FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1930762285> ?p ?o ?g. }

• W1930762285 endingPage "2178" @default.
• W1930762285 startingPage "2167" @default.
• W1930762285 abstract "Cbl family members have an evolutionarily conserved role in attenuating receptor tyrosine kinase function. Their negative regulatory capacity depends on a Ring finger domain that interacts with ubiquitin conjugating enzymes. Cbl molecules constitute a novel type of E3 or ubiquitin ligase family that is recruited to phosphotyrosine motifs. Ubiquitination of the receptor system is coupled to its downregulation, but it is unclear at which point in the endocytic pathway Cbl molecules come into play. Using low temperature and a dynamin mutant, we find that c-Cbl associates with and ubiquitinates the activated epidermal growth factor (EGF) receptor at the plasma membrane in the absence of endocytosis. With the aid of confocal microscopy and immunogold electron microscopy, we could demonstrate that c-Cbl associates with the EGF receptor at the plasma membrane prior to receptor recruitment into clathrin-coated pits and remains associated throughout the clathrin-mediated endocytic pathway. c-Cbl and the EGF receptor also colocalize in internal vesicles of multivesicular endosomes. Our data are consistent with a role for c-Cbl in clathrin-mediated endocytosis of tyrosine kinase receptors, as well as their intracellular sorting." @default.
• W1930762285 created "2016-06-24" @default.
• W1930762285 creator A5013783474 @default.
• W1930762285 creator A5058054208 @default.
• W1930762285 creator A5063187405 @default.
• W1930762285 creator A5081990233 @default.
• W1930762285 creator A5084635195 @default.
• W1930762285 date "2001-06-01" @default.
• W1930762285 modified "2023-10-09" @default.
• W1930762285 title "c-Cbl ubiquitinates the EGF receptor at the plasma membrane and remains receptor associated throughout the endocytic route" @default.
• W1930762285 cites W1513014113 @default.
• W1930762285 cites W1515622122 @default.
• W1930762285 cites W1529429589 @default.
• W1930762285 cites W1565471250 @default.
• W1930762285 cites W1570686199 @default.
• W1930762285 cites W1574457161 @default.
• W1930762285 cites W1592646667 @default.
• W1930762285 cites W1596079370 @default.
• W1930762285 cites W1624856187 @default.
• W1930762285 cites W170428794 @default.
• W1930762285 cites W1961999388 @default.
• W1930762285 cites W1965247392 @default.
• W1930762285 cites W1967626450 @default.
• W1930762285 cites W1967965496 @default.
• W1930762285 cites W1979153707 @default.
• W1930762285 cites W1979171720 @default.
• W1930762285 cites W1980014856 @default.
• W1930762285 cites W1981096579 @default.
• W1930762285 cites W1990259051 @default.
• W1930762285 cites W1995685525 @default.
• W1930762285 cites W1999281989 @default.
• W1930762285 cites W2002223631 @default.
• W1930762285 cites W2004759810 @default.
• W1930762285 cites W2012430176 @default.
• W1930762285 cites W2021109304 @default.
• W1930762285 cites W2024812887 @default.
• W1930762285 cites W2025150927 @default.
• W1930762285 cites W2027533965 @default.
• W1930762285 cites W2030634945 @default.
• W1930762285 cites W2032329087 @default.
• W1930762285 cites W2032422012 @default.
• W1930762285 cites W2032982226 @default.
• W1930762285 cites W2034597081 @default.
• W1930762285 cites W2039328394 @default.
• W1930762285 cites W2042116027 @default.
• W1930762285 cites W2054165881 @default.
• W1930762285 cites W2058216121 @default.
• W1930762285 cites W2060487343 @default.
• W1930762285 cites W2074056249 @default.
• W1930762285 cites W2077017636 @default.
• W1930762285 cites W2077869706 @default.
• W1930762285 cites W2078369440 @default.
• W1930762285 cites W2081500927 @default.
• W1930762285 cites W2082543204 @default.
• W1930762285 cites W2088013881 @default.
• W1930762285 cites W2089593257 @default.
• W1930762285 cites W2092307134 @default.
• W1930762285 cites W2094703210 @default.
• W1930762285 cites W2094866737 @default.
• W1930762285 cites W2095467264 @default.
• W1930762285 cites W2099335992 @default.
• W1930762285 cites W2115569175 @default.
• W1930762285 cites W2116023341 @default.
• W1930762285 cites W2117185170 @default.
• W1930762285 cites W2125919362 @default.
• W1930762285 cites W2127442452 @default.
• W1930762285 cites W2133796471 @default.
• W1930762285 cites W2133809169 @default.
• W1930762285 cites W2153991959 @default.
• W1930762285 cites W2158177598 @default.
• W1930762285 cites W2160410534 @default.
• W1930762285 cites W2161885898 @default.
• W1930762285 cites W2165534710 @default.
• W1930762285 cites W2168379132 @default.
• W1930762285 cites W2169290377 @default.
• W1930762285 cites W2171164575 @default.
• W1930762285 cites W2314870467 @default.
• W1930762285 cites W2353370741 @default.
• W1930762285 cites W4249954471 @default.
• W1930762285 cites W93114066 @default.
• W1930762285 doi "https://doi.org/10.1242/jcs.114.11.2167" @default.
• W1930762285 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11493652" @default.
• W1930762285 hasPublicationYear "2001" @default.
• W1930762285 type Work @default.
• W1930762285 sameAs 1930762285 @default.
• W1930762285 citedByCount "188" @default.
• W1930762285 countsByYear W19307622852012 @default.
• W1930762285 countsByYear W19307622852013 @default.
• W1930762285 countsByYear W19307622852014 @default.
• W1930762285 countsByYear W19307622852015 @default.
• W1930762285 countsByYear W19307622852016 @default.
• W1930762285 countsByYear W19307622852017 @default.
• W1930762285 countsByYear W19307622852018 @default.
• W1930762285 countsByYear W19307622852019 @default.
• W1930762285 countsByYear W19307622852020 @default.
• W1930762285 countsByYear W19307622852021 @default.
• W1930762285 countsByYear W19307622852022 @default.
• W1930762285 countsByYear W19307622852023 @default.

• next