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• W1930446876 abstract "Abstract Strategy, Management and Health Policy Preclinical Research A series of caffeic acid amides with extended P 1′ groups were synthesized and tested for their inhibitory activities on matrix metalloproteinase ( MMP )‐1, MMP ‐2, and MMP ‐9. Compound 3f showed considerable inhibitory activities against MMP ‐2, MMP ‐9, and best selectivity over MMP ‐1. Preliminary structure–activity relationship analysis and docking studies indicated that caffeic acid amides with electron‐donating groups at p ‐position of amino phenyl group showed better inhibitory activities and selectivity than those with electron‐withdrawing groups. The findings of this study would provide information for the exploitation and utilization of caffeic acid as MMP inhibitor for metastatic tumor treatment." @default.
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• W1930446876 date "2012-09-01" @default.
• W1930446876 modified "2023-10-18" @default.
• W1930446876 title "Design, Synthesis and Biological Evaluation of Caffeic Acid Amides as Selective MMP-2 and MMP-9 Inhibitors" @default.
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• W1930446876 doi "https://doi.org/10.1002/ddr.21038" @default.
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