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• W1930656211 abstract "Abstract CCR5 is a chemokine receptor expressed on leukocytes and a coreceptor used by HIV-1 to enter CD4+ T lymphocytes and macrophages. Stimulation of CCR5 by chemokines triggers internalization of chemokine-bound CCR5 molecules in a process called down-modulation, which contributes to the anti-HIV activity of chemokines. Recent studies have shown that CCR5 conformational heterogeneity influences chemokine-CCR5 interactions and HIV-1 entry in transfected cells or activated CD4+ T lymphocytes. However, the effect of CCR5 conformations on other cell types and on the process of down-modulation remains unclear. We used mAbs, some already shown to detect distinct CCR5 conformations, to compare the behavior of CCR5 on in vitro generated human T cell blasts, monocytes and MDMs and CHO-CCR5 transfectants. All human cells express distinct antigenic forms of CCR5 not detected on CHO-CCR5 cells. The recognizable populations of CCR5 receptors exhibit different patterns of down-modulation on T lymphocytes compared with myeloid cells. On T cell blasts, CCR5 is recognized by all antibodies and undergoes rapid chemokine-mediated internalization, whereas on monocytes and MDMs, a pool of CCR5 molecules is recognized by a subset of antibodies and is not removed from the cell surface. We demonstrate that this cell surface–retained form of CCR5 responds to prolonged treatment with more-potent chemokine analogs and acts as an HIV-1 coreceptor. Our findings indicate that the regulation of CCR5 is highly specific to cell type and provide a potential explanation for the observation that native chemokines are less-effective HIV-entry inhibitors on macrophages compared with T lymphocytes." @default.
• W1930656211 created "2016-06-24" @default.
• W1930656211 creator A5002005480 @default.
• W1930656211 creator A5017947232 @default.
• W1930656211 creator A5019617822 @default.
• W1930656211 creator A5020288455 @default.
• W1930656211 date "2015-05-08" @default.
• W1930656211 modified "2023-09-27" @default.
• W1930656211 title "CCR5 susceptibility to ligand-mediated down-modulation differs between human T lymphocytes and myeloid cells" @default.
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• W1930656211 doi "https://doi.org/10.1189/jlb.2a0414-193rr" @default.
• W1930656211 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4560160" @default.
• W1930656211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25957306" @default.
• W1930656211 hasPublicationYear "2015" @default.
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