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- W1930996948 abstract "Benzyloxyamine derivatives have been shown to be inhibitors of the enzyme dopamine-β-oxidase by virtue of their isosteric relationship to the corresponding phenethylamine derivatives. Benzyloxyamine and two hydroxylated analogues were shown to inhibit the enzyme by a mechanism which is initially competitive with substrate. However, when preincubated with the enzyme the compounds become so firmly bound that substrate cannot readily reverse the inhibition. Although preincubation results in a non-competitive type of inhibition the inhibitor-enzyme complex can, in many instances, be dissociated by prolonged dialysis." @default.
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- W1930996948 date "1963-07-01" @default.
- W1930996948 modified "2023-09-23" @default.
- W1930996948 title "On the mechanism of inhibition of dopamine-beta-oxidase by benzyloxyamines." @default.
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