FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1930895061> ?p ?o ?g. }

• W1930895061 endingPage "61" @default.
• W1930895061 startingPage "855" @default.
• W1930895061 abstract "The aim of this study was to do an initial assessment of the usefulness of 2beta-carbomethoxy-3beta-(4-chlorophenyl)-8-(2-(18)F-fluoroethyl)nortropane ((18)F-FECNT) PET scanning in determining in vivo brain dopamine transporter (DAT) density in healthy humans and subjects with Parkinson's disease (PD).We investigated 6 neurologically healthy subjects and 5 PD patients: 2 with mild unilateral disease, 1 with mild-to-moderate bilateral disease, and 2 with moderately severe bilateral disease. The healthy subjects underwent a 3-h PET scan (26 frames) and the PD subjects underwent a 2-h PET scan (23 frames) while (18)F-FECNT was being injected over the first 5 min of the scan. Arterial blood samples were taken throughout scanning for well-counter and metabolite analysis to determine the presence of possible active metabolites. The scans were reconstructed; then we placed spheric regions of interest in the caudate nuclei, putamena, thalami, brain stem, cerebellum, and occipital cortex of each subject. The radioactivity level in each region was calculated for each frame of a subject's PET scan. Then we calculated target tissue-to-cerebellum ratios for each time frame.The analysis of arterial blood samples revealed that metabolism of the tracer was rapid. The ether-extractable component of the arterial input was >98% pure (18)F-FECNT. The caudate nucleus and putamen exhibited the highest uptake and prolonged retention of the radioligand. They both attained maximum uptake at approximately 90 min, with the healthy subjects' average caudate- and putamen-to-cerebellum ratios (+/-SD) at that time being 9.0 +/- 1.2 and 7.8 +/- 0.7, respectively. The maximal caudate-to-cerebellum ratios for the healthy subjects ranged from 7.6 to 10.5 and their maximal putamen-to-cerebellum ratios ranged from 7.1 to 9.3. The 2 early-stage, unilateral PD patients had, at 90 min, an average right caudate-to-cerebellum ratio of 5.3 +/- 1.1 and a left ratio of 5.9 +/- 0.7 and an average right putamen-to cerebellum ratio of 2.8 +/- 0.1 and a left ratio of 3.0 +/- 0.6. The late-stage PD patients had, at 90 min, an average right caudate-to-cerebellum ratio of 3.7 +/- 0.4 and a left ratio of 3.9 +/- 0 and an average right putamen-to cerebellum ratio of 1.8 +/- 0.1 and a left ratio of 1.8 +/- 0.These results indicate that (18)F-FECNT is an excellent candidate radioligand for in vivo imaging of the DAT system in humans. It has a much higher affinity for DAT than for the serotonin transporter and yields the highest peak striatum-to-cerebellum ratios and has among the most favorable kinetics of (18)F-radiolabeled DAT ligands. Having picked up presymptomatic changes in the hemisphere opposite the unaffected side of the body in our early-stage (unilateral) PD patients, it appears that, like other DAT radioligands, it may be able to identify presymptomatic PD." @default.
• W1930895061 created "2016-06-24" @default.
• W1930895061 creator A5029064105 @default.
• W1930895061 creator A5031187490 @default.
• W1930895061 creator A5036023937 @default.
• W1930895061 creator A5047034492 @default.
• W1930895061 creator A5061471861 @default.
• W1930895061 creator A5067317275 @default.
• W1930895061 creator A5079964372 @default.
• W1930895061 creator A5082140726 @default.
• W1930895061 creator A5087980252 @default.
• W1930895061 creator A5090528070 @default.
• W1930895061 date "2003-06-01" @default.
• W1930895061 modified "2023-09-27" @default.
• W1930895061 title "Initial human PET imaging studies with the dopamine transporter ligand 18F-FECNT." @default.
• W1930895061 cites W1562359367 @default.
• W1930895061 cites W1939719114 @default.
• W1930895061 cites W1981781645 @default.
• W1930895061 cites W1987444921 @default.
• W1930895061 cites W1993253047 @default.
• W1930895061 cites W1993316017 @default.
• W1930895061 cites W1997130446 @default.
• W1930895061 cites W2011886282 @default.
• W1930895061 cites W2014331863 @default.
