FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1930757563> ?p ?o ?g. }

• W1930757563 endingPage "937" @default.
• W1930757563 startingPage "928" @default.
• W1930757563 abstract "The effects of preoperative versus postoperative fluorouracil (5-FU)-based chemotherapy and irradiation on treatment toxicity, duration of treatment, tumor recurrence, and survival were compared in patients who underwent potentially curative therapy for adenocarcinoma of the pancreatic head during a 5-year period.From July 1990 to July 1995, 142 patients with localized adenocarcinoma of the pancreatic head deemed resectable on the basis of radiographic images were treated with curative intent using a multimodality approach involving either preoperative or postoperative chemoradiation. Patients with biopsy confirmation of adenocarcinoma and a low-density mass in the pancreatic head identified by computed tomography (CT) received preoperative chemoradiation. Patients without a mass on CT or in whom the preoperative biopsy was negative underwent pancreaticoduodenectomy with planned postoperative chemoradiation. Protocol-based preoperative chemoradiation consisted of external-beam irradiation at a dose of 50.4 Gy (standard fractionation; 1.8 Gy/d, 5 d/wk) or 30 Gy (rapid fractionation; 3 Gy/d, 5 d/wk) combined with continuous infusion 5-FU (300 mg/m2/d, 5 d/wk). Postoperative chemoradiation combined 50.4 Gy of external-beam irradiation (standard fractionation) with continuous-infusion 5-FU.No patient who received preoperative chemoradiation experienced a delay in surgery because of chemoradiation toxicity, but six of 25 eligible patients (24%) did not receive postoperative chemoradiation because of delayed recovery after pancreaticoduodenectomy. No significant differences in toxicities from chemoradiation were observed between groups. Patients treated with rapid-fractionation preoperative chemoradiation had a significantly (P < .01) shorter duration of treatment (median, 62.5 days) compared with patients who received postoperative chemoradiation (median, 98.5 days) or standard-fractionation preoperative chemoradiation (median, 91.0 days). At a median followup of 19 months, no significant differences in survival were observed between treatment groups. No patient who received preoperative chemoradiation and pancreaticoduodenectomy experienced a local recurrence; peritoneal (regional) recurrence occurred in 10% of these patients. Local or regional recurrence occurred in 21% of patients who received pancreaticoduodenectomy and postoperative chemoradiation.Delivery of preoperative and postoperative chemoradiation in patients who underwent potentially curative pancreaticoduodenectomy for adenocarcinoma of the pancreatic head resulted in similar treatment toxicity, patterns of tumor recurrence, and survival. Rapid-fractionation preoperative chemoradiation ensured the delivery of all components of therapy to all eligible patients with a significantly shorter duration of treatment than with standard-fractionation chemoradiation given either before or after pancreaticoduodenectomy. Prolonged recovery after pancreaticoduodenectomy prevents the delivery of postoperative adjuvant chemoradiation in up to one fourth of eligible patients." @default.
• W1930757563 created "2016-06-24" @default.
• W1930757563 creator A5006305881 @default.
• W1930757563 creator A5009223258 @default.
• W1930757563 creator A5018129018 @default.
• W1930757563 creator A5021101281 @default.
• W1930757563 creator A5022491856 @default.
• W1930757563 creator A5035766861 @default.
• W1930757563 creator A5076270097 @default.
• W1930757563 creator A5080675098 @default.
• W1930757563 creator A5087376683 @default.
• W1930757563 creator A5088118835 @default.
• W1930757563 creator A5089839809 @default.
• W1930757563 date "1997-03-01" @default.
• W1930757563 modified "2023-10-17" @default.
• W1930757563 title "Preoperative and postoperative chemoradiation strategies in patients treated with pancreaticoduodenectomy for adenocarcinoma of the pancreas." @default.
• W1930757563 cites W1606503260 @default.
• W1930757563 cites W1965404729 @default.
• W1930757563 cites W1981928698 @default.
• W1930757563 cites W1990226772 @default.
• W1930757563 cites W2000424590 @default.
• W1930757563 cites W2000714114 @default.
• W1930757563 cites W2005660567 @default.
• W1930757563 cites W2011280089 @default.
