FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1931054877> ?p ?o ?g. }

• W1931054877 endingPage "1043" @default.
• W1931054877 startingPage "1029" @default.
• W1931054877 abstract "Candida albicans, the major fungal pathogen in humans, undergoes morphological conversion from yeasts to filamentous growth forms depending upon various environmental conditions. Here, we have identified a C. albicans gene, namely SSN6, encoding a putative global transcriptional co-repressor that is highly homologous to the Saccharomyces cerevisiae Ssn6. The isolated C. albicans SSN6 complemented the pleiotropic phenotypes of S. cerevisiae ssn6 mutation, and its expression levels declined significantly in response to a strong true hyphal inducer, serum. The mutant lacking C. albicans Ssn6 displayed a stubby pseudohyphal growth pattern, derepressed filament-specific genes in response to elevated temperature 37 degrees C and failed to develop true hyphae, extensive filamentation and virulence. Such morphological defects of ssn6/ssn6 mutant were not rescued by overexpression of Tup1, Cph1 or Efg1. Moreover, epistatic analysis showed that, as far as cell morphology was concerned, Ssn6 was epistatic to Tup1 at the higher temperature but that, at the lower temperature, the ssn6/ssn6 tup1/tup1 double mutant grew in a stubby form of pseudohyphae distinct from the phenotypes of either single mutant. Furthermore, overexpression of SSN6 in C. albicans led to enhanced filamentous growth and attenuated virulence. These findings suggest that Ssn6 may function as an activator as well as a repressor of filamentous growth and be a target for candidacidal drugs, as its excess or deficiency resulted in impaired virulence." @default.
• W1931054877 created "2016-06-24" @default.
• W1931054877 creator A5043286860 @default.
• W1931054877 creator A5077941210 @default.
• W1931054877 creator A5079477782 @default.
• W1931054877 creator A5080252466 @default.
• W1931054877 creator A5086217569 @default.
• W1931054877 date "2003-02-05" @default.
• W1931054877 modified "2023-09-23" @default.
• W1931054877 title "Ssn6, an important factor of morphological conversion and virulence in Candida albicans" @default.
• W1931054877 cites W1502043817 @default.
• W1931054877 cites W1512267178 @default.
• W1931054877 cites W1565122441 @default.
• W1931054877 cites W1797262463 @default.
• W1931054877 cites W1915890538 @default.
• W1931054877 cites W1917430189 @default.
• W1931054877 cites W1923934287 @default.
• W1931054877 cites W1965771432 @default.
• W1931054877 cites W1970623997 @default.
• W1931054877 cites W1975620486 @default.
• W1931054877 cites W1981078475 @default.
• W1931054877 cites W1982995472 @default.
• W1931054877 cites W1999162249 @default.
• W1931054877 cites W1999340863 @default.
• W1931054877 cites W2003437198 @default.
• W1931054877 cites W2012034776 @default.
• W1931054877 cites W2030202942 @default.
• W1931054877 cites W2037653294 @default.
• W1931054877 cites W2039398422 @default.
• W1931054877 cites W2048093614 @default.
• W1931054877 cites W2049219353 @default.
• W1931054877 cites W2053937029 @default.
• W1931054877 cites W2058216045 @default.
• W1931054877 cites W2059859203 @default.
• W1931054877 cites W2062808396 @default.
• W1931054877 cites W2081954942 @default.
• W1931054877 cites W2085206941 @default.
• W1931054877 cites W2085751002 @default.
• W1931054877 cites W2089819283 @default.
• W1931054877 cites W2091567823 @default.
• W1931054877 cites W2096580557 @default.
• W1931054877 cites W2104218232 @default.
• W1931054877 cites W2104389433 @default.
• W1931054877 cites W2105638437 @default.
• W1931054877 cites W2113880496 @default.
• W1931054877 cites W2115073295 @default.
• W1931054877 cites W2115256513 @default.
• W1931054877 cites W2116147270 @default.
• W1931054877 cites W2117597646 @default.
• W1931054877 cites W2121983416 @default.
• W1931054877 cites W2135705291 @default.
• W1931054877 cites W2135707527 @default.
• W1931054877 cites W2138803099 @default.
• W1931054877 cites W2140935709 @default.
• W1931054877 cites W2145923257 @default.
• W1931054877 cites W2147671956 @default.
• W1931054877 cites W2148698017 @default.
• W1931054877 cites W2159952125 @default.
• W1931054877 cites W2163110564 @default.
• W1931054877 cites W2165011536 @default.
• W1931054877 cites W2169333620 @default.
• W1931054877 cites W2184846376 @default.
• W1931054877 cites W4256400035 @default.
• W1931054877 cites W74095970 @default.
• W1931054877 doi "https://doi.org/10.1046/j.1365-2958.2003.03353.x" @default.
• W1931054877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12581357" @default.
• W1931054877 hasPublicationYear "2003" @default.
• W1931054877 type Work @default.
• W1931054877 sameAs 1931054877 @default.
• W1931054877 citedByCount "64" @default.
• W1931054877 countsByYear W19310548772012 @default.
• W1931054877 countsByYear W19310548772014 @default.
• W1931054877 countsByYear W19310548772015 @default.
• W1931054877 countsByYear W19310548772017 @default.
• W1931054877 countsByYear W19310548772018 @default.
• W1931054877 countsByYear W19310548772019 @default.
• W1931054877 countsByYear W19310548772020 @default.
• W1931054877 countsByYear W19310548772021 @default.
• W1931054877 countsByYear W19310548772022 @default.
• W1931054877 countsByYear W19310548772023 @default.
• W1931054877 crossrefType "journal-article" @default.
• W1931054877 hasAuthorship W1931054877A5043286860 @default.
• W1931054877 hasAuthorship W1931054877A5077941210 @default.
• W1931054877 hasAuthorship W1931054877A5079477782 @default.
• W1931054877 hasAuthorship W1931054877A5080252466 @default.
• W1931054877 hasAuthorship W1931054877A5086217569 @default.
• W1931054877 hasBestOaLocation W19310548771 @default.
• W1931054877 hasConcept C104317684 @default.
• W1931054877 hasConcept C143065580 @default.
• W1931054877 hasConcept C145081991 @default.
• W1931054877 hasConcept C150194340 @default.
• W1931054877 hasConcept C158448853 @default.
• W1931054877 hasConcept C2777576037 @default.
• W1931054877 hasConcept C2780917455 @default.
• W1931054877 hasConcept C54355233 @default.
• W1931054877 hasConcept C60987743 @default.
• W1931054877 hasConcept C86803240 @default.
• W1931054877 hasConcept C89423630 @default.

• next