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• W1930943131 abstract "Summary Background Urticaria is the commonest cutaneous reaction caused by aspirin or other nonsteroidal anti-inflammatory drugs. The pathogenesis of aspirin-induced urticaria (AIU) is not fully understood, but appears to involve mast cell activation and neutrophil infiltration. Objectives To investigate the genetic contribution of interleukin (IL)-18, which can amplify acute inflammation by promoting mast cell activation, neutrophil migration and cytokine production, to the pathogenesis of AIU. Methods A case–control association study was performed using 275 patients with AIU and 196 normal healthy controls in a Korean population. Two promoter polymorphisms of the IL18 gene (−607A/C and −137G/C) were genotyped using the primer extension method. The functional effect of the IL18 gene promoter polymorphism was investigated through in vitro studies including a luciferase reporter assay and electrophoretic mobility shift assays (EMSAs) and ex vivo studies involving neutrophil chemotaxis assays. Results A significant association was detected between both AIU in general and the aspirin-intolerant acute urticaria (AIAU) phenotype and the IL18 promoter polymorphism −607A/C. Patients with AIAU showed higher frequencies of the C−607G−137 haplotype, ht1 [CG], compared with controls (P =0·02). Moreover, ht1 [CG] showed a high transcript haplotype by the luciferase activity assay, and EMSAs identified a −607C allele-specific DNA-binding protein as CREB2. Neutrophil chemotactic activity was highest in subjects with AIU exhibiting the high transcript haplotype, ht1 [CG] (P =0·019). Conclusions The high transcript haplotype ht1 [CG] of the IL18 gene may contribute to the development of acute cutaneous inflammation sensitive to aspirin, leading to the clinical presentation of AIAU." @default.
• W1930943131 created "2016-06-24" @default.
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• W1930943131 date "2011-11-01" @default.
• W1930943131 modified "2023-10-16" @default.
• W1930943131 title "A functional promoter polymorphism of the human <i>IL18</i> gene is associated with aspirin-induced urticaria" @default.
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• W1930943131 doi "https://doi.org/10.1111/j.1365-2133.2011.10467.x" @default.
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