• W1930757563 cites W2015083350 @default.
• W1930757563 cites W2020137989 @default.
• W1930757563 cites W2036796187 @default.
• W1930757563 cites W2040693082 @default.
• W1930757563 cites W2066097107 @default.
• W1930757563 cites W2073810602 @default.
• W1930757563 cites W2077003423 @default.
• W1930757563 cites W2081623967 @default.
• W1930757563 cites W2083467597 @default.
• W1930757563 cites W2085243437 @default.
• W1930757563 cites W2086039705 @default.
• W1930757563 cites W2087154159 @default.
• W1930757563 cites W2087232987 @default.
• W1930757563 cites W2090152036 @default.
• W1930757563 cites W2093834091 @default.
• W1930757563 cites W2103607678 @default.
• W1930757563 cites W2111736523 @default.
• W1930757563 cites W2123754720 @default.
• W1930757563 cites W2140778023 @default.
• W1930757563 cites W2149152013 @default.
• W1930757563 cites W2150881991 @default.
• W1930757563 cites W2304239525 @default.
• W1930757563 cites W2410581598 @default.
• W1930757563 cites W2437811961 @default.
• W1930757563 cites W2595934221 @default.
• W1930757563 cites W2462907503 @default.
• W1930757563 doi "https://doi.org/10.1200/jco.1997.15.3.928" @default.
• W1930757563 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9060530" @default.
• W1930757563 hasPublicationYear "1997" @default.
• W1930757563 type Work @default.
• W1930757563 sameAs 1930757563 @default.
• W1930757563 citedByCount "510" @default.
• W1930757563 countsByYear W19307575632012 @default.
• W1930757563 countsByYear W19307575632013 @default.
• W1930757563 countsByYear W19307575632014 @default.
• W1930757563 countsByYear W19307575632015 @default.
• W1930757563 countsByYear W19307575632016 @default.
• W1930757563 countsByYear W19307575632017 @default.
• W1930757563 countsByYear W19307575632018 @default.
• W1930757563 countsByYear W19307575632019 @default.
• W1930757563 countsByYear W19307575632020 @default.
• W1930757563 countsByYear W19307575632021 @default.
• W1930757563 countsByYear W19307575632022 @default.
• W1930757563 countsByYear W19307575632023 @default.
• W1930757563 crossrefType "journal-article" @default.
• W1930757563 hasAuthorship W1930757563A5006305881 @default.
• W1930757563 hasAuthorship W1930757563A5009223258 @default.
• W1930757563 hasAuthorship W1930757563A5018129018 @default.
• W1930757563 hasAuthorship W1930757563A5021101281 @default.
• W1930757563 hasAuthorship W1930757563A5022491856 @default.
• W1930757563 hasAuthorship W1930757563A5035766861 @default.
• W1930757563 hasAuthorship W1930757563A5076270097 @default.
• W1930757563 hasAuthorship W1930757563A5080675098 @default.
• W1930757563 hasAuthorship W1930757563A5087376683 @default.
• W1930757563 hasAuthorship W1930757563A5088118835 @default.
• W1930757563 hasAuthorship W1930757563A5089839809 @default.
• W1930757563 hasConcept C121608353 @default.
• W1930757563 hasConcept C126322002 @default.
• W1930757563 hasConcept C126838900 @default.
• W1930757563 hasConcept C141071460 @default.
• W1930757563 hasConcept C155806632 @default.
• W1930757563 hasConcept C2775934546 @default.
• W1930757563 hasConcept C2776694085 @default.
• W1930757563 hasConcept C2778424827 @default.
• W1930757563 hasConcept C2778764654 @default.
• W1930757563 hasConcept C2778975757 @default.
• W1930757563 hasConcept C2781182431 @default.
• W1930757563 hasConcept C509974204 @default.
• W1930757563 hasConcept C71924100 @default.
• W1930757563 hasConceptScore W1930757563C121608353 @default.
• W1930757563 hasConceptScore W1930757563C126322002 @default.
• W1930757563 hasConceptScore W1930757563C126838900 @default.
• W1930757563 hasConceptScore W1930757563C141071460 @default.
• W1930757563 hasConceptScore W1930757563C155806632 @default.

• next