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• W1930256916 endingPage "16" @default.
• W1930256916 startingPage "3" @default.
• W1930256916 abstract "Little attention has been paid to the function of lipoproteins as part of a nonspecific immune defense system that binds and inactivates microbes and their toxins effectively by complex formation. Because of high extra-capillary tissue pressure, aggregates of such complexes may be trapped in vasa vasorum of the major arteries. This complex formation and aggregation may be enhanced by hyperhomocysteinemia, because homocysteine thiolactone reacts with the free amino groups of apo-B to form homocysteinylated low-density lipoprotein (LDL), which is subject to spontaneous precipitation in vitro. Obstruction of the circulation in vasa vasorum, caused by the aggregated complexes, may result in local ischemia in the arterial wall, intramural cell death, bursting of the capillary, and escape of microorganisms into the intima, all of which lead to inflammation and creation of vulnerable plaques. The presence of homocysteinylated LDL and oxidized LDL stimulates production of LDL autoantibodies, which may start a vicious circle by increasing the complex formation and aggregation of lipoproteins. The content of necrotic debris and leukocytes and the higher temperature than its surroundings give the vulnerable plaque some characteristics of a micro-abscess that by rupturing may initiate an occluding thrombosis. This suggested chain of events explains why many of the clinical symptoms and laboratory findings in acute myocardial infarction are similar to those seen in infectious diseases. It explains the presence of microorganisms in atherosclerotic plaques and why bacteriemia and sepsis are often seen in myocardial infarction complicated with cardiogenic shock. It explains the many associations between infections and cardiovascular disease. And it explains why cholesterol accumulates in the arterial wall. Some risk factors may not cause vascular disease directly, but they may impair the immune system, promote microbial growth, or cause hyperhomocysteinemia, leading to vulnerable plaques." @default.
• W1930256916 created "2016-06-24" @default.
• W1930256916 creator A5014907456 @default.
• W1930256916 creator A5086210261 @default.
• W1930256916 date "2009-01-01" @default.
• W1930256916 modified "2023-09-23" @default.
• W1930256916 title "Review and Hypothesis: Vulnerable plaque formation from obstruction of Vasa vasorum by homocysteinylated and oxidized lipoprotein aggregates complexed with microbial remnants and LDL autoantibodies." @default.
• W1930256916 cites W112146863 @default.
• W1930256916 cites W1524523496 @default.
• W1930256916 cites W1537337979 @default.
• W1930256916 cites W1594429335 @default.
• W1930256916 cites W1737796001 @default.
• W1930256916 cites W1824112222 @default.
• W1930256916 cites W1878095780 @default.
• W1930256916 cites W187903357 @default.
• W1930256916 cites W189348715 @default.
• W1930256916 cites W1902522373 @default.
• W1930256916 cites W1944260161 @default.
• W1930256916 cites W1962256460 @default.
• W1930256916 cites W1966033005 @default.
• W1930256916 cites W1966199777 @default.
• W1930256916 cites W1968382122 @default.
• W1930256916 cites W1968992062 @default.
• W1930256916 cites W1969417111 @default.
• W1930256916 cites W1970844743 @default.
• W1930256916 cites W1974247571 @default.
• W1930256916 cites W1975149587 @default.
• W1930256916 cites W1975571684 @default.
• W1930256916 cites W1977621899 @default.
• W1930256916 cites W1978117628 @default.
• W1930256916 cites W1979466089 @default.
• W1930256916 cites W1979727015 @default.
• W1930256916 cites W1991489628 @default.
• W1930256916 cites W1998234231 @default.
• W1930256916 cites W1998964005 @default.
• W1930256916 cites W1999297034 @default.
• W1930256916 cites W2000111650 @default.
• W1930256916 cites W2000328044 @default.
• W1930256916 cites W2005052069 @default.
• W1930256916 cites W2005797047 @default.
• W1930256916 cites W2012825034 @default.
• W1930256916 cites W2014534729 @default.
• W1930256916 cites W2015690313 @default.
• W1930256916 cites W2018005256 @default.
• W1930256916 cites W2023117694 @default.
• W1930256916 cites W2024803868 @default.
• W1930256916 cites W2027685709 @default.
• W1930256916 cites W2028165627 @default.
• W1930256916 cites W2029650220 @default.
• W1930256916 cites W2035720710 @default.
• W1930256916 cites W2038829792 @default.
• W1930256916 cites W2041264097 @default.
• W1930256916 cites W2041542404 @default.
• W1930256916 cites W2042167738 @default.
• W1930256916 cites W2042574232 @default.
• W1930256916 cites W2043035737 @default.
• W1930256916 cites W2050874860 @default.
• W1930256916 cites W2050919568 @default.
• W1930256916 cites W2052037496 @default.
• W1930256916 cites W2059384713 @default.
• W1930256916 cites W2065733318 @default.
• W1930256916 cites W2067621583 @default.
• W1930256916 cites W2069961866 @default.
• W1930256916 cites W2075896240 @default.
• W1930256916 cites W2080407032 @default.
• W1930256916 cites W2084665604 @default.
• W1930256916 cites W2086654920 @default.
• W1930256916 cites W2086757357 @default.
• W1930256916 cites W2087299185 @default.
• W1930256916 cites W2088444754 @default.
• W1930256916 cites W2089241303 @default.
• W1930256916 cites W2091693528 @default.
• W1930256916 cites W2094941678 @default.
• W1930256916 cites W2095452104 @default.
• W1930256916 cites W2096645345 @default.
• W1930256916 cites W2096730084 @default.
• W1930256916 cites W2096983473 @default.
• W1930256916 cites W2097576373 @default.
• W1930256916 cites W2097789366 @default.
• W1930256916 cites W2099187944 @default.
• W1930256916 cites W2110789882 @default.
• W1930256916 cites W2111787028 @default.
• W1930256916 cites W2112610603 @default.
• W1930256916 cites W2118581125 @default.
• W1930256916 cites W2122823225 @default.
• W1930256916 cites W2123704730 @default.
• W1930256916 cites W2124112912 @default.
• W1930256916 cites W2124927788 @default.
• W1930256916 cites W2127178369 @default.
• W1930256916 cites W2131392583 @default.
• W1930256916 cites W2134738076 @default.
• W1930256916 cites W2135672068 @default.
• W1930256916 cites W2137363193 @default.
• W1930256916 cites W2138158271 @default.
• W1930256916 cites W2141216632 @default.
• W1930256916 cites W2141259094 @default.
• W1930256916 cites W2144571843 @default.
• W1930256916 cites W2144873061 @default.

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