Matches in SemOpenAlex for { <https://semopenalex.org/work/W1930392254> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W1930392254 endingPage "606" @default.
- W1930392254 startingPage "602" @default.
- W1930392254 abstract "To develop a peptide-based radiopharmaceutical for the therapy of αvβ3 receptors overexpressed tumors, we have prepared a novel Arg-Gly-Asp (RGD) peptide (HCRGDCF(D)CRGDC, P12) radiolabeled with 188Re. With His acid at the end of the peptide containing RGD, the label efficiency was more than 95% within 30 min. The peptide binds to human glioblastoma U87MG cells with high affinity [IC50 = 86.3 nm]. The stability of 188Re-P12 in vitro was also investigated. More than 80% of radioactivity was kept in the peptide after 4 h incubation in phosphate buffer solution (pH = 7.4) or calf serum under physiological conditions. Biodistribution of this radiocompound was carried out in mice bearing S180 tumor. Fast clearance of 188Re-peptide from blood and specific uptakes by tumors realized higher tumor-to-blood ratio (1.80) 4 h post-injection. Obvious difference was observed between the blocking and unblocking experiments in whole body autoradiography imaging. These results have demonstrated the potential of 188Re-labeling RGD as a radiotherapeutic agent." @default.
- W1930392254 created "2016-06-24" @default.
- W1930392254 creator A5010107132 @default.
- W1930392254 creator A5013054661 @default.
- W1930392254 creator A5027810506 @default.
- W1930392254 creator A5056416945 @default.
- W1930392254 creator A5061899878 @default.
- W1930392254 creator A5071396730 @default.
- W1930392254 creator A5072370779 @default.
- W1930392254 creator A5083065930 @default.
- W1930392254 date "2011-07-01" @default.
- W1930392254 modified "2023-09-27" @default.
- W1930392254 title "Evaluation of a 188Re-radiolabeled Arg-Gly-Asp peptide for tumor overexpressed αvβ3 receptors" @default.
- W1930392254 cites W135651168 @default.
- W1930392254 cites W143263963 @default.
- W1930392254 cites W1548557309 @default.
- W1930392254 cites W1573363574 @default.
- W1930392254 cites W1667478348 @default.
- W1930392254 cites W1970773634 @default.
- W1930392254 cites W1995855261 @default.
- W1930392254 cites W2001753204 @default.
- W1930392254 cites W2008769552 @default.
- W1930392254 cites W2014642781 @default.
- W1930392254 cites W2018558536 @default.
- W1930392254 cites W2022814481 @default.
- W1930392254 cites W2054728198 @default.
- W1930392254 cites W2065606173 @default.
- W1930392254 cites W2070992269 @default.
- W1930392254 cites W2072735795 @default.
- W1930392254 cites W2094240872 @default.
- W1930392254 cites W2113267611 @default.
- W1930392254 cites W2114286636 @default.
- W1930392254 cites W2137022580 @default.
- W1930392254 cites W2595290893 @default.
- W1930392254 cites W4250428608 @default.
- W1930392254 doi "https://doi.org/10.1002/jlcr.1897" @default.
- W1930392254 hasPublicationYear "2011" @default.
- W1930392254 type Work @default.
- W1930392254 sameAs 1930392254 @default.
- W1930392254 citedByCount "1" @default.
- W1930392254 countsByYear W19303922542012 @default.
- W1930392254 crossrefType "journal-article" @default.
- W1930392254 hasAuthorship W1930392254A5010107132 @default.
- W1930392254 hasAuthorship W1930392254A5013054661 @default.
- W1930392254 hasAuthorship W1930392254A5027810506 @default.
- W1930392254 hasAuthorship W1930392254A5056416945 @default.
- W1930392254 hasAuthorship W1930392254A5061899878 @default.
- W1930392254 hasAuthorship W1930392254A5071396730 @default.
- W1930392254 hasAuthorship W1930392254A5072370779 @default.
- W1930392254 hasAuthorship W1930392254A5083065930 @default.
- W1930392254 hasConcept C170493617 @default.
- W1930392254 hasConcept C185592680 @default.
- W1930392254 hasConcept C202751555 @default.
- W1930392254 hasConcept C2777752497 @default.
- W1930392254 hasConcept C2777807558 @default.
- W1930392254 hasConcept C2779281246 @default.
- W1930392254 hasConcept C55493867 @default.
- W1930392254 hasConceptScore W1930392254C170493617 @default.
- W1930392254 hasConceptScore W1930392254C185592680 @default.
- W1930392254 hasConceptScore W1930392254C202751555 @default.
- W1930392254 hasConceptScore W1930392254C2777752497 @default.
- W1930392254 hasConceptScore W1930392254C2777807558 @default.
- W1930392254 hasConceptScore W1930392254C2779281246 @default.
- W1930392254 hasConceptScore W1930392254C55493867 @default.
- W1930392254 hasIssue "9" @default.
- W1930392254 hasLocation W19303922541 @default.
- W1930392254 hasOpenAccess W1930392254 @default.
- W1930392254 hasPrimaryLocation W19303922541 @default.
- W1930392254 hasRelatedWork W186934237 @default.
- W1930392254 hasRelatedWork W1930392254 @default.
- W1930392254 hasRelatedWork W2048159221 @default.
- W1930392254 hasRelatedWork W2097240451 @default.
- W1930392254 hasRelatedWork W2109311503 @default.
- W1930392254 hasRelatedWork W2390942677 @default.
- W1930392254 hasRelatedWork W2467234707 @default.
- W1930392254 hasRelatedWork W2469824468 @default.
- W1930392254 hasRelatedWork W2605778555 @default.
- W1930392254 hasRelatedWork W3207404993 @default.
- W1930392254 hasVolume "54" @default.
- W1930392254 isParatext "false" @default.
- W1930392254 isRetracted "false" @default.
- W1930392254 magId "1930392254" @default.
- W1930392254 workType "article" @default.