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• W1930740023 startingPage "3947" @default.
• W1930740023 abstract "Persistent infection of murine astrocytoma (DBT) cells with mouse hepatitis virus (MHV) has been established. From this in vitro virus-host system, persistence is mediated at the level of cellular MHV receptor (MHVR) expression and increased virus virulence. MHV persistence selects for resistant host cell populations which abate virus replication. Reductions in MHVR expression were significantly associated with increased host resistance, and transfection of MHVR into resistant host cells completely restored the capacity of cells to support efficient replication of MHV strain A59. The emergence of resistant host cells coselected for variant viruses that had increased avidity for MHVR and also recognized different receptors for entry into resistant cells. These data illustrate that MHV persistence in vitro provides a model to identify critical sites of virus-host interaction at the cellular level which are altered during the evolution of host cell resistance to viral infection and the coevolution of virus virulence." @default.
• W1930740023 created "2016-06-24" @default.
• W1930740023 creator A5000944816 @default.
• W1930740023 creator A5059122082 @default.
• W1930740023 date "1996-06-01" @default.
• W1930740023 modified "2023-10-18" @default.
• W1930740023 title "Molecular anatomy of mouse hepatitis virus persistence: coevolution of increased host cell resistance and virus virulence" @default.
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• W1930740023 doi "https://doi.org/10.1128/jvi.70.6.3947-3960.1996" @default.
• W1930740023 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/190273" @default.
• W1930740023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8648732" @default.
• W1930740023 hasPublicationYear "1996" @default.
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