• W1930895061 cites W2020178237 @default.
• W1930895061 cites W2020619932 @default.
• W1930895061 cites W2026861656 @default.
• W1930895061 cites W2047214061 @default.
• W1930895061 cites W2047568835 @default.
• W1930895061 cites W2053093496 @default.
• W1930895061 cites W2055779291 @default.
• W1930895061 cites W2058691511 @default.
• W1930895061 cites W2064996887 @default.
• W1930895061 cites W2070796637 @default.
• W1930895061 cites W2076178634 @default.
• W1930895061 cites W2080313037 @default.
• W1930895061 cites W2090300565 @default.
• W1930895061 cites W2096444106 @default.
• W1930895061 cites W2105369482 @default.
• W1930895061 cites W2107205791 @default.
• W1930895061 cites W2114702980 @default.
• W1930895061 cites W2115045018 @default.
• W1930895061 cites W2131006542 @default.
• W1930895061 cites W2147453648 @default.
• W1930895061 cites W2151128435 @default.
• W1930895061 cites W2161569695 @default.
• W1930895061 cites W2169744965 @default.
• W1930895061 cites W2186027789 @default.
• W1930895061 cites W2402489441 @default.
• W1930895061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12791810" @default.
• W1930895061 hasPublicationYear "2003" @default.
• W1930895061 type Work @default.
• W1930895061 sameAs 1930895061 @default.
• W1930895061 citedByCount "19" @default.
• W1930895061 countsByYear W19308950612012 @default.
• W1930895061 countsByYear W19308950612013 @default.
• W1930895061 countsByYear W19308950612015 @default.
• W1930895061 countsByYear W19308950612017 @default.
• W1930895061 countsByYear W19308950612020 @default.
• W1930895061 countsByYear W19308950612022 @default.
• W1930895061 crossrefType "journal-article" @default.
• W1930895061 hasAuthorship W1930895061A5029064105 @default.
• W1930895061 hasAuthorship W1930895061A5031187490 @default.
• W1930895061 hasAuthorship W1930895061A5036023937 @default.
• W1930895061 hasAuthorship W1930895061A5047034492 @default.
• W1930895061 hasAuthorship W1930895061A5061471861 @default.
• W1930895061 hasAuthorship W1930895061A5067317275 @default.
• W1930895061 hasAuthorship W1930895061A5079964372 @default.
• W1930895061 hasAuthorship W1930895061A5082140726 @default.
• W1930895061 hasAuthorship W1930895061A5087980252 @default.
• W1930895061 hasAuthorship W1930895061A5090528070 @default.
• W1930895061 hasConcept C126322002 @default.
• W1930895061 hasConcept C137183658 @default.
• W1930895061 hasConcept C170493617 @default.
• W1930895061 hasConcept C185592680 @default.
• W1930895061 hasConcept C2776755682 @default.
• W1930895061 hasConcept C2779652256 @default.
• W1930895061 hasConcept C2779714222 @default.
• W1930895061 hasConcept C2780062018 @default.
• W1930895061 hasConcept C2781423529 @default.
• W1930895061 hasConcept C2989005 @default.
• W1930895061 hasConcept C513476851 @default.
• W1930895061 hasConcept C67847695 @default.
• W1930895061 hasConcept C71924100 @default.
• W1930895061 hasConceptScore W1930895061C126322002 @default.
• W1930895061 hasConceptScore W1930895061C137183658 @default.
• W1930895061 hasConceptScore W1930895061C170493617 @default.
• W1930895061 hasConceptScore W1930895061C185592680 @default.
• W1930895061 hasConceptScore W1930895061C2776755682 @default.
• W1930895061 hasConceptScore W1930895061C2779652256 @default.
• W1930895061 hasConceptScore W1930895061C2779714222 @default.
• W1930895061 hasConceptScore W1930895061C2780062018 @default.
• W1930895061 hasConceptScore W1930895061C2781423529 @default.
• W1930895061 hasConceptScore W1930895061C2989005 @default.
• W1930895061 hasConceptScore W1930895061C513476851 @default.
• W1930895061 hasConceptScore W1930895061C67847695 @default.
• W1930895061 hasConceptScore W1930895061C71924100 @default.
• W1930895061 hasIssue "6" @default.

• next