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- W1930883310 endingPage "117" @default.
- W1930883310 startingPage "107" @default.
- W1930883310 abstract "Genomic function is dictated by a combination of DNA sequence and the molecular mechanisms controlling access to genetic information. Access to DNA can be determined by the interpretation of covalent modifications that influence the packaging of DNA into chromatin, including DNA methylation and histone modifications. These modifications are believed to be forms of “epigenetic codes” that exist in discernable combinations that reflect cellular phenotype. Although DNA methylation is known to play important roles in gene regulation and genomic function, its contribution to the encoding of epigenetic information is just beginning to emerge. Here we discuss paradigms associated with the various components of DNA methylation/demethylation and recent advances in the understanding of its dynamic regulation in the genome, integrating these mechanisms into a framework to explain how DNA methylation could contribute to epigenetic codes." @default.
- W1930883310 created "2016-06-24" @default.
- W1930883310 creator A5035262200 @default.
- W1930883310 creator A5039869995 @default.
- W1930883310 date "2013-11-18" @default.
- W1930883310 modified "2023-10-18" @default.
- W1930883310 title "Integrating DNA methylation dynamics into a framework for understanding epigenetic codes" @default.
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