• W1930253762 creator A5007028954 @default.
• W1930253762 creator A5022043593 @default.
• W1930253762 creator A5032001907 @default.
• W1930253762 creator A5040336064 @default.
• W1930253762 creator A5049696281 @default.
• W1930253762 creator A5054331050 @default.
• W1930253762 creator A5057056068 @default.
• W1930253762 creator A5065561626 @default.
• W1930253762 creator A5091224882 @default.
• W1930253762 date "2005-08-17" @default.
• W1930253762 modified "2023-10-12" @default.
• W1930253762 title "Proteasome inhibitors abolish cell death downstream of caspase activation during anti-microtubule drug-induced apoptosis in leukemia cells." @default.
• W1930253762 cites W133083830 @default.
• W1930253762 cites W1537769568 @default.
• W1930253762 cites W1585980551 @default.
• W1930253762 cites W1630927736 @default.
• W1930253762 cites W176186787 @default.
• W1930253762 cites W1970001436 @default.
• W1930253762 cites W1971579914 @default.
• W1930253762 cites W1972071205 @default.
• W1930253762 cites W1972987115 @default.
• W1930253762 cites W1983398917 @default.
• W1930253762 cites W1998391516 @default.
• W1930253762 cites W2016444976 @default.
• W1930253762 cites W2020169963 @default.
• W1930253762 cites W2046639009 @default.
• W1930253762 cites W2051994734 @default.
• W1930253762 cites W2057023866 @default.
• W1930253762 cites W2057514905 @default.
• W1930253762 cites W2057739013 @default.
• W1930253762 cites W2057886903 @default.
• W1930253762 cites W2059882499 @default.
• W1930253762 cites W2064933070 @default.
• W1930253762 cites W2068658690 @default.
• W1930253762 cites W2076390366 @default.
• W1930253762 cites W2077927459 @default.
• W1930253762 cites W2093467508 @default.
• W1930253762 cites W2095324208 @default.
• W1930253762 cites W2101759139 @default.
• W1930253762 cites W2154554320 @default.
• W1930253762 cites W2155850284 @default.
• W1930253762 cites W2167211185 @default.
• W1930253762 cites W2168453180 @default.
• W1930253762 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16101145" @default.
• W1930253762 hasPublicationYear "2005" @default.
• W1930253762 type Work @default.
• W1930253762 sameAs 1930253762 @default.
• W1930253762 citedByCount "1" @default.
• W1930253762 crossrefType "journal-article" @default.
• W1930253762 hasAuthorship W1930253762A5007028954 @default.
• W1930253762 hasAuthorship W1930253762A5022043593 @default.
• W1930253762 hasAuthorship W1930253762A5032001907 @default.
• W1930253762 hasAuthorship W1930253762A5040336064 @default.
• W1930253762 hasAuthorship W1930253762A5049696281 @default.
• W1930253762 hasAuthorship W1930253762A5054331050 @default.
• W1930253762 hasAuthorship W1930253762A5057056068 @default.
• W1930253762 hasAuthorship W1930253762A5065561626 @default.
• W1930253762 hasAuthorship W1930253762A5091224882 @default.
• W1930253762 hasConcept C12519072 @default.
• W1930253762 hasConcept C142669718 @default.
• W1930253762 hasConcept C1491633281 @default.
• W1930253762 hasConcept C153911025 @default.
• W1930253762 hasConcept C185592680 @default.
• W1930253762 hasConcept C18903297 @default.
• W1930253762 hasConcept C190283241 @default.
• W1930253762 hasConcept C191015642 @default.
• W1930253762 hasConcept C27740335 @default.
• W1930253762 hasConcept C2776148510 @default.
• W1930253762 hasConcept C2778367456 @default.
• W1930253762 hasConcept C2779363559 @default.
• W1930253762 hasConcept C31573885 @default.
• W1930253762 hasConcept C43759708 @default.
• W1930253762 hasConcept C55493867 @default.
• W1930253762 hasConcept C86803240 @default.
• W1930253762 hasConcept C95444343 @default.
• W1930253762 hasConcept C98424977 @default.
• W1930253762 hasConceptScore W1930253762C12519072 @default.
• W1930253762 hasConceptScore W1930253762C142669718 @default.
• W1930253762 hasConceptScore W1930253762C1491633281 @default.
• W1930253762 hasConceptScore W1930253762C153911025 @default.
• W1930253762 hasConceptScore W1930253762C185592680 @default.
• W1930253762 hasConceptScore W1930253762C18903297 @default.
• W1930253762 hasConceptScore W1930253762C190283241 @default.
• W1930253762 hasConceptScore W1930253762C191015642 @default.
• W1930253762 hasConceptScore W1930253762C27740335 @default.
• W1930253762 hasConceptScore W1930253762C2776148510 @default.
• W1930253762 hasConceptScore W1930253762C2778367456 @default.
• W1930253762 hasConceptScore W1930253762C2779363559 @default.
• W1930253762 hasConceptScore W1930253762C31573885 @default.
• W1930253762 hasConceptScore W1930253762C43759708 @default.
• W1930253762 hasConceptScore W1930253762C55493867 @default.
• W1930253762 hasConceptScore W1930253762C86803240 @default.
• W1930253762 hasConceptScore W1930253762C95444343 @default.
• W1930253762 hasConceptScore W1930253762C98424977 @default.
• W1930253762 hasIssue "5" @default.
• W1930253762 hasLocation W19302537621 @default.

• next