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• W1930462919 endingPage "623" @default.
• W1930462919 startingPage "619" @default.
• W1930462919 abstract "Single (13)C(6)-labeled doses of pteroylmonoglutamic acid (PteGlu: 634 nmol; n = 14), (6S-)5-formyltetrahydrofolic acid (431-569 nmol; n = 16), or [(15)N(1-7)]-intrinsically labeled spinach (mainly 5-methyltetrahydrofolate) (588 nmol; n = 14) were fed to fasting adult volunteers. Plasma-labeled 5-methyltetrahydrofolic acid responses were monitored for 8 h. There was a slower rate of increase in plasma-labeled 5-methyltetrahydrofolic acid and longer time to peak (171 +/- 9 min; mean +/- SEM) following an oral dose of [(13)C(6)]PteGlu than either [(13)C(6)]5-formyltetrahydrofolic acid (54 +/- 10 min) or [(15)N(1-7)]spinach folate (60 +/- 13 min) suggesting saturated metabolic capacity for the biotransformation of PteGlu. Mathematical modeling generated a significantly higher mean apparent absorption for 5-formyltetrahydrofolic acid (38%) and spinach folate (44%) than for PteGlu (24%). The high relative absorption of reduced folates to PteGlu was unexpected given that PteGlu itself, from (14)C-tracer mass balance experiments, is almost completely absorbed. Although it is ubiquitously accepted that a physiological dose of PteGlu is reduced and methylated in the epithelial cells of the small intestine, and that essentially only 5-methyltetrahydrofolic acid is exported into the hepatic portal vein (HPV), as is the case for absorbed reduced 1-carbon-substituted folates, modeling indicated greater liver sequestration when PteGlu was used as the test dose, suggesting that PteGlu enters the HPV unaltered and that the liver is the primary site of initial metabolism. Because of the observed differential plasma response and the hypothesized difference in the site of initial metabolism, the historical use of PteGlu as a reference folate in studies of folate bioavailability is seriously questioned." @default.
• W1930462919 created "2016-06-24" @default.
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• W1930462919 date "2005-03-01" @default.
• W1930462919 modified "2023-10-01" @default.
• W1930462919 title "Differential Kinetic Behavior and Distribution for Pteroylglutamic Acid and Reduced Folates: a Revised Hypothesis of the Primary Site of PteGlu Metabolism in Humans" @default.
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• W1930462919 doi "https://doi.org/10.1093/jn/135.3.619" @default.